Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes

por Yu, Hui, Rubinstein, Marcelo, Low, Malcolm J
Publicado 2022

Mouse models for V103I and I251L gain of function variants of the human MC4R display decreased adiposity but are not protected against a hypercaloric diet

por Rojo, Daniela, McCarthy, Clara, Raingo, Jesica, Rubinstein, Marcelo
Publicado 2020

Partial Ablation of Postsynaptic Dopamine D2 Receptors in the Central Nucleus of the Amygdala Increases Risk Avoidance in Exploratory Tasks

por Casey, Eric, Avale, María Elena, Kravitz, Alexxai, Rubinstein, Marcelo
Publicado 2022

Exaptation of Transposable Elements into Novel Cis-Regulatory Elements: Is the Evidence Always Strong?

por de Souza, Flávio S.J., Franchini, Lucía F., Rubinstein, Marcelo
Publicado 2013

MON-709 Single-Cell RNA-Sequencing Deciphers POMC Neuron Destiny

por Yu, Hui, Jones, Graham, Thompson, Zoe, Rubinstein, Marcelo, Low, Malcolm James
Publicado 2020

Positive selection of co-opted mobile genetic elements in a mammalian gene: If you can’t beat them, join them

por Franchini, Lucia F., de Souza, Flavio S.J., Low, Malcolm J., Rubinstein, Marcelo
Publicado 2012

Key role of the dopamine D(4) receptor in the modulation of corticostriatal glutamatergic neurotransmission

por Bonaventura, Jordi, Quiroz, César, Cai, Ning-Sheng, Rubinstein, Marcelo, Tanda, Gianluigi, Ferré, Sergi
Publicado 2017

The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight

por Hael, Clara E., Rojo, Daniela, Orquera, Daniela P., Low, Malcolm J., Rubinstein, Marcelo
Publicado 2020

Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels

por Martyniuk, Kelly M, Torres-Herraez, Arturo, Lowes, Daniel C, Rubinstein, Marcelo, Labouesse, Marie A, Kellendonk, Christoph
Publicado 2022

Ancient Exaptation of a CORE-SINE Retroposon into a Highly Conserved Mammalian Neuronal Enhancer of the Proopiomelanocortin Gene

por Santangelo, Andrea M, de Souza, Flávio S. J, Franchini, Lucía F, Bumaschny, Viviana F, Low, Malcolm J, Rubinstein, Marcelo
Publicado 2007

Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria

por Chhabra, Kavaljit H., Adams, Jessica M., Fagel, Brian, Lam, Daniel D., Qi, Nathan, Rubinstein, Marcelo, Low, Malcolm J.
Publicado 2016

Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice

por Trotta, Milagros, Bello, Estefanía Pilar, Alsina, Ramiro, Tavella, María Belén, Ferrán, José Luis, Rubinstein, Marcelo, Bumaschny, Viviana Florencia
Publicado 2020

Accelerated Evolution Analysis Uncovers PKNOX2 as a Key Transcription Factor in the Mammalian Cochlea

por Trigila, Anabella P, Castagna, Valeria C, Berasain, Lara, Montini, Dante, Rubinstein, Marcelo, Gomez-Casati, Maria Eugenia, Franchini, Lucía F
Publicado 2023

Segregation of brain and organizer precursors is differentially regulated by Nodal signaling at blastula stage

por Castro Colabianchi, Aitana M., Tavella, María B., Boyadjián López, Laura E., Rubinstein, Marcelo, Franchini, Lucía F., López, Silvia L.
Publicado 2021

Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity

por Chhabra, Kavaljit H., Adams, Jessica M., Jones, Graham L., Yamashita, Miho, Schlapschy, Martin, Skerra, Arne, Rubinstein, Marcelo, Low, Malcolm J.
Publicado 2016

Loss of Feedback Inhibition via D2 Autoreceptors Enhances Acquisition of Cocaine Taking and Reactivity to Drug-Paired Cues

por Holroyd, Kathryn B, Adrover, Martin F, Fuino, Robert L, Bock, Roland, Kaplan, Alanna R, Gremel, Christina M, Rubinstein, Marcelo, Alvarez, Veronica A
Publicado 2015

Behavioral and Neuroanatomical Consequences of Cell-Type Specific Loss of Dopamine D2 Receptors in the Mouse Cerebral Cortex

por Lee, Gloria S., Graham, Devon L., Noble, Brenda L., Trammell, Taylor S., McCarthy, Deirdre M., Anderson, Lisa R., Rubinstein, Marcelo, Bhide, Pradeep G., Stanwood, Gregg D.
Publicado 2022

A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors

por Bocarsly, Miriam E., da Silva e Silva, Daniel, Kolb, Vanessa, Luderman, Kathryn D., Shashikiran, Sannidhi, Rubinstein, Marcelo, Sibley, David R., Dobbs, Lauren K., Alvarez, Veronica A.
Publicado 2019

5-HT Obesity Medication Efficacy via POMC Activation is Maintained During Aging

por Burke, Luke K., Doslikova, Barbora, D'Agostino, Giuseppe, Garfield, Alastair S., Farooq, Gala, Burdakov, Denis, Low, Malcolm J., Rubinstein, Marcelo, Evans, Mark L., Billups, Brian, Heisler, Lora K.
Publicado 2014

Striatopallidal neurons control avoidance behavior in exploratory tasks

por LeBlanc, Kimberly H., London, Tanisha D., Szczot, Ilona, Bocarsly, Miriam E., Friend, Danielle M., Nguyen, Katrina P., Mengesha, Marda M., Rubinstein, Marcelo, Alvarez, Veronica A., Kravitz, Alexxai V.
Publicado 2018