Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy

por Diness, Jonas G., Bentzen, Bo H., Sørensen, Ulrik S., Grunnet, Morten
Publicado 2015

2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels

por Simó-Vicens, Rafel, Bomholtz, Sofia H., Sørensen, Ulrik S., Bentzen, Bo H.
Publicado 2018

The K(Ca)2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in Conscious Pigs

por Diness, Jonas Goldin, Kirchhoff, Jeppe Egedal, Speerschneider, Tobias, Abildgaard, Lea, Edvardsson, Nils, Sørensen, Ulrik S., Grunnet, Morten, Bentzen, Bo Hjorth
Publicado 2020

Inhibition of K(Ca)2 Channels Decreased the Risk of Ventricular Arrhythmia in the Guinea Pig Heart During Induced Hypokalemia

por Diness, Jonas Goldin, Abildgaard, Lea, Bomholtz, Sofia Hammami, Skarsfeldt, Mark Alexander, Edvardsson, Nils, Sørensen, Ulrik S., Grunnet, Morten, Bentzen, Bo Hjorth
Publicado 2020

Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man

por Bentzen, Bo Hjorth, Bomholtz, Sofia Hammami, Simó-Vicens, Rafel, Folkersen, Lasse, Abildgaard, Lea, Speerschneider, Tobias, Muthukumarasamy, Kalai Mangai, Edvardsson, Nils, Sørensen, Ulrik S., Grunnet, Morten, Diness, Jonas Goldin
Publicado 2020

Effective termination of atrial fibrillation by SK channel inhibition is associated with a sudden organization of fibrillatory conduction

por Gatta, Giulia, Sobota, Vladimir, Citerni, Carlotta, Diness, Jonas Goldin, Sørensen, Ulrik S, Jespersen, Thomas, Bentzen, Bo Hjorth, Zeemering, Stef, Kuiper, Marion, Verheule, Sander, Schotten, Ulrich, van Hunnik, Arne
Publicado 2021

The K(Ca)2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts

por Kirchhoff, Jeppe Egedal, Skarsfeldt, Mark Alexander, Muthukumarasamy, Kalai Mangai, Simó-Vicens, Rafel, Bomholtz, Sofia Hammami, Abildgaard, Lea, Jespersen, Thomas, Sørensen, Ulrik S., Grunnet, Morten, Bentzen, Bo Hjorth, Diness, Jonas Goldin
Publicado 2019

First Clinical Study with AP30663 ‐ a K(Ca)2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation

por Gal, Pim, Klaassen, Erica S., Bergmann, Kirsten R., Saghari, Mahdi, Burggraaf, Jacobus, Kemme, Michiel J. B., Sylvest, Christina, Sørensen, Ulrik, Bentzen, Bo H., Grunnet, Morten, Diness, Jonas G., Edvardsson, Nils
Publicado 2020

Inhibition of Small-Conductance Calcium-Activated Potassium Current (I(K,Ca)) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibril...

por Fenner, Merle Friederike, Gatta, Giulia, Sattler, Stefan, Kuiper, Marion, Hesselkilde, Eva Melis, Adler, Ditte M. T., Smerup, Morten, Schotten, Ulrich, Sørensen, Ulrik, Diness, Jonas Goldin, Jespersen, Thomas, Verheule, Sander, Van Hunnik, Arne, Buhl, Rikke
Publicado 2021

Increased fibroblast accumulation in the equine heart following persistent atrial fibrillation

por Saljic, Arnela, Friederike Fenner, Merle, Winters, Joris, Flethøj, Mette, Eggert Eggertsen, Caroline, Carstensen, Helena, Dalgas Nissen, Sarah, Melis Hesselkilde, Eva, van Hunnik, Arne, Schotten, Ulrich, Sørensen, Ulrik, Jespersen, Thomas, Verheule, Sander, Buhl, Rikke
Publicado 2021

Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca(2+)-Activated K(+) Channels in Pigs

por Diness, Jonas Goldin, Skibsbye, Lasse, Simó-Vicens, Rafel, Santos, Joana Larupa, Lundegaard, Pia, Citerni, Carlotta, Sauter, Daniel Rafael Peter, Bomholtz, Sofia Hammami, Svendsen, Jesper Hastrup, Olesen, Søren-Peter, Sørensen, Ulrik S., Jespersen, Thomas, Grunnet, Morten, Bentzen, Bo Hjorth
Publicado 2017