Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from c...

por Zhang, Weiguo, Ly, Charlie, Ishizawa, Jo, Mu, Hong, Ruvolo, Vivian, Shacham, Sharon, Daver, Naval, Andreeff, Michael
Publicado 2018

Role for PKC δ in Fenretinide-Mediated Apoptosis in Lymphoid Leukemia Cells

por Ruvolo, Vivian R., Karanjeet, Kul B., Schuster, Todd F., Brown, Rhoderick, Deng, Yibin, Hinchcliffe, Edward, Ruvolo, Peter P.
Publicado 2010

Bone marrow stromal cells induce an ALDH(+) stem cell-like phenotype and enhance therapy resistance in AML through a TGF-β-p38-ALDH2 pathway

por Yuan, Bin, El Dana, Fouad, Ly, Stanley, Yan, Yuanqing, Ruvolo, Vivian, Shpall, Elizabeth J., Konopleva, Marina, Andreeff, Michael, Battula, Venkata Lokesh
Publicado 2020

Low Expression Of PP2A Regulatory Subunit B55α Is Associated With T308 Phosphorylation Of AKT And Shorter Complete Remission Duration In Acute Myeloid Leukemia Patients

por Ruvolo, Peter P., Qui, YiHua, Coombes, Kevin R., Zhang, Nianxiang, Ruvolo, Vivian R., Borthakur, Gautam, Konopleva, Marina, Andreeff, Michael, Kornblau, Steven M.
Publicado 2011

Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and re-sensitizes acute myeloid leukemia to BCL-2 inhibition

por Carter, Bing Z., Mak, Po Yee, Tao, Wenjing, Warmoes, Marc, Lorenzi, Philip L., Mak, Duncan, Ruvolo, Vivian, Tan, Lin, Cidado, Justin, Drew, Lisa, Andreeff, Michael
Publicado 2020

MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation

por Borthakur, Gautam, Duvvuri, Seshagiri, Ruvolo, Vivian, Tripathi, Durga Nand, Piya, Sujan, Burks, Jared, Jacamo, Rodrigo, Kojima, Kensuke, Ruvolo, Peter, Fueyo-Margareto, Juan, Konopleva, Marina, Andreeff, Michael
Publicado 2015

Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression

por Steelman, Linda S., Abrams, Steve L., Ruvolo, Peter, Ruvolo, Vivian, Cocco, Lucio, Ratti, Stefano, Martelli, Alberto M., Neri, Luca M., Candido, Saverio, Libra, Massimo, McCubrey, James A.
Publicado 2017

Phosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients

por Ruvolo, Peter P., Qiu, YiHua, Coombes, Kevin R., Zhang, Nianxiang, Neeley, E. Shannon, Ruvolo, Vivian R., Hail, Numsen, Borthakur, Gautam, Konopleva, Marina, Andreeff, Michael, Kornblau, Steven M.
Publicado 2015

Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mec...

por Ruvolo, Peter P., Ma, Huaxian, Ruvolo, Vivian R., Zhang, Xiaorui, Mu, Hong, Schober, Wendy, Hernandez, Ivonne, Gallardo, Miguel, Khoury, Joseph D., Cortes, Jorge, Andreeff, Michael, Post, Sean M.
Publicado 2017

LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML

por Ruvolo, Peter P., Hu, Chenyue W., Qiu, Yihua, Ruvolo, Vivian R., Go, Robin L., Hubner, Stefan E., Coombes, Kevin R., Andreeff, Michael, Qutub, Amina A., Kornblau, Steven M.
Publicado 2019

Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34(+) proliferating and quiescent chronic myeloid leukemia blast c...

por Carter, Bing Z., Mak, Po Yee, Mak, Duncan H., Ruvolo, Vivian R., Schober, Wendy, McQueen, Teresa, Cortes, Jorge, Kantarjian, Hagop M., Champlin, Richard E., Konopleva, Marina, Andreeff, Michael
Publicado 2015

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network

por Carter, Bing Z., Mak, Po Yee, Chen, Ye, Mak, Duncan H., Mu, Hong, Jacamo, Rodrigo, Ruvolo, Vivian, Arold, Stefan T., Ladbury, John E., Burks, Jared K., Kornblau, Steven, Andreeff, Michael
Publicado 2016

Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine

por Tabe, Yoko, Saitoh, Kaori, Yang, Haeun, Sekihara, Kazumasa, Yamatani, Kotoko, Ruvolo, Vivian, Taka, Hikari, Kaga, Naoko, Kikkawa, Mika, Arai, Hajime, Miida, Takashi, Andreeff, Michael, Spagnuolo, Paul A., Konopleva, Marina
Publicado 2018

Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells

por Abrams, Stephen L., Ruvolo, Peter P., Ruvolo, Vivian R., Ligresti, Giovanni, Martelli, Alberto M., Cocco, Lucio, Ratti, Stefano, Tafuri, Agostino, Steelman, Linda S., Candido, Saverio, Libra, Massimo, McCubrey, James A.
Publicado 2017

Genetic biomarkers of sensitivity and resistance to venetoclax monotherapy in patients with relapsed acute myeloid leukemia

por Chyla, Brenda, Daver, Naval, Doyle, Kelly, McKeegan, Evelyn, Huang, Xin, Ruvolo, Vivian, Wang, Zixing, Chen, Ken, Souers, Andrew, Leverson, Joel, Potluri, Jalaja, Boghaert, Erwin, Bhathena, Anahita, Konopleva, Marina, Popovic, Relja
Publicado 2018

Concomitant targeting of FLT3 and BTK overcomes FLT3 inhibitor resistance in acute myeloid leukemia through the inhibition of autophagy

por Zhang, Weiguo, Yu, Guopan, Zhang, Hongying, Basyal, Mahesh, Ly, Charlie, Yuan, Bin, Ruvolo, Vivian, Piya, Sujan, Bhattacharya, Seemana, Zhang, Qi, Borthakur, Gautam, Battula, Venkata L., Konopleva, Marina, Rice, William G., Andreeff, Michael
Publicado 2022

Mitochondrial Profiling of Acute Myeloid Leukemia in the Assessment of Response to Apoptosis Modulating Drugs

por Ishizawa, Jo, Kojima, Kensuke, McQueen, Teresa, Ruvolo, Vivian, Chachad, Dhruv, Nogueras-Gonzalez, Graciela M., Huang, Xuelin, Pierceall, William E., Dettman, E. J., Cardone, Michael H., Shacham, Sharon, Konopleva, Marina, Andreeff, Michael
Publicado 2015

Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma

por Yoshimura, Mariko, Ishizawa, Jo, Ruvolo, Vivian, Dilip, Archana, Quintás-Cardama, Alfonso, McDonnell, Timothy J, Neelapu, Sattva S, Kwak, Larry W, Shacham, Sharon, Kauffman, Michael, Tabe, Yoko, Yokoo, Masako, Kimura, Shinya, Andreeff, Michael, Kojima, Kensuke
Publicado 2014

Targeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL

por Piya, Sujan, Yang, Yaling, Bhattacharya, Seemana, Sharma, Priyanka, Ma, Huaxian, Mu, Hong, He, Hua, Ruvolo, Vivian, Baran, Natalia, Davis, R. Eric, Jain, Abhinav K., Konopleava, Marina, Kantarjian, Hagop, Andreeff, Michael, You, M. James, Borthakur, Gautam
Publicado 2022

Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia

por Jacamo, Rodrigo, Davis, R. Eric, Ling, Xiaoyang, Sonnylal, Sonali, Wang, Zhiqiang, Ma, Wencai, Zhang, Min, Ruvolo, Peter, Ruvolo, Vivian, Wang, Rui-Yu, McQueen, Teresa, Lowe, Scott, Zuber, Johannes, Kornblau, Steven M., Konopleva, Marina, Andreeff, Michael
Publicado 2017