Synthesis of 2,6-trans-disubstituted 5,6-dihydropyrans from (Z)-1,5-syn-endiols

por Flamme, Eric M, Roush, William R
Publicado 2005

Drug Strategies Targeting CYP51 in Neglected Tropical Diseases

por Choi, Jun Yong, Podust, Larissa M., Roush, William R.
Publicado 2014

Dual-mechanistic antibody-drug conjugate via site-specific selenocysteine/cysteine conjugation

por Nilchan, Napon, Li, Xiuling, Pedzisa, Lee, Nanna, Alex R, Roush, William R, Rader, Christoph
Publicado 2019

Synthesis and Structure–Activity Relationships of Pteridine Dione and Trione Monocarboxylate Transporter 1 Inhibitors

por Wang, Hui, Yang, Chunying, Doherty, Joanne R., Roush, William R., Cleveland, John L., Bannister, Thomas D.
Publicado 2014

In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi

por Chen, Yen Ting, Brinen, Linda S., Kerr, Iain D., Hansell, Elizabeth, Doyle, Patricia S., McKerrow, James H., Roush, William R.
Publicado 2010

Systems analysis of intracellular pH vulnerabilities for cancer therapy

por Persi, Erez, Duran-Frigola, Miquel, Damaghi, Mehdi, Roush, William R., Aloy, Patrick, Cleveland, John L., Gillies, Robert J., Ruppin, Eytan
Publicado 2018

Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth

por Ghalei, Homa, Schaub, Franz X., Doherty, Joanne R., Noguchi, Yoshihiko, Roush, William R., Cleveland, John L., Stroupe, M. Elizabeth, Karbstein, Katrin
Publicado 2015

Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates

por Nanna, Alex R., Li, Xiuling, Walseng, Even, Pedzisa, Lee, Goydel, Rebecca S., Hymel, David, Burke Jr., Terrence R., Roush, William R., Rader, Christoph
Publicado 2017

Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro

por Spicer, Timothy P., Jiang, Jianwen, Taylor, Alexander B., Choi, Jun Yong, Hart, P. John, Roush, William R., Fields, Gregg B., Hodder, Peter S., Minond, Dmitriy
Publicado 2014

Inhibitors of SARS-CoV entry – Identification using an internally-controlled dual envelope pseudovirion assay

por Zhou, Yanchen, Agudelo, Juliet, Lu, Kai, Goetz, David H., Hansell, Elizabeth, Chen, Yen Ting, Roush, William R., McKerrow, James, Craik, Charles S., Amberg, Sean M., Simmons, Graham
Publicado 2011

Molecular Modeling of ABHD5 Structure and Ligand Recognition

por Shahoei, Rezvan, Pangeni, Susheel, Sanders, Matthew A., Zhang, Huamei, Mladenovic-Lucas, Ljiljana, Roush, William R., Halvorsen, Geoff, Kelly, Christopher V., Granneman, James G., Huang, Yu-ming M.
Publicado 2022

Binding Mode and Potency of N-Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51

por Vieira, Debora F., Choi, Jun Yong, Calvet, Claudia M., Siqueira-Neto, Jair Lage, Johnston, Jonathan B., Kellar, Danielle, Gut, Jiri, Cameron, Michael D., McKerrow, James H., Roush, William R., Podust, Larissa M.
Publicado 2014

Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors

por Jílková, Adéla, Rubešová, Petra, Fanfrlík, Jindřich, Fajtová, Pavla, Řezáčová, Pavlína, Brynda, Jiří, Lepšík, Martin, Mertlíková-Kaiserová, Helena, Emal, Cory D., Renslo, Adam R., Roush, William R., Horn, Martin, Caffrey, Conor R., Mareš, Michael
Publicado 2020

4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency

por Calvet, Claudia M., Vieira, Debora F., Choi, Jun Yong, Kellar, Danielle, Cameron, Michael D., Siqueira-Neto, Jair Lage, Gut, Jiri, Johnston, Jonathan B., Lin, Li, Khan, Susan, McKerrow, James H., Roush, William R., Podust, Larissa M.
Publicado 2014

Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase

por McCall, Laura-Isobel, El Aroussi, Amale, Choi, Jun Yong, Vieira, Debora F., De Muylder, Geraldine, Johnston, Jonathan B., Chen, Steven, Kellar, Danielle, Siqueira-Neto, Jair L., Roush, William R., Podust, Larissa M., McKerrow, James H.
Publicado 2015

Suppression of T(H)17 Differentiation and Autoimmunity by a Synthetic ROR Ligand

por Solt, Laura A., Kumar, Naresh, Nuhant, Philippe, Wang, Yongjun, Lauer, Janelle L., Liu, Jin, Istrate, Monica A., Kamenecka, Theodore M., Roush, William R., Vidović, Dušica, Schürer, Stephan C., Xu, Jihong, Wagoner, Gail, Drew, Paul D., Griffin, Patrick R., Burris, Thomas P.
Publicado 2011

The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis

por Torres, Sandra, Brol, Maximilian J, Magdaleno, Fernando, Schierwagen, Robert, Uschner, Frank E., Klein, Sabine, Ortiz, Cristina, Tyc, Olaf, Bachtler, Nadine, Stunden, James, Bertheloot, Damien, Kitanovic, Ana, Sanchez, Brian, Schrum, Jacob, Roush, William R., Franchi, Luigi, Byth, Kate, Latz, Eicke, Trebicka, Jonel
Publicado 2021

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi inf...

por Calvet, Claudia Magalhaes, Choi, Jun Yong, Thomas, Diane, Suzuki, Brian, Hirata, Ken, Lostracco-Johnson, Sharon, de Mesquita, Liliane Batista, Nogueira, Alanderson, Meuser-Batista, Marcelo, Silva, Tatiana Araujo, Siqueira-Neto, Jair Lage, Roush, William R., de Souza Pereira, Mirian Claudia, McKerrow, James H., Podust, Larissa M.
Publicado 2017

CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma

por Burger, Karen L., Fernandez, Mario R., Meads, Mark B., Sudalagunta, Praneeth, Oliveira, Paula S., Renatino Canevarolo, Rafael, Alugubelli, Raghunandan Reddy, Tungsevik, Alexandre, De Avila, Gabe, Silva, Maria, Graeter, Allison I., Dai, Hongyue A., Vincelette, Nicole D., Prabhu, Antony, Magaletti, Dario, Yang, Chunying, Li, Weimin, Kulkarni, Amit, Hampton, Oliver, Koomen, John M., Roush, William R., Monastyrskyi, Andrii, Berglund, Anders E., Silva, Ariosto S., Cleveland, John L., Shain, Kenneth H.
Publicado 2023