Epigenetic drugs: from chemistry via biology to medicine and back

por Altucci, Lucia, Rots, Marianne G.
Publicado 2016

Epigenetic Editing: On the Verge of Reprogramming Gene Expression at Will

por Cano-Rodriguez, David, Rots, Marianne G.
Publicado 2016

Exploiting epigenetics for the treatment of inborn errors of metabolism

por Rutten, Martijn G. S., Rots, Marianne G., Oosterveer, Maaike H.
Publicado 2019

The Endothelium as a Target for Anti-Atherogenic Therapy: A Focus on the Epigenetic Enzymes EZH2 and SIRT1

por Fledderus, Jolien, Vanchin, Byambasuren, Rots, Marianne G., Krenning, Guido
Publicado 2021

Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes

por de Groote, Marloes L., Verschure, Pernette J., Rots, Marianne G.
Publicado 2012

Current and upcoming approaches to exploit the reversibility of epigenetic mutations in breast cancer

por Falahi, Fahimeh, van Kruchten, Michel, Martinet, Nadine, Hospers, Geke, Rots, Marianne G
Publicado 2014

The timeline of epigenetic drug discovery: from reality to dreams

por Ganesan, A., Arimondo, Paola B., Rots, Marianne G., Jeronimo, Carmen, Berdasco, María
Publicado 2019

Importance of Metal-Ion Exchange for the Biological Activity of Coordination Complexes of the Biomimetic Ligand N4Py

por Geersing, Arjan, Ségaud, Nathalie, van der Wijst, Monique G. P., Rots, Marianne G., Roelfes, Gerard
Publicado 2018

Gene specific overwriting of epigenetic signatures to modulate the expression of selected tumor-promoting genes in cancer

por Falahi, Fahimeh, Huisman, Christian, Diaz, Elisa Garcia, Kazemier, Hinke G, Hospers, Geke AP, Rots, Marianne G
Publicado 2013

Experimental mitochondria-targeted DNA methylation identifies GpC methylation, not CpG methylation, as potential regulator of mitochondrial gene expression

por van der Wijst, Monique G. P., van Tilburg, Amanda Y., Ruiters, Marcel H. J., Rots, Marianne G.
Publicado 2017

Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer

por Stolzenburg, Sabine, Rots, Marianne G., Beltran, Adriana S., Rivenbark, Ashley G., Yuan, Xinni, Qian, Haili, Strahl, Brian D., Blancafort, Pilar
Publicado 2012

Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter

por Chen, Hui, Kazemier, Hinke G, de Groote, Marloes L., Ruiters, Marcel H. J., Xu, Guo-Liang, Rots, Marianne G.
Publicado 2014

Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

por Cano-Rodriguez, David, Gjaltema, Rutger A F., Jilderda, Laura J, Jellema, Pytrick, Dokter-Fokkens, Jelleke, Ruiters, Marcel H J., Rots, Marianne G
Publicado 2016

Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene

por Ogawara, Ken-ichi, Kułdo, Joanna M, Oosterhuis, Koen, Kroesen, Bart-Jan, Rots, Marianne G, Trautwein, Christian, Kimura, Toshikiro, Haisma, Hidde J, Molema, Grietje
Publicado 2006

Targeted epigenetic silencing of UCHL1 expression suppresses collagen-1 production in human lung epithelial cells

por Wu, Dan-Dan, Lau, Andy T. Y., Xu, Yan-Ming, Reinders-Luinge, Marjan, Koncz, Mihaly, Kiss, Antal, Timens, Wim, Rots, Marianne G., Hylkema, Machteld N.
Publicado 2023

Epigenetic Regulation of S100A9 and S100A12 Expression in Monocyte-Macrophage System in Hyperglycemic Conditions

por Mossel, Dieuwertje M., Moganti, Kondaiah, Riabov, Vladimir, Weiss, Christel, Kopf, Stefan, Cordero, Julio, Dobreva, Gergana, Rots, Marianne G., Klüter, Harald, Harmsen, Martin C., Kzhyshkowska, Julia
Publicado 2020

Targeted DNA Methylation by a DNA Methyltransferase Coupled to a Triple Helix Forming Oligonucleotide To Down-Regulate the Epithelial Cell Adhesion Molecule

por van der Gun, Bernardina T. F., Maluszynska-Hoffman, Maria, Kiss, Antal, Arendzen, Alice J., Ruiters, Marcel H. J., McLaughlin, Pamela M. J., Weinhold, Elmar, Rots, Marianne G.
Publicado 2010

A Role for MeCP2 in Switching Gene Activity via Chromatin Unfolding and HP1γ Displacement

por Brink, Maartje C., Piebes, Diewertje G. E., de Groote, Marloes L., Luijsterburg, Martijn S., Casas-Delucchi, Corella S., van Driel, Roel, Rots, Marianne G., Cardoso, M. Cristina, Verschure, Pernette J.
Publicado 2013

Functional Validation of the Putative Oncogenic Activity of PLAU

por Sarno, Federica, Goubert, Désirée, Logie, Emilie, Rutten, Martijn G. S., Koncz, Mihaly, Deben, Christophe, Niemarkt, Anita E., Altucci, Lucia, Verschure, Pernette J., Kiss, Antal, Berghe, Wim Vanden, Rots, Marianne G.
Publicado 2022

Mitochondrial GpC and CpG DNA Hypermethylation Cause Metabolic Stress-Induced Mitophagy and Cholestophagy

por Theys, Claudia, Ibrahim, Joe, Mateiu, Ligia, Mposhi, Archibold, García-Pupo, Laura, De Pooter, Tim, De Rijk, Peter, Strazisar, Mojca, İnce, İkbal Agah, Vintea, Iuliana, Rots, Marianne G., Vanden Berghe, Wim
Publicado 2023