Beyond Antioxidant Effects: Nature-Based Templates Unveil New Strategies for Neurodegenerative Diseases

por Bacci, Andrea, Runfola, Massimiliano, Sestito, Simona, Rapposelli, Simona
Publicado 2021

New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective

por Sestito, Simona, Runfola, Massimiliano, Tonelli, Marco, Chiellini, Grazia, Rapposelli, Simona
Publicado 2018

Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics

por Runfola, Massimiliano, Sestito, Simona, Gul, Sheraz, Chiellini, Grazia, Rapposelli, Simona
Publicado 2020

Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders

por Saponaro, Federica, Sestito, Simona, Runfola, Massimiliano, Rapposelli, Simona, Chiellini, Grazia
Publicado 2020

Synthetic Thyroid Hormone Receptor-β Agonists Promote Oligodendrocyte Precursor Cell Differentiation in the Presence of Inflammatory Challenges

por Baldassarro, Vito Antonio, Quadalti, Corinne, Runfola, Massimiliano, Manera, Clementina, Rapposelli, Simona, Calzà, Laura
Publicado 2023

SUN-717 SG-2 a Novel Multi-Target Directed Ligand (MTDL) for the Treatment of Neurodegenerative Diseases (NDDS)

por Sestito, Simona, Runfola, Massimiliano, Bandini, Lavinia, Santucci, Filippo, Origlia, Nicola, Rapposelli, Simona, Chiellini, Grazia
Publicado 2020

Diphenyl-Methane Based Thyromimetic Inhibitors for Transthyretin Amyloidosis

por Kim, Bokyung, Ko, Young Ho, Runfola, Massimiliano, Rapposelli, Simona, Ortore, Gabriella, Chiellini, Grazia, Kim, Jin Hae
Publicado 2021

TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD

por Caddeo, Andrea, Kowalik, Marta Anna, Serra, Marina, Runfola, Massimiliano, Bacci, Andrea, Rapposelli, Simona, Columbano, Amedeo, Perra, Andrea
Publicado 2021

Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids

por Bacci, Andrea, Corsi, Francesca, Runfola, Massimiliano, Sestito, Simona, Piano, Ilaria, Manera, Clementina, Saccomanni, Giuseppe, Gargini, Claudia, Rapposelli, Simona
Publicado 2022

Potential role of two novel agonists of thyroid hormone receptor‐β on liver regeneration

por Perra, Andrea, Kowalik, Marta Anna, Cabras, Lavinia, Runfola, Massimiliano, Sestito, Simona, Migliore, Cristina, Giordano, Silvia, Chiellini, Grazia, Rapposelli, Simona, Columbano, Amedeo
Publicado 2020

Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-Like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents through the Modulation of SIRT6

por Bellusci, Lorenza, Runfola, Massimiliano, Carnicelli, Vittoria, Sestito, Simona, Fulceri, Federica, Santucci, Filippo, Lenzi, Paola, Fornai, Francesco, Rapposelli, Simona, Origlia, Nicola, Zucchi, Riccardo, Chiellini, Grazia
Publicado 2020

Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer’s Disease

por Runfola, Massimiliano, Perni, Michele, Yang, Xiaoting, Marchese, Maria, Bacci, Andrea, Mero, Serena, Santorelli, Filippo M., Polini, Beatrice, Chiellini, Grazia, Giuliani, Daniela, Vilella, Antonietta, Bodria, Martina, Daini, Eleonora, Vandini, Eleonora, Rudge, Simon, Gul, Sheraz, Wakelam, Michale O. J., Vendruscolo, Michele, Rapposelli, Simona
Publicado 2021