Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies

por Kawana, Masataka, Spudich, James A., Ruppel, Kathleen M.
Publicado 2022

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

por Kawana, Masataka, Sarkar, Saswata S., Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.
Publicado 2017

Controlling load-dependent kinetics of β-cardiac myosin at the single molecule level

por Liu, Chao, Kawana, Masataka, Song, Dan, Ruppel, Kathleen M., Spudich, James A.
Publicado 2018

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

por Aksel, Tural, Yu, Elizabeth Choe, Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.
Publicado 2015

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light

por Trivedi, Darshan V., Adhikari, Arjun S., Sarkar, Saswata S., Ruppel, Kathleen M., Spudich, James A.
Publicado 2017

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

por Morck, Makenna M, Bhowmik, Debanjan, Pathak, Divya, Dawood, Aminah, Spudich, James, Ruppel, Kathleen M
Publicado 2022

Effects of Troponin T Cardiomyopathy Mutations on the Calcium Sensitivity of the Regulated Thin Filament and the Actomyosin Cross-Bridge Kinetics of Human β-Cardiac Myosin

por Sommese, Ruth F., Nag, Suman, Sutton, Shirley, Miller, Susan M., Spudich, James A., Ruppel, Kathleen M.
Publicado 2013

Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules

por Sung, Jongmin, Nag, Suman, Mortensen, Kim I., Vestergaard, Christian L., Sutton, Shirley, Ruppel, Kathleen, Flyvbjerg, Henrik, Spudich, James A.
Publicado 2015

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

por Sarkar, Saswata S., Trivedi, Darshan V., Morck, Makenna M., Adhikari, Arjun S., Pasha, Shaik N., Ruppel, Kathleen M., Spudich, James A.
Publicado 2020

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

por Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Publicado 2019

Homologous mutations in [Formula: see text] , embryonic, and perinatal muscle myosins have divergent effects on molecular power generation

por Liu, Chao, Karabina, Anastasia, Meller, Artur, Bhattacharjee, Ayan, Agostino, Colby J, Bowman, Greg R, Ruppel, Kathleen M, Spudich, James A, Leinwand, Leslie A
Publicado 2023

Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin

por Pan, Stephen, Sommese, Ruth F., Sallam, Karim I., Nag, Suman, Sutton, Shirley, Miller, Susan M., Spudich, James A., Ruppel, Kathleen M., Ashley, Euan A.
Publicado 2015

Cryo-EM structure of the folded-back state of human β-cardiac myosin(*)

por Grinzato, Alessandro, Auguin, Daniel, Kikuti, Carlos, Nandwani, Neha, Moussaoui, Dihia, Pathak, Divya, Kandiah, Eaazhisai, Ruppel, Kathleen M., Spudich, James A., Houdusse, Anne, Robert-Paganin, Julien
Publicado 2023

Cryo-EM structure of the folded-back state of human β-cardiac myosin

por Grinzato, Alessandro, Auguin, Daniel, Kikuti, Carlos, Nandwani, Neha, Moussaoui, Dihia, Pathak, Divya, Kandiah, Eaazhisai, Ruppel, Kathleen M., Spudich, James A., Houdusse, Anne, Robert-Paganin, Julien
Publicado 2023

Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function

por Nag, Suman, Sommese, Ruth F., Ujfalusi, Zoltan, Combs, Ariana, Langer, Stephen, Sutton, Shirley, Leinwand, Leslie A., Geeves, Michael A., Ruppel, Kathleen M., Spudich, James A.
Publicado 2015

Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state

por Vander Roest, Alison Schroer, Liu, Chao, Morck, Makenna M., Kooiker, Kristina Bezold, Jung, Gwanghyun, Song, Dan, Dawood, Aminah, Jhingran, Arnav, Pardon, Gaspard, Ranjbarvaziri, Sara, Fajardo, Giovanni, Zhao, Mingming, Campbell, Kenneth S., Pruitt, Beth L., Spudich, James A., Ruppel, Kathleen M., Bernstein, Daniel
Publicado 2021