Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

por Rut, Wioletta, Zmudzinski, Mikolaj, Snipas, Scott J., Bekes, Miklos, Huang, Tony T., Drag, Marcin
Publicado 2020

A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

por Patchett, Stephanie, Lv, Zongyang, Rut, Wioletta, Békés, Miklos, Drag, Marcin, Olsen, Shaun K., Huang, Tony T.
Publicado 2021

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

por Poreba, Marcin, Rut, Wioletta, Vizovisek, Matej, Groborz, Katarzyna, Kasperkiewicz, Paulina, Finlay, Darren, Vuori, Kristiina, Turk, Dusan, Turk, Boris, Salvesen, Guy S., Drag, Marcin
Publicado 2018

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

por Rut, Wioletta, Lv, Zongyang, Zmudzinski, Mikolaj, Patchett, Stephanie, Nayak, Digant, Snipas, Scott J., El Oualid, Farid, Huang, Tony T., Bekes, Miklos, Drag, Marcin, Olsen, Shaun K.
Publicado 2020

Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families

por Poreba, Marcin, Szalek, Aleksandra, Rut, Wioletta, Kasperkiewicz, Paulina, Rutkowska-Wlodarczyk, Izabela, Snipas, Scott J., Itoh, Yoshifumi, Turk, Dusan, Turk, Boris, Overall, Christopher M., Kaczmarek, Leszek, Salvesen, Guy S., Drag, Marcin
Publicado 2017

Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts

por Strub, Daniel Jan, Talma, Michał, Strub, Maria, Rut, Wioletta, Zmudzinski, Mikolaj, Brud, Władysław, Neyts, Johan, Vangeel, Laura, Zhang, Linlin, Sun, Xinyuanyuan, Lv, Zongyang, Nayak, Digant, Olsen, Shaun K., Hilgenfeld, Rolf, Jochmans, Dirk, Drąg, Marcin
Publicado 2022

Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery

por Kryštůfek, Robin, Šácha, Pavel, Starková, Jana, Brynda, Jiří, Hradilek, Martin, Tloušt’ová, Eva, Grzymska, Justyna, Rut, Wioletta, Boucher, Michael J., Drąg, Marcin, Majer, Pavel, Hájek, Miroslav, Řezáčová, Pavlína, Madhani, Hiten D., Craik, Charles S., Konvalinka, Jan
Publicado 2021

Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PL(pro) and M(pro) proteases, and nsp14 guanine N7-methyltransferase

por Zmudzinski, Mikolaj, Rut, Wioletta, Olech, Kamila, Granda, Jarosław, Giurg, Mirosław, Burda-Grabowska, Małgorzata, Kaleta, Rafał, Zgarbova, Michala, Kasprzyk, Renata, Zhang, Linlin, Sun, Xinyuanyuan, Lv, Zongyang, Nayak, Digant, Kesik-Brodacka, Malgorzata, Olsen, Shaun K., Weber, Jan, Hilgenfeld, Rolf, Jemielity, Jacek, Drag, Marcin
Publicado 2023

SARS-CoV-2 M(pro) Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals

por Chen, Sizhu Amelia, Arutyunova, Elena, Lu, Jimmy, Khan, Muhammad Bashir, Rut, Wioletta, Zmudzinski, Mikolaj, Shahbaz, Shima, Iyyathurai, Jegan, Moussa, Eman W., Turner, Zoe, Bai, Bing, Lamer, Tess, Nieman, James A., Vederas, John C., Julien, Olivier, Drag, Marcin, Elahi, Shokrollah, Young, Howard S., Lemieux, M. Joanne
Publicado 2023

Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL(pro) substrate degradome

por Pablos, Isabel, Machado, Yoan, de Jesus, Hugo C. Ramos, Mohamud, Yasir, Kappelhoff, Reinhild, Lindskog, Cecilia, Vlok, Marli, Bell, Peter A., Butler, Georgina S., Grin, Peter M., Cao, Quynh T., Nguyen, Jenny P., Solis, Nestor, Abbina, Srinivas, Rut, Wioletta, Vederas, John C., Szekely, Laszlo, Szakos, Attila, Drag, Marcin, Kizhakkedathu, Jayachandran N., Mossman, Karen, Hirota, Jeremy A., Jan, Eric, Luo, Honglin, Banerjee, Arinjay, Overall, Christopher M.
Publicado 2021

Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections

por Reinke, Patrick Y. A., de Souza, Edmarcia Elisa, Günther, Sebastian, Falke, Sven, Lieske, Julia, Ewert, Wiebke, Loboda, Jure, Herrmann, Alexander, Rahmani Mashhour, Aida, Karničar, Katarina, Usenik, Aleksandra, Lindič, Nataša, Sekirnik, Andreja, Botosso, Viviane Fongaro, Santelli, Gláucia Maria Machado, Kapronezai, Josana, de Araújo, Marcelo Valdemir, Silva-Pereira, Taiana Tainá, Filho, Antônio Francisco de Souza, Tavares, Mariana Silva, Flórez-Álvarez, Lizdany, de Oliveira, Danielle Bruna Leal, Durigon, Edison Luiz, Giaretta, Paula Roberta, Heinemann, Marcos Bryan, Hauser, Maurice, Seychell, Brandon, Böhler, Hendrik, Rut, Wioletta, Drag, Marcin, Beck, Tobias, Cox, Russell, Chapman, Henry N., Betzel, Christian, Brehm, Wolfgang, Hinrichs, Winfried, Ebert, Gregor, Latham, Sharissa L., Guimarães, Ana Marcia de Sá, Turk, Dusan, Wrenger, Carsten, Meents, Alke
Publicado 2023