High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor

por Giastas, Petros, Neu, Margarete, Rowland, Paul, Stratikos, Efstratios
Publicado 2019

In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Gro...

por Ross, Leila S., Gamo, Francisco Javier, Lafuente-Monasterio, Maria José, Singh, Onkar M. P., Rowland, Paul, Wiegand, Roger C., Wirth, Dyann F.
Publicado 2014

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

por Hutchinson, Jonathan P., Rowland, Paul, Taylor, Mark R. D., Christodoulou, Erica M., Haslam, Carl, Hobbs, Clare I., Holmes, Duncan S., Homes, Paul, Liddle, John, Mole, Damian J., Uings, Iain, Walker, Ann L., Webster, Scott P., Mowat, Christopher G., Chung, Chun-wa
Publicado 2017

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

por Kokkonda, Sreekanth, El Mazouni, Farah, White, Karen L., White, John, Shackleford, David M., Lafuente-Monasterio, Maria Jose, Rowland, Paul, Manjalanagara, Krishne, Joseph, Jayan T., Garcia-Pérez, Adolfo, Fernandez, Jorge, Gamo, Francisco Javier, Waterson, David, Burrows, Jeremy N., Palmer, Michael J., Charman, Susan A., Rathod, Pradipsinh K., Phillips, Margaret A.
Publicado 2018

Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

por Mole, Damian J, Webster, Scott P, Uings, Iain, Zheng, Xiaozhong, Binnie, Margaret, Wilson, Kris, Hutchinson, Jonathan P, Mirguet, Olivier, Walker, Ann, Beaufils, Benjamin, Ancellin, Nicolas, Trottet, Lionel, Bénéton, Véronique, Mowat, Christopher G, Wilkinson, Martin, Rowland, Paul, Haslam, Carl, McBride, Andrew, Homer, Natalie ZM, Baily, James E, Sharp, Matthew GF, Garden, O James, Hughes, Jeremy, Howie, Sarah EM, Holmes, Duncan S, Liddle, John, Iredale, John P
Publicado 2016

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors

por Thomas, Michael G., McGonagle, Kate, Rowland, Paul, Robinson, David A., Dodd, Peter G., Camino-Díaz, Isabel, Campbell, Lorna, Cantizani, Juan, Castañeda, Pablo, Conn, Daniel, Craggs, Peter D., Edwards, Darren, Ferguson, Liam, Fosberry, Andrew, Frame, Laura, Goswami, Panchali, Hu, Xiao, Korczynska, Justyna, MacLean, Lorna, Martin, Julio, Mutter, Nicole, Osuna-Cabello, Maria, Paterson, Christy, Peña, Imanol, Pinto, Erika G., Pont, Caterina, Riley, Jennifer, Shishikura, Yoko, Simeons, Frederick R. C., Stojanovski, Laste, Thomas, John, Wrobel, Karolina, Young, Robert J., Zmuda, Filip, Zuccotto, Fabio, Read, Kevin D., Gilbert, Ian H., Marco, Maria, Miles, Timothy J., Manzano, Pilar, De Rycker, Manu
Publicado 2023

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

por Wyllie, Susan, Brand, Stephen, Thomas, Michael, De Rycker, Manu, Chung, Chun-wa, Pena, Imanol, Bingham, Ryan P., Bueren-Calabuig, Juan A., Cantizani, Juan, Cebrian, David, Craggs, Peter D., Ferguson, Liam, Goswami, Panchali, Hobrath, Judith, Howe, Jonathan, Jeacock, Laura, Ko, Eun-Jung, Korczynska, Justyna, MacLean, Lorna, Manthri, Sujatha, Martinez, Maria S., Mata-Cantero, Lydia, Moniz, Sonia, Nühs, Andrea, Osuna-Cabello, Maria, Pinto, Erika, Riley, Jennifer, Robinson, Sharon, Rowland, Paul, Simeons, Frederick R. C., Shishikura, Yoko, Spinks, Daniel, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Viayna Gaza, Elisabet, Wall, Richard J., Zuccotto, Fabio, Horn, David, Ferguson, Michael A. J., Fairlamb, Alan H., Fiandor, Jose M., Martin, Julio, Gray, David W., Miles, Timothy J., Gilbert, Ian H., Read, Kevin D., Marco, Maria, Wyatt, Paul G.
Publicado 2019