Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases

por Ryan, Brent J., Nissim, Ahuva, Winyard, Paul G.
Publicado 2014

Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

por Fernandes, Hugo J. R., Ryan, Brent J., Wade-Martins, Richard
Publicado 2016

Protein-protein interaction networks identify targets which rescue the MPP(+) cellular model of Parkinson’s disease

por Keane, Harriet, Ryan, Brent J., Jackson, Brendan, Whitmore, Alan, Wade-Martins, Richard
Publicado 2015

Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase

por Finelli, Mattéa J., Paramo, Teresa, Pires, Elisabete, Ryan, Brent J., Wade-Martins, Richard, Biggin, Philip C., McCullagh, James, Oliver, Peter L.
Publicado 2018

Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis

por Burska, Agata N., Hunt, Laura, Boissinot, Marjorie, Strollo, Rocky, Ryan, Brent J., Vital, Ed, Nissim, Ahuva, Winyard, Paul G., Emery, Paul, Ponchel, Frederique
Publicado 2014

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance

por Bailey, Jade, Shaw, Andrew, Fischer, Roman, Ryan, Brent J., Kessler, Benedikt M., McCullagh, James, Wade-Martins, Richard, Channon, Keith M., Crabtree, Mark J.
Publicado 2017

Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders

por Lai, Mang Ching, Bechy, Anne-Laure, Denk, Franziska, Collins, Emma, Gavriliouk, Maria, Zaugg, Judith B., Ryan, Brent J., Wade-Martins, Richard, Caffrey, Tara M.
Publicado 2017

A requirement for Gch1 and tetrahydrobiopterin in embryonic development

por Douglas, Gillian, Hale, Ashley B., Crabtree, Mark J, Ryan, Brent J., Hansler, Alex, Watschinger, Katrin, Gross, Steven S, Lygate, Craig A., Alp, Nicholas J., Channon, Keith M.
Publicado 2015

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

por Hasan, Saadia, Fernandopulle, Michael S., Humble, Stewart W., Frankenfield, Ashley M., Li, Haorong, Prestil, Ryan, Johnson, Kory R., Ryan, Brent J., Wade-Martins, Richard, Ward, Michael E., Hao, Ling
Publicado 2023

Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons

por Hasan, Saadia, Fernandopulle, Michael S., Humble, Stewart W., Frankenfield, Ashley M., Li, Haorong, Prestil, Ryan, Johnson, Kory R., Ryan, Brent J., Wade-Martins, Richard, Ward, Michael E., Hao, Ling
Publicado 2023

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells

por Smith, Amy M., Depp, Constanze, Ryan, Brent J., Johnston, Geoffrey I., Alegre‐Abarrategui, Javier, Evetts, Samuel, Rolinski, Michal, Baig, Fahd, Ruffmann, Claudio, Simon, Anna Katharina, Hu, Michele T. M., Wade‐Martins, Richard
Publicado 2018

Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism

por Okarmus, Justyna, Havelund, Jesper F., Ryding, Matias, Schmidt, Sissel I., Bogetofte, Helle, Heon-Roberts, Rachel, Wade-Martins, Richard, Cowley, Sally A., Ryan, Brent J., Færgeman, Nils J., Hyttel, Poul, Meyer, Morten
Publicado 2021

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes

por Lang, Charmaine, Campbell, Kieran R., Ryan, Brent J., Carling, Phillippa, Attar, Moustafa, Vowles, Jane, Perestenko, Olga V., Bowden, Rory, Baig, Fahd, Kasten, Meike, Hu, Michele T., Cowley, Sally A., Webber, Caleb, Wade-Martins, Richard
Publicado 2019

Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function

por Carling, Phillippa J, Ryan, Brent J, McGuinness, William, Kataria, Shikha, Humble, Stewart W, Milde, Stefan, Duce, James A, Kapadia, Nirav, Zuercher, William J, Davis, John B., Di Daniel, Elena, Wade-Martins, Richard
Publicado 2022

Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol

por Threlfell, Sarah, Mohammadi, Amir Saeid, Ryan, Brent J., Connor-Robson, Natalie, Platt, Nicola J., Anand, Rishi, Serres, Florence, Sharp, Trevor, Bengoa-Vergniory, Nora, Wade-Martins, Richard, Ewing, Andrew, Cragg, Stephanie J., Brimblecombe, Katherine R.
Publicado 2021

PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

por Bogetofte, Helle, Jensen, Pia, Ryding, Matias, Schmidt, Sissel I., Okarmus, Justyna, Ritter, Louise, Worm, Christina S., Hohnholt, Michaela C., Azevedo, Carla, Roybon, Laurent, Bak, Lasse K., Waagepetersen, Helle, Ryan, Brent J., Wade-Martins, Richard, Larsen, Martin R., Meyer, Morten
Publicado 2019

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons

por Zambon, Federico, Cherubini, Marta, Fernandes, Hugo J R, Lang, Charmaine, Ryan, Brent J, Volpato, Viola, Bengoa-Vergniory, Nora, Vingill, Siv, Attar, Moustafa, Booth, Heather D E, Haenseler, Walther, Vowles, Jane, Bowden, Rory, Webber, Caleb, Cowley, Sally A, Wade-Martins, Richard
Publicado 2019

Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson’s disease models

por Williamson, Matthew G, Madureira, Marta, McGuinness, William, Heon-Roberts, Rachel, Mock, Elliot D, Naidoo, Kalina, Cramb, Kaitlyn M L, Caiazza, Maria-Claudia, Malpartida, Ana B, Lavelle, Martha, Savory, Katrina, Humble, Stewart W, Patterson, Ryan, Davis, John B, Connor-Robson, Natalie, Ryan, Brent J, Wade-Martins, Richard
Publicado 2023

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

por Fernandes, Hugo J.R., Hartfield, Elizabeth M., Christian, Helen C., Emmanoulidou, Evangelia, Zheng, Ying, Booth, Heather, Bogetofte, Helle, Lang, Charmaine, Ryan, Brent J., Sardi, S. Pablo, Badger, Jennifer, Vowles, Jane, Evetts, Samuel, Tofaris, George K., Vekrellis, Kostas, Talbot, Kevin, Hu, Michele T., James, William, Cowley, Sally A., Wade-Martins, Richard
Publicado 2016