An improved statistical method to identify chemical-genetic interactions by exploiting concentration-dependence

por Dutta, Esha, DeJesus, Michael A., Ruecker, Nadine, Zaveri, Anisha, Koh, Eun-Ik, Sassetti, Christopher M., Schnappinger, Dirk, Ioerger, Thomas R.
Publicado 2021

Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis

por Bosch, Barbara, DeJesus, Michael A., Poulton, Nicholas C., Zhang, Wenzhu, Engelhart, Curtis A., Zaveri, Anisha, Lavalette, Sophie, Ruecker, Nadine, Trujillo, Carolina, Wallach, Joshua B., Li, Shuqi, Ehrt, Sabine, Chait, Brian T., Schnappinger, Dirk, Rock, Jeremy M.
Publicado 2021

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

por Li, Shuqi, Poulton, Nicholas C., Chang, Jesseon S., Azadian, Zachary A., DeJesus, Michael A., Ruecker, Nadine, Zimmerman, Matthew D., Eckartt, Kathryn A., Bosch, Barbara, Engelhart, Curtis A., Sullivan, Daniel F., Gengenbacher, Martin, Dartois, Véronique A., Schnappinger, Dirk, Rock, Jeremy M.
Publicado 2022

Chemical–genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

por Koh, Eun-Ik, Oluoch, Peter O., Ruecker, Nadine, Proulx, Megan K., Soni, Vijay, Murphy, Kenan C., Papavinasasundaram, Kadamba, Reames, Charlotte J., Trujillo, Carolina, Zaveri, Anisha, Zimmerman, Matthew D., Aslebagh, Roshanak, Baker, Richard E., Shaffer, Scott A., Guinn, Kristine M., Fitzgerald, Michael, Dartois, Véronique, Ehrt, Sabine, Hung, Deborah T., Ioerger, Thomas R., Rubin, Eric J., Rhee, Kyu Y., Schnappinger, Dirk, Sassetti, Christopher M.
Publicado 2022