The Future of Precision Oncology

por Rulten, Stuart L., Grose, Richard P., Gatz, Susanne A., Jones, J. Louise, Cameron, Angus J. M.
Publicado 2023

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function

por Breslin, Claire, Hornyak, Peter, Ridley, Andrew, Rulten, Stuart L., Hanzlikova, Hana, Oliver, Antony W., Caldecott, Keith W.
Publicado 2015

Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains

por Cherry, Amy L., Nott, Timothy J., Kelly, Geoffrey, Rulten, Stuart L., Caldecott, Keith W., Smerdon, Stephen J.
Publicado 2015

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

por Grundy, Gabrielle J., Rulten, Stuart L., Arribas-Bosacoma, Raquel, Davidson, Kathryn, Kozik, Zuzanna, Oliver, Antony W., Pearl, Laurence H., Caldecott, Keith W.
Publicado 2016

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage

por Rulten, Stuart L., Rotheray, Amy, Green, Ryan L., Grundy, Gabrielle J., Moore, Duncan A. Q., Gómez-Herreros, Fernando, Hafezparast, Majid, Caldecott, Keith W
Publicado 2014

Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures

por Komulainen, Emilia, Badman, Jack, Rey, Stephanie, Rulten, Stuart, Ju, Limei, Fennell, Kate, Kalasova, Ilona, Ilievova, Kristyna, McKinnon, Peter J, Hanzlikova, Hana, Staras, Kevin, Caldecott, Keith W
Publicado 2021

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2)

por Grundy, Gabrielle J., Polo, Luis M., Zeng, Zhihong, Rulten, Stuart L., Hoch, Nicolas C., Paomephan, Pathompong, Xu, Yingqi, Sweet, Steve M., Thorne, Alan W., Oliver, Antony W., Matthews, Steve J., Pearl, Laurence H., Caldecott, Keith W.
Publicado 2016

XRCC1 Mutation is Associated with PARP1 Hyperactivation and Cerebellar Ataxia

por Hoch, Nicolas, Hanzlikova, Hana, Rulten, Stuart L., Tétreault, Martine, Koumulainen, Emilia, Ju, Limei, Hornyak, Peter, Zeng, Zhihong, Gittens, William, Rey, Stephanie, Staras, Kevin, Mancini, Grazia M.S., McKinnon, Peter J., Wang, Zhao-Qi, Wagner, Justin, Yoon, Grace, Caldecott, Keith W.
Publicado 2016

Mouse and Human Genetic Analyses Associate Kalirin with Ventral Striatal Activation during Impulsivity and with Alcohol Misuse

por Peña-Oliver, Yolanda, Carvalho, Fabiana M., Sanchez-Roige, Sandra, Quinlan, Erin B., Jia, Tianye, Walker-Tilley, Tom, Rulten, Stuart L., Pearl, Frances M. G., Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Büchel, Christian, Conrod, Patricia J., Flor, Herta, Gallinat, Jürgen, Garavan, Hugh, Heinz, Andreas, Gowland, Penny, Paillere Martinot, Marie-Laure, Paus, Tomáš, Rietschel, Marcella, Robbins, Trevor W., Smolka, Michael N., Schumann, Gunter, Stephens, David N.
Publicado 2016