A Light-Controlled Allosteric Modulator Unveils a Role for mGlu(4) Receptors During Early Stages of Ischemia in the Rodent Cerebellar Cortex

por Bossi, Simon, Helleringer, Romain, Galante, Micaela, Monlleó, Ester, Trapero, Ana, Rovira, Xavier, Daniel, Hervé, Llebaria, Amadeu, McLean, Heather
Publicado 2018

Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer

por Xue, Li, Sun, Qian, Zhao, Han, Rovira, Xavier, Gai, Siyu, He, Qianwen, Pin, Jean-Philippe, Liu, Jianfeng, Rondard, Philippe
Publicado 2019

Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface

por Liu, Lei, Fan, Zhiran, Rovira, Xavier, Xue, Li, Roux, Salomé, Brabet, Isabelle, Xin, Mingxia, Pin, Jean-Philippe, Rondard, Philippe, Liu, Jianfeng
Publicado 2021

A Photoswitchable Ligand Targeting the β(1)‐Adrenoceptor Enables Light‐Control of the Cardiac Rhythm

por Duran‐Corbera, Anna, Faria, Melissa, Ma, Yuanyuan, Prats, Eva, Dias, André, Catena, Juanlo, Martinez, Karen L., Raldua, Demetrio, Llebaria, Amadeu, Rovira, Xavier
Publicado 2022

Caged-carvedilol as a new tool for visible-light photopharmacology of β-adrenoceptors in native tissues

por Duran-Corbera, Anna, Font, Joan, Faria, Melissa, Prats, Eva, Consegal, Marta, Catena, Juanlo, Muñoz, Lourdes, Raldua, Demetrio, Rodriguez-Sinovas, Antonio, Llebaria, Amadeu, Rovira, Xavier
Publicado 2022

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

por Dalton, James A.R., Lans, Isaias, Rovira, Xavier, Malhaire, Fanny, Gómez-Santacana, Xavier, Pittolo, Silvia, Gorostiza, Pau, Llebaria, Amadeu, Goudet, Cyril, Pin, Jean-Philippe, Giraldo, Jesús
Publicado 2016

Concerted conformational changes control metabotropic glutamate receptor activity

por Lecat-Guillet, Nathalie, Quast, Robert B., Liu, Hongkang, Bourrier, Emmanuel, Møller, Thor C., Rovira, Xavier, Soldevila, Stéphanie, Lamarque, Laurent, Trinquet, Eric, Liu, Jianfeng, Pin, Jean-Philippe, Rondard, Philippe, Margeat, Emmanuel
Publicado 2023

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

por Liu, Junke, Zhang, Zongyong, Moreno-Delgado, David, Dalton, James AR, Rovira, Xavier, Trapero, Ana, Goudet, Cyril, Llebaria, Amadeu, Giraldo, Jesús, Yuan, Qilin, Rondard, Philippe, Huang, Siluo, Liu, Jianfeng, Pin, Jean-Philippe
Publicado 2017

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals

por Gómez-Santacana, Xavier, Pittolo, Silvia, Rovira, Xavier, Lopez, Marc, Zussy, Charleine, Dalton, James A. R., Faucherre, Adèle, Jopling, Chris, Pin, Jean-Philippe, Ciruela, Francisco, Goudet, Cyril, Giraldo, Jesús, Gorostiza, Pau, Llebaria, Amadeu
Publicado 2016

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

por Moreno Delgado, David, Møller, Thor C, Ster, Jeanne, Giraldo, Jesús, Maurel, Damien, Rovira, Xavier, Scholler, Pauline, Zwier, Jurriaan M, Perroy, Julie, Durroux, Thierry, Trinquet, Eric, Prezeau, Laurent, Rondard, Philippe, Pin, Jean-Philippe
Publicado 2017

Optical control of pain in vivo with a photoactive mGlu(5) receptor negative allosteric modulator

por Font, Joan, López-Cano, Marc, Notartomaso, Serena, Scarselli, Pamela, Di Pietro, Paola, Bresolí-Obach, Roger, Battaglia, Giuseppe, Malhaire, Fanny, Rovira, Xavier, Catena, Juanlo, Giraldo, Jesús, Pin, Jean-Philippe, Fernández-Dueñas, Víctor, Goudet, Cyril, Nonell, Santi, Nicoletti, Ferdinando, Llebaria, Amadeu, Ciruela, Francisco
Publicado 2017

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

por Font, Joan, López-Cano, Marc, Notartomaso, Serena, Scarselli, Pamela, Di Prieto, Paola, Bresolí-Obach, Roger, Battaglia, Giuseppe, Malhaire, Fanny, Rovira, Xavier, Catena, Juanlo, Giraldo, Jesús, Pin, Jean-Philippe, Fernández-Dueñas, Víctor, Goudet, Cyril, Nonell, Santi, Nicoletti, Ferdinando, Llebaria, Amadeu, Ciruela, Francisco
Publicado 2018

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

por Scholler, Pauline, Nevoltris, Damien, de Bundel, Dimitri, Bossi, Simon, Moreno-Delgado, David, Rovira, Xavier, Møller, Thor C., El Moustaine, Driss, Mathieu, Michaël, Blanc, Emilie, McLean, Heather, Dupuis, Elodie, Mathis, Gérard, Trinquet, Eric, Daniel, Hervé, Valjent, Emmanuel, Baty, Daniel, Chames, Patrick, Rondard, Philippe, Pin, Jean-Philippe
Publicado 2017