Targeting pan-essential pathways in cancer with cytotoxic chemotherapy: challenges and opportunities

por Rudd, Sean G.
Publicado 2023

Targeting the DNA damage response and repair in cancer through nucleotide metabolism

por Helleday, Thomas, Rudd, Sean G.
Publicado 2022

SAMHD1 is a barrier to antimetabolite-based cancer therapies

por Rudd, Sean G., Schaller, Torsten, Herold, Nikolas
Publicado 2017

PrimPol—A new polymerase on the block

por Rudd, Sean G, Bianchi, Julie, Doherty, Aidan J
Publicado 2014

Drug synergy scoring using minimal dose response matrices

por Mäkelä, Petri, Zhang, Si Min, Rudd, Sean G.
Publicado 2021

Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism

por Tsesmetzis, Nikolaos, Paulin, Cynthia B. J., Rudd, Sean G., Herold, Nikolas
Publicado 2018

The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis

por Wang, Jiantao, Hao, Siyuan, Gu, Junjie, Rudd, Sean G., Wang, Yan
Publicado 2022

PPL2 Translesion Polymerase Is Essential for the Completion of Chromosomal DNA Replication in the African Trypanosome

por Rudd, Sean G., Glover, Lucy, Jozwiakowski, Stanislaw K., Horn, David, Doherty, Aidan J.
Publicado 2013

WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line

por Goodfellow, Sarah J., Rebello, Michelle R., Toska, Eneda, Zeef, Leo A. H., Rudd, Sean G., Medler, Kathryn F., Roberts, Stefan G. E.
Publicado 2011

SAMHD1 protects cancer cells from various nucleoside-based antimetabolites

por Herold, Nikolas, Rudd, Sean G., Sanjiv, Kumar, Kutzner, Juliane, Bladh, Julia, Paulin, Cynthia B. J., Helleday, Thomas, Henter, Jan-Inge, Schaller, Torsten
Publicado 2017

PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication

por Bianchi, Julie, Rudd, Sean G., Jozwiakowski, Stanislaw K., Bailey, Laura J., Soura, Violetta, Taylor, Elaine, Stevanovic, Irena, Green, Andrew J., Stracker, Travis H., Lindsay, Howard D., Doherty, Aidan J.
Publicado 2013

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins

por Guilliam, Thomas A., Jozwiakowski, Stanislaw K., Ehlinger, Aaron, Barnes, Ryan P., Rudd, Sean G., Bailey, Laura J., Skehel, J. Mark, Eckert, Kristin A., Chazin, Walter J., Doherty, Aidan J.
Publicado 2015

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

por Ceder, Sophia, Eriksson, Sofi E., Liang, Ying Yu, Cheteh, Emarndeena H., Zhang, Si Min, Fujihara, Kenji M., Bianchi, Julie, Bykov, Vladimir J. N., Abrahmsen, Lars, Clemons, Nicholas J., Nordlund, Pär, Rudd, Sean G., Wiman, Klas G.
Publicado 2021

Correction: Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

por Ceder, Sophia, Eriksson, Sofi E., Liang, Ying Yu, Cheteh, Emarndeena H., Zhang, Si Min, Fujihara, Kenji M., Bianchi, Julie, Bykov, Vladimir J. N., Abrahmsen, Lars, Clemons, Nicholas J., Nordlund, Pär, Rudd, Sean G., Wiman, Klas G.
Publicado 2022

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

por Rehling, Daniel, Zhang, Si Min, Jemth, Ann-Sofie, Koolmeister, Tobias, Throup, Adam, Wallner, Olov, Scaletti, Emma, Moriyama, Takaya, Nishii, Rina, Davies, Jonathan, Desroses, Matthieu, Rudd, Sean G., Scobie, Martin, Homan, Evert, Berglund, Ulrika Warpman, Yang, Jun J., Helleday, Thomas, Stenmark, Pål
Publicado 2021

Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens

por Rassidakis, George Z., Herold, Nikolas, Myrberg, Ida Hed, Tsesmetzis, Nikolaos, Rudd, Sean G., Henter, Jan-Inge, Schaller, Torsten, Ng, Siok-Bian, Chng, Wee Joo, Yan, Benedict, Ng, Chin Hin, Ravandi, Farhad, Andreeff, Michael, Kantarjian, Hagop M., Medeiros, L. Jeffrey, Xagoraris, Ioanna, Khoury, Joseph D.
Publicado 2018

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

por Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Publicado 2018

Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

por Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Publicado 2019

Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy

por Rudd, Sean G, Tsesmetzis, Nikolaos, Sanjiv, Kumar, Paulin, Cynthia BJ, Sandhow, Lakshmi, Kutzner, Juliane, Hed Myrberg, Ida, Bunten, Sarah S, Axelsson, Hanna, Zhang, Si Min, Rasti, Azita, Mäkelä, Petri, Coggins, Si'Ana A, Tao, Sijia, Suman, Sharda, Branca, Rui M, Mermelekas, Georgios, Wiita, Elisée, Lee, Sun, Walfridsson, Julian, Schinazi, Raymond F, Kim, Baek, Lehtiö, Janne, Rassidakis, Georgios Z, Pokrovskaja Tamm, Katja, Warpman‐Berglund, Ulrika, Heyman, Mats, Grandér, Dan, Lehmann, Sören, Lundbäck, Thomas, Qian, Hong, Henter, Jan‐Inge, Schaller, Torsten, Helleday, Thomas, Herold, Nikolas
Publicado 2020

Development of a chemical probe against NUDT15

por Zhang, Si Min, Desroses, Matthieu, Hagenkort, Anna, Valerie, Nicholas C.K., Rehling, Daniel, Carter, Megan, Wallner, Olov, Koolmeister, Tobias, Throup, Adam, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Lundbäck, Thomas, Axelsson, Hanna, Regmi, Shruti, Sarno, Antonio, Krämer, Andreas, Pudelko, Linda, Bräutigam, Lars, Rasti, Azita, Göttmann, Mona, Wiita, Elisée, Kutzner, Juliane, Schaller, Torsten, Kalderén, Christina, Cázares-Körner, Armando, Page, Brent D. G., Krimpenfort, Rosa, Eshtad, Saeed, Altun, Mikael, Rudd, Sean G., Knapp, Stefan, Scobie, Martin, Homan, Evert J., Berglund, Ulrika Warpman, Stenmark, Pål, Helleday, Thomas
Publicado 2020