PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice

por Naumenko, Nikolay, Mutikainen, Maija, Holappa, Lari, Ruas, Jorge L, Tuomainen, Tomi, Tavi, Pasi
Publicado 2021

Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways

por Aesoy, Reidun, Gradin, Katarina, Aasrud, Kathrine S, Hoivik, Erling A, Ruas, Jorge L, Poellinger, Lorenz, Bakke, Marit
Publicado 2014

PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes

por Tuomainen, Tomi, Naumenko, Nikolay, Mutikainen, Maija, Shakirzyanova, Anastasia, Sczelecki, Sarah, Estall, Jennifer L., Ruas, Jorge L., Tavi, Pasi
Publicado 2022

High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles

por Moberg, Marcus, Apró, William, Cervenka, Igor, Ekblom, Björn, van Hall, Gerrit, Holmberg, Hans-Christer, Ruas, Jorge L., Blomstrand, Eva
Publicado 2021

Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias

por Schihada, Hannes, Klompstra, Thomas M., Humphrys, Laura J., Cervenka, Igor, Dadvar, Shamim, Kolb, Peter, Ruas, Jorge L., Schulte, Gunnar
Publicado 2022

Modeling the transport of nuclear proteins along single skeletal muscle cells

por Taylor-Weiner, Hermes, Grigsby, Christopher L., Ferreira, Duarte M. S., Dias, José M., Stevens, Molly M., Ruas, Jorge L., Teixeira, Ana I.
Publicado 2020

Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats

por Kelahmetoglu, Yildiz, Jannig, Paulo R., Cervenka, Igor, Koch, Lauren G., Britton, Steven L., Zhou, Jiajia, Wang, Huating, Robinson, Matthew M., Nair, K Sreekumaran, Ruas, Jorge L.
Publicado 2020

Epiblast-like stem cells established by Wnt/β-catenin signaling manifest distinct features of formative pluripotency and germline competence

por Luo, Qing, Pui, Han-pin, Chen, Jiayu, Yu, Leqian, Jannig, Paulo R., Pei, Yu, Zhao, Linxuan, Chen, Xingqi, Petropoulos, Sophie, Ruas, Jorge L., Wu, Jun, Deng, Qiaolin
Publicado 2023

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

por Ruby, Maxwell A., Massart, Julie, Hunerdosse, Devon M., Schönke, Milena, Correia, Jorge C., Louie, Sharon M., Ruas, Jorge L., Näslund, Erik, Nomura, Daniel K., Zierath, Juleen R.
Publicado 2017

Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk

por Moutinho, Miguel, Nunes, Maria João, Correia, Jorge C., Gama, Maria João, Castro-Caldas, Margarida, Cedazo-Minguez, Angel, Rodrigues, Cecília M. P., Björkhem, Ingemar, Ruas, Jorge L, Rodrigues, Elsa
Publicado 2016

Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans

por Valente-Silva, Paula, Cervenka, Igor, Ferreira, Duarte M. S., Correia, Jorge C., Edman, Sebastian, Horwath, Oscar, Heng, Benjamin, Chow, Sharron, Jacobs, Kelly R., Guillemin, Gilles J., Blomstrand, Eva, Ruas, Jorge L.
Publicado 2021

Obesity-linked phosphorylation of PPARγ by cdk5 is a direct target of the anti-diabetic PPARγ ligands

por Choi, Jang Hyun, Banks, Alexander S., Estall, Jennifer L., Kajimura, Shingo, Bostrom, Pontus, Laznik, Dina, Ruas, Jorge L., Chalmers, Michael J., Kamenecka, Theodore M., Bluher, Matthias, Griffin, Patrick R., Spiegelman, Bruce M.
Publicado 2010

Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

por Agudelo, Leandro Z., Ferreira, Duarte M. S., Dadvar, Shamim, Cervenka, Igor, Ketscher, Lars, Izadi, Manizheh, Zhengye, Liu, Furrer, Regula, Handschin, Christoph, Venckunas, Tomas, Brazaitis, Marius, Kamandulis, Sigitas, Lanner, Johanna T., Ruas, Jorge L.
Publicado 2019

Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

por Massart, Julie, Sjögren, Rasmus J. O., Egan, Brendan, Garde, Christian, Lindgren, Magnus, Gu, Weifeng, Ferreira, Duarte M. S., Katayama, Mutsumi, Ruas, Jorge L., Barrès, Romain, O’Gorman, Donal J., Zierath, Juleen R., Krook, Anna
Publicado 2021

PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments

por Léveillé, Mélissa, Besse-Patin, Aurèle, Jouvet, Nathalie, Gunes, Aysim, Sczelecki, Sarah, Jeromson, Stewart, Khan, Naveen P., Baldwin, Cindy, Dumouchel, Annie, Correia, Jorge C., Jannig, Paulo R., Boulais, Jonathan, Ruas, Jorge L., Estall, Jennifer L.
Publicado 2020

Topologically selective islet vulnerability and self-sustained downregulation of markers for β-cell maturity in streptozotocin-induced diabetes

por Hahn, Max, van Krieken, Pim P., Nord, Christoffer, Alanentalo, Tomas, Morini, Federico, Xiong, Yan, Eriksson, Maria, Mayer, Jürgen, Kostromina, Elena, Ruas, Jorge L., Sharpe, James, Pereira, Teresa, Berggren, Per-Olof, Ilegems, Erwin, Ahlgren, Ulf
Publicado 2020

Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation

por Mills, Richard, Taylor-Weiner, Hermes, Correia, Jorge C., Agudelo, Leandro Z., Allodi, Ilary, Kolonelou, Christina, Martinez-Redondo, Vicente, Ferreira, Duarte M.S., Nichterwitz, Susanne, Comley, Laura H., Lundin, Vanessa, Hedlund, Eva, Ruas, Jorge L., Teixeira, Ana I.
Publicado 2017

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

por Correia, Jorge C., Massart, Julie, de Boer, Jan Freark, Porsmyr-Palmertz, Margareta, Martínez-Redondo, Vicente, Agudelo, Leandro Z., Sinha, Indranil, Meierhofer, David, Ribeiro, Vera, Björnholm, Marie, Sauer, Sascha, Dahlman-Wright, Karin, Zierath, Juleen R., Groen, Albert K., Ruas, Jorge L.
Publicado 2015

Cited4 is a sex‐biased mediator of the antidiabetic glitazone response in adipocyte progenitors

por Bayindir‐Buchhalter, Irem, Wolff, Gretchen, Lerch, Sarah, Sijmonsma, Tjeerd, Schuster, Maximilian, Gronych, Jan, Billeter, Adrian T, Babaei, Rohollah, Krunic, Damir, Ketscher, Lars, Spielmann, Nadine, Hrabe de Angelis, Martin, Ruas, Jorge L, Müller‐Stich, Beat P, Heikenwalder, Mathias, Lichter, Peter, Herzig, Stephan, Vegiopoulos, Alexandros
Publicado 2018

Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration

por Correia, Jorge C., Jannig, Paulo R., Gosztyla, Maya L., Cervenka, Igor, Ducommun, Serge, Præstholm, Stine M., Dumont, Kyle, Liu, Zhengye, Liang, Qishan, Edsgärd, Daniel, Emanuelsson, Olof, Gregorevic, Paul, Westerblad, Håkan, Venckunas, Tomas, Brazaitis, Marius, Kamandulis, Sigitas, Lanner, Johanna T., Yeo, Gene W., Ruas, Jorge L.
Publicado 2023