Troponin-I–induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle

por Lehman, William, Rynkiewicz, Michael J.
Publicado 2023

Modeling Human Cardiac Thin Filament Structures

por Rynkiewicz, Michael J., Pavadai, Elumalai, Lehman, William
Publicado 2022

Molecular modeling of apoE in complexes with Alzheimer’s amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids

por Lewkowicz, Emily, Nakamura, Mari N., Rynkiewicz, Michael J., Gursky, Olga
Publicado 2023

Tropomyosin diffusion over actin subunits facilitates thin filament assembly

por Fischer, Stefan, Rynkiewicz, Michael J., Moore, Jeffrey R., Lehman, William
Publicado 2016

Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states

por Kiani, Farooq A., Lehman, William, Fischer, Stefan, Rynkiewicz, Michael J.
Publicado 2019

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

por Viswanathan, Meera C., Schmidt, William, Rynkiewicz, Michael J., Agarwal, Karuna, Gao, Jian, Katz, Joseph, Lehman, William, Cammarato, Anthony
Publicado 2017

Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L

por Halder, Saiti S, Rynkiewicz, Michael J, Creso, Jenette G, Sewanan, Lorenzo R, Howland, Lindsey, Moore, Jeffrey R, Lehman, William, Campbell, Stuart G
Publicado 2023

A role for actin flexibility in thin filament-mediated contractile regulation and myopathy

por Viswanathan, Meera C., Schmidt, William, Franz, Peter, Rynkiewicz, Michael J., Newhard, Christopher S., Madan, Aditi, Lehman, William, Swank, Douglas M., Preller, Matthias, Cammarato, Anthony
Publicado 2020

Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1

por Janco, Miro, Rynkiewicz, Michael J., Li, Liang, Hook, Jeff, Eiffe, Eleanor, Ghosh, Anita, Böcking, Till, Lehman, William J., Hardeman, Edna C., Gunning, Peter W.
Publicado 2019

Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation

por Doran, Matthew H., Rynkiewicz, Michael J., Pavadai, Elumalai, Bodt, Skylar M.L., Rasicci, David, Moore, Jeffrey R., Yengo, Christopher M., Bullitt, Esther, Lehman, William
Publicado 2022

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

por Doran, Matthew H., Rynkiewicz, Michael J., Rasicci, David, Bodt, Skylar M.L., Barry, Meaghan E., Bullitt, Esther, Yengo, Christopher M., Moore, Jeffrey R., Lehman, William
Publicado 2023

Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation

por Sewanan, Lorenzo R., Park, Jinkyu, Rynkiewicz, Michael J., Racca, Alice W., Papoutsidakis, Nikolaos, Schwan, Jonas, Jacoby, Daniel L., Moore, Jeffrey R., Lehman, William, Qyang, Yibing, Campbell, Stuart G.
Publicado 2021

B-Cell Epitopes in GroEL of Francisella tularensis

por Lu, Zhaohua, Rynkiewicz, Michael J., Madico, Guillermo, Li, Sheng, Yang, Chiou-Ying, Perkins, Hillary M., Sompuram, Seshi R., Kodela, Vani, Liu, Tong, Morris, Timothy, Wang, Daphne, Roche, Marly I., Seaton, Barbara A., Sharon, Jacqueline
Publicado 2014

Enhanced Antiviral Activity of Human Surfactant Protein D by Site-Specific Engineering of the Carbohydrate Recognition Domain

por van Eijk, Martin, Hillaire, Marine L. B., Rimmelzwaan, Guus F., Rynkiewicz, Michael J., White, Mitchell R., Hartshorn, Kevan L., Hessing, Martin, Koolmees, Peter A., Tersteeg, Monique H., van Es, Maarten H., Meijerhof, Tjarko, Huckriede, Anke, Haagsman, Henk P.
Publicado 2019

Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry

por Patel, Devanshi, Mez, Jesse, Vardarajan, Badri N., Staley, Lyndsay, Chung, Jaeyoon, Zhang, Xiaoling, Farrell, John J., Rynkiewicz, Michael J., Cannon-Albright, Lisa A., Teerlink, Craig C., Stevens, Jeffery, Corcoran, Christopher, Gonzalez Murcia, Josue D., Lopez, Oscar L., Mayeux, Richard, Haines, Jonathan L., Pericak-Vance, Margaret A., Schellenberg, Gerard, Kauwe, John S. K., Lunetta, Kathryn L., Farrer, Lindsay A.
Publicado 2019

Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability

por Teekakirikul, Polakit, Zhu, Wenjuan, Xu, Xinxiu, Young, Cullen B., Tan, Tuantuan, Smith, Amanda M., Wang, Chengdong, Peterson, Kevin A., Gabriel, George C., Ho, Sebastian, Sheng, Yi, Moreau de Bellaing, Anne, Sonnenberg, Daniel A., Lin, Jiuann-huey, Fotiou, Elisavet, Tenin, Gennadiy, Wang, Michael X., Wu, Yijen L., Feinstein, Timothy, Devine, William, Gou, Honglan, Bais, Abha S., Glennon, Benjamin J., Zahid, Maliha, Wong, Timothy C., Ahmad, Ferhaan, Rynkiewicz, Michael J., Lehman, William J., Keavney, Bernard, Alastalo, Tero-Pekka, Freckmann, Mary-Louise, Orwig, Kyle, Murray, Steve, Ware, Stephanie M., Zhao, Hui, Feingold, Brian, Lo, Cecilia W.
Publicado 2022