Biosynthesis, enzymology, and future of eunicellane diterpenoids

por Li, Zining, Rudolf, Jeffrey D
Publicado 2023

Structure-guided product determination of the bacterial type II diterpene synthase Tpn2

por Stowell, Emma A., Ehrenberger, Michelle A., Lin, Ya-Lin, Chang, Chin-Yuan, Rudolf, Jeffrey D.
Publicado 2022

Enediyne Polyketide Synthases Stereoselectively Reduce the β-Ketoacyl Intermediates to β-d-Hydroxyacyl Intermediates in Enediyne Core Biosynthesis

por Ge, Hui-Ming, Huang, Tingting, Rudolf, Jeffrey D., Lohman, Jeremy R., Huang, Sheng-Xiong, Guo, Xun, Shen, Ben
Publicado 2014

Enediynes: Exploration of microbial genomics to discover new anticancer drug leads

por Shen, Ben, Hindra, Yan, Xiaohui, Huang, Tingting, Ge, Huiming, Yang, Dong, Teng, Qihui, Rudolf, Jeffrey D., Lohman, Jeremy R.
Publicado 2014

BlmB and TlmB Provide Resistance to the Bleomycin Family of Antitumor Antibiotics by N-Acetylating Metal-Free Bleomycin, Tallysomycin, Phleomycin, and Zorbamycin

por Coughlin, Jane M., Rudolf, Jeffrey D., Wendt-Pienkowski, Evelyn, Wang, Liyan, Unsin, Claudia, Galm, Ute, Yang, Dong, Tao, Meifeng, Shen, Ben
Publicado 2014

Biosynthesis of thiocarboxylic acid-containing natural products

por Dong, Liao-Bin, Rudolf, Jeffrey D., Kang, Dingding, Wang, Nan, He, Cyndi Qixin, Deng, Youchao, Huang, Yong, Houk, K. N., Duan, Yanwen, Shen, Ben
Publicado 2018

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis

por Annaval, Thibault, Rudolf, Jeffrey D., Chang, Chin-Yuan, Lohman, Jeremy R., Kim, Youngchang, Bigelow, Lance, Jedrzejczak, Robert, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Publicado 2017

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme

por Wang, Nan, Rudolf, Jeffrey D., Dong, Liao-Bin, Osipiuk, Jerzy, Hatzos-Skintges, Catherine, Endres, Michael, Chang, Chin-Yuan, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Publicado 2018

Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase

por Rudolf, Jeffrey D., Dong, Liao-Bin, Cao, Hongnan, Hatzos-Skintges, Catherine, Osipiuk, Jerzy, Endres, Michael, Chang, Chin-Yuan, Ma, Ming, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Publicado 2016

Strain Prioritization for Natural Product Discovery by a High-Throughput Real-Time PCR Method

por Hindra, Huang, Tingting, Yang, Dong, Rudolf, Jeffrey D., Xie, Pengfei, Xie, Guangbo, Teng, Qihui, Lohman, Jeremy R., Zhu, Xiangcheng, Huang, Yong, Zhao, Li-Xing, Jiang, Yi, Duan, Yanwen, Shen, Ben
Publicado 2014

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne A...

por Chang, Chin-Yuan, Lohman, Jeremy R., Cao, Hongnan, Tan, Kemin, Rudolf, Jeffrey D., Ma, Ming, Xu, Weijun, Bingman, Craig A., Yennamalli, Ragothaman M., Bigelow, Lance, Babnigg, Gyorgy, Yan, Xiaohui, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Publicado 2016

Biosynthetic Potential-Based Strain Prioritization for Natural Product Discovery: A Showcase for Diterpenoid-Producing Actinomycetes

por Xie, Pengfei, Ma, Ming, Rateb, Mostafa E., Shaaban, Khaled A., Yu, Zhiguo, Huang, Sheng-Xiong, Zhao, Li-Xing, Zhu, Xiangcheng, Yan, Yijun, Peterson, Ryan M., Lohman, Jeremy R., Yang, Dong, Yin, Min, Rudolf, Jeffrey D., Jiang, Yi, Duan, Yanwen, Shen, Ben
Publicado 2014

Strain Prioritization and Genome Mining for Enediyne Natural Products

por Yan, Xiaohui, Ge, Huiming, Huang, Tingting, Hindra, Yang, Dong, Teng, Qihui, Crnovčić, Ivana, Li, Xiuling, Rudolf, Jeffrey D., Lohman, Jeremy R., Gansemans, Yannick, Zhu, Xiangcheng, Huang, Yong, Zhao, Li-Xing, Jiang, Yi, Van Nieuwerburgh, Filip, Rader, Christoph, Duan, Yanwen, Shen, Ben
Publicado 2016

Crystal Structure of SgcJ, An NTF2-Like Superfamily Protein Involved in Biosynthesis of the 9-Membered Enediyne Antitumor Antibiotic C-1027

por Huang, Tingting, Chang, Chin-Yuan, Lohman, Jeremy R., Rudolf, Jeffrey D., Kim, Youngchang, Chang, Changsoo, Yang, Dong, Ma, Ming, Yan, Xiaohui, Crnovcic, Ivana, Bigelow, Lance, Clancy, Shonda, Bingman, Craig A., Yennamalli, Ragothaman M., Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Publicado 2016

The Natural Products Atlas 2.0: a database of microbially-derived natural products

por van Santen, Jeffrey A, Poynton, Ella F, Iskakova, Dasha, McMann, Emily, Alsup, Tyler A, Clark, Trevor N, Fergusson, Claire H, Fewer, David P, Hughes, Alison H, McCadden, Caitlin A, Parra, Jonathan, Soldatou, Sylvia, Rudolf, Jeffrey D, Janssen, Elisabeth M-L, Duncan, Katherine R, Linington, Roger G
Publicado 2021

A roadmap for the functional annotation of protein families: a community perspective

por de Crécy-lagard, Valérie, Amorin de Hegedus, Rocio, Arighi, Cecilia, Babor, Jill, Bateman, Alex, Blaby, Ian, Blaby-Haas, Crysten, Bridge, Alan J, Burley, Stephen K, Cleveland, Stacey, Colwell, Lucy J, Conesa, Ana, Dallago, Christian, Danchin, Antoine, de Waard, Anita, Deutschbauer, Adam, Dias, Raquel, Ding, Yousong, Fang, Gang, Friedberg, Iddo, Gerlt, John, Goldford, Joshua, Gorelik, Mark, Gyori, Benjamin M, Henry, Christopher, Hutinet, Geoffrey, Jaroch, Marshall, Karp, Peter D, Kondratova, Liudmyla, Lu, Zhiyong, Marchler-Bauer, Aron, Martin, Maria-Jesus, McWhite, Claire, Moghe, Gaurav D, Monaghan, Paul, Morgat, Anne, Mungall, Christopher J, Natale, Darren A, Nelson, William C, O’Donoghue, Seán, Orengo, Christine, O’Toole, Katherine H, Radivojac, Predrag, Reed, Colbie, Roberts, Richard J, Rodionov, Dmitri, Rodionova, Irina A, Rudolf, Jeffrey D, Saleh, Lana, Sheynkman, Gloria, Thibaud-Nissen, Francoise, Thomas, Paul D, Uetz, Peter, Vallenet, David, Carter, Erica Watson, Weigele, Peter R, Wood, Valerie, Wood-Charlson, Elisha M, Xu, Jin
Publicado 2022