Rapid modeling of cooperating genetic events in cancer through somatic genome editing

por Sánchez-Rivera, Francisco J., Papagiannakopoulos, Thales, Romero, Rodrigo, Tammela, Tuomas, Bauer, Matthew R., Bhutkar, Arjun, Joshi, Nikhil S., Subbaraj, Lakshmipriya, Bronson, Roderick T., Xue, Wen, Jacks, Tyler
Publicado 2014

Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

por Sánchez-Rivera, Francisco J., Ryan, Jeremy, Soto-Feliciano, Yadira M., Clare Beytagh, Mary, Xuan, Lucius, Feldser, David M., Hemann, Michael T., Zamudio, Jesse, Dimitrova, Nadya, Letai, Anthony, Jacks, Tyler
Publicado 2021

Stage-specific sensitivity to p53 restoration during lung cancer progression

por Feldser, David M., Kostova, Kamena K., Winslow, Monte M., Taylor, Sarah E., Cashman, Chris, Whittaker, Charles A., Sanchez-Rivera, Francisco J., Resnick, Rebecca, Bronson, Roderick, Hemann, Michael T., Jacks, Tyler
Publicado 2010

PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes

por Soto-Feliciano, Yadira M., Bartlebaugh, Jordan M.E., Liu, Yunpeng, Sánchez-Rivera, Francisco J., Bhutkar, Arjun, Weintraub, Abraham S., Buenrostro, Jason D., Cheng, Christine S., Regev, Aviv, Jacks, Tyler E., Young, Richard A., Hemann, Michael T.
Publicado 2017

Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability

por Benabdallah, Nezha S., Dalal, Vineet, Scott, R. Wilder, Marcous, Fady, Sotiriou, Afroditi, Kommoss, Felix K. F., Pejkovska, Anastasija, Gaspar, Ludmila, Wagner, Lena, Sánchez-Rivera, Francisco J., Ta, Monica, Thornton, Shelby, Nielsen, Torsten O., Underhill, T. Michael, Banito, Ana
Publicado 2023

Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma

por Chen, Xiao, Li, Yinglu, Zhu, Fang, Xu, Xinjing, Estrella, Brian, Pazos, Manuel A., McGuire, John T., Karagiannis, Dimitris, Sahu, Varun, Mustafokulov, Mustafo, Scuoppo, Claudio, Sánchez-Rivera, Francisco J., Soto-Feliciano, Yadira M., Pasqualucci, Laura, Ciccia, Alberto, Amengual, Jennifer E., Lu, Chao
Publicado 2023

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

por Tammela, Tuomas, Sanchez-Rivera, Francisco J., Cetinbas, Naniye Malli, Wu, Katherine, Joshi, Nikhil S., Helenius, Katja, Park, Yoona, Azimi, Roxana, Kerper, Natanya R., Wesselhoeft, R. Alexander, Gu, Xin, Schmidt, Leah, Cornwall-Brady, Milton, Yilmaz, Ömer H., Xue, Wen, Katajisto, Pekka, Bhutkar, Arjun, Jacks, Tyler
Publicado 2017

Phase and context shape the function of composite oncogenic mutations

por Gorelick, Alexander N., Sánchez-Rivera, Francisco J., Cai, Yanyan, Bielski, Craig M., Biederstedt, Evan, Jonsson, Philip, Richards, Allison L., Vasan, Neil, Penson, Alexander V., Friedman, Noah D., Ho, Yu-Jui, Baslan, Timour, Bandlamudi, Chaitanya, Scaltriti, Maurizio, Schultz, Nikolaus, Lowe, Scott W., Reznik, Ed, Taylor, Barry S.
Publicado 2020

Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks

por Schneider, William M., Luna, Joseph M., Hoffmann, H.-Heinrich, Sánchez-Rivera, Francisco J., Leal, Andrew A., Ashbrook, Alison W., Le Pen, Jérémie, Ricardo-Lax, Inna, Michailidis, Eleftherios, Peace, Avery, Stenzel, Ansgar F., Lowe, Scott W., MacDonald, Margaret R., Rice, Charles M., Poirier, John T.
Publicado 2021

Optimized base editors enable efficient editing in cells, organoids and mice

por Zafra, Maria Paz, Schatoff, Emma M, Katti, Alyna, Foronda, Miguel, Breinig, Marco, Schweitzer, Anabel Y., Simon, Amber, Han, Teng, Goswami, Sukanya, Montgomery, Emma, Thibado, Jordana, Kastenhuber, Edward R, Sánchez-Rivera, Francisco J., Shi, Junwei, Vakoc, Christopher R, Lowe, Scott W, Tschaharganeh, Darjus F., Dow, Lukas E
Publicado 2018

SOAT1 promotes mevalonate pathway dependency in pancreatic cancer

por Oni, Tobiloba E., Biffi, Giulia, Baker, Lindsey A., Hao, Yuan, Tonelli, Claudia, Somerville, Tim D.D., Deschênes, Astrid, Belleau, Pascal, Hwang, Chang-il, Sánchez-Rivera, Francisco J., Cox, Hilary, Brosnan, Erin, Doshi, Abhishek, Lumia, Rebecca P., Khaledi, Kimia, Park, Youngkyu, Trotman, Lloyd C., Lowe, Scott W., Krasnitz, Alexander, Vakoc, Christopher R., Tuveson, David A.
Publicado 2020

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

por Hoffmann, H.-Heinrich, Sánchez-Rivera, Francisco J., Schneider, William M., Luna, Joseph M., Soto-Feliciano, Yadira M., Ashbrook, Alison W., Le Pen, Jérémie, Leal, Andrew A., Ricardo-Lax, Inna, Michailidis, Eleftherios, Hao, Yuan, Stenzel, Ansgar F., Peace, Avery, Zuber, Johannes, Allis, C. David, Lowe, Scott W., MacDonald, Margaret R., Poirier, John T., Rice, Charles M.
Publicado 2021

A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets

por Li, Xiang, Huang, Chun-Hao, Sánchez-Rivera, Francisco J., Kennedy, Margaret C., Tschaharganeh, Darjus F., Morris, John P., Montinaro, Antonella, O'Rourke, Kevin P., Banito, Ana, Wilkinson, John E., Chen, Chi-Chao, Ho, Yu-Jui, Dow, Lukas E., Tian, Sha, Luan, Wei, de Stanchina, Elisa, Zhang, Tinghu, Gray, Nathanael S., Walczak, Henning, Lowe, Scott W.
Publicado 2022

Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

por Sánchez-Rivera, Francisco J., Diaz, Bianca J., Kastenhuber, Edward R., Schmidt, Henri, Katti, Alyna, Kennedy, Margaret, Tem, Vincent, Ho, Yu-Jui, Leibold, Josef, Paffenholz, Stella V., Barriga, Francisco M., Chu, Kevan, Goswami, Sukanya, Wuest, Alexandra N., Simon, Janelle M., Tsanov, Kaloyan M., Chakravarty, Debyani, Zhang, Hongxin, Leslie, Christina S., Lowe, Scott W., Dow, Lukas E.
Publicado 2022

TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion

por Shakiba, Mojdeh, Zumbo, Paul, Espinosa-Carrasco, Gabriel, Menocal, Laura, Dündar, Friederike, Carson, Sandra E., Bruno, Emmanuel M., Sanchez-Rivera, Francisco J., Lowe, Scott W., Camara, Steven, Koche, Richard P., Reuter, Vincent P., Socci, Nicholas D., Whitlock, Benjamin, Tamzalit, Fella, Huse, Morgan, Hellmann, Matthew D., Wells, Daniel K., Defranoux, Nadine A., Betel, Doron, Philip, Mary, Schietinger, Andrea
Publicado 2021

A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition

por Soto-Feliciano, Yadira M., Sánchez-Rivera, Francisco J., Perner, Florian, Barrows, Douglas W., Kastenhuber, Edward R., Ho, Yu-Jui, Carroll, Thomas, Xiong, Yijun, Anand, Disha, Soshnev, Alexey A., Gates, Leah, Beytagh, Mary Clare, Cheon, David, Gu, Shengqing, Liu, X. Shirley, Krivtsov, Andrei V., Meneses, Maximiliano, de Stanchina, Elisa, Stone, Richard M., Armstrong, Scott A., Lowe, Scott W., Allis, C. David
Publicado 2023

Replication and single-cycle delivery of SARS-CoV-2 replicons

por Ricardo-Lax, Inna, Luna, Joseph M., Thao, Tran Thi Nhu, Le Pen, Jérémie, Yu, Yingpu, Hoffmann, H.-Heinrich, Schneider, William M., Razooky, Brandon S., Fernandez-Martinez, Javier, Schmidt, Fabian, Weisblum, Yiska, Trüeb, Bettina Salome, Berenguer Veiga, Inês, Schmied, Kimberly, Ebert, Nadine, Michailidis, Eleftherios, Peace, Avery, Sánchez-Rivera, Francisco J., Lowe, Scott W., Rout, Michael P., Hatziioannou, Theodora, Bieniasz, Paul D., Poirier, John T., MacDonald, Margaret R., Thiel, Volker, Rice, Charles M.
Publicado 2021

Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis

por Romero, Rodrigo, Sayin, Volkan I., Davidson, Shawn M., Bauer, Matthew R., Singh, Simranjit X., LeBoeuf, Sarah E., Karakousi, Triantafyllia R., Ellis, Donald C., Bhutkar, Arjun, Sanchez-Rivera, Francisco J., Subbaraj, Lakshmipriya, Martinez, Britney, Bronson, Roderick T., Prigge, Justin R., Schmidt, Edward E., Thomas, Craig J., Goparaju, Chandra, Davies, Angela, Dolgalev, Igor, Heguy, Adriana, Allaj, Viola, Poirier, John T., Moreira, Andre L., Rudin, Charles M., Pass, Harvey I., Vander Heiden, Matthew G., Jacks, Tyler, Papagiannakopoulos, Thales
Publicado 2017