Centrosome – a promising anti-cancer target

por Rivera-Rivera, Yainyrette, Saavedra, Harold I
Publicado 2016

Cdk4 and Nek2 Signal Binucleation and Centrosome Amplification in a Her2+ Breast Cancer Model

por Harrison Pitner, Mary Kathryn, Saavedra, Harold I.
Publicado 2013

Silencing of E2F3 suppresses tumor growth of Her2(+) breast cancer cells by restricting mitosis

por Lee, Miyoung, Oprea-Ilies, Gabriela, Saavedra, Harold I.
Publicado 2015

98729 Professional Development Core of the Hispanic Alliance for Clinical and Translational Research: a scientific productivity catalyst for underrepresented minorities (URM) in Cl...

por Torres-Cintrón, Mariela, Irizarry-Ramírez, Margarita, Saavedra, Harold
Publicado 2021

The G(1 )phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification

por Harrison, Mary K, Adon, Arsene M, Saavedra, Harold I
Publicado 2011

Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity

por Jusino, Shirley, Fernández-Padín, Fabiola M., Saavedra, Harold I.
Publicado 2018

The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1

por Lee, Miyoung, Rivera-Rivera, Yainyrette, Moreno, Carlos S., Saavedra, Harold I.
Publicado 2017

Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells

por Lee, Mi-Young, Marina, Mihaela, King, Jamie L, Saavedra, Harold I
Publicado 2014

Poldip2 Knockout Results in Perinatal Lethality, Reduced Cellular Growth and Increased Autophagy of Mouse Embryonic Fibroblasts

por Brown, David I., Lassègue, Bernard, Lee, Minyoung, Zafari, Rostam, Long, James S., Saavedra, Harold I., Griendling, Kathy K.
Publicado 2014

TTK promotes mesenchymal signaling via multiple mechanisms in triple negative breast cancer

por King, Jamie L., Zhang, Baotong, Li, Yixiang, Li, Kathy P., Ni, Jianping J., Saavedra, Harold I., Dong, Jin-Tang
Publicado 2018

Sustained Shugoshin 1 downregulation reduces tumor growth and metastasis in a mouse xenograft tumor model of triple-negative breast cancer

por Jusino, Shirley, Rivera-Rivera, Yainyrette, Chardón-Colón, Camille, Rodríguez-Rodríguez, Patricia C., Román-González, Janeishly, Juliá-Hernández, Valeria S., Isidro, Angel, Mo, Qianxing, Saavedra, Harold I.
Publicado 2023

The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells

por Rivera-Rivera, Yainyrette, Marina, Mihaela, Jusino, Shirley, Lee, Miyoung, Velázquez, Jaleisha Vélez, Chardón-Colón, Camille, Vargas, Geraldine, Padmanabhan, Jaya, Chellappan, Srikumar P., Saavedra, Harold I.
Publicado 2021

Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis

por Hagen, Katie R, Zeng, Xiangbin, Lee, Mi-Young, Tucker Kahn, Shannon, Harrison Pitner, Mary Kathryn, Zaky, Sandra S, Liu, Yuan, O’Regan, Ruth M, Deng, Xingming, Saavedra, Harold I
Publicado 2013

Ethnic and racial-specific differences in levels of centrosome-associated mitotic kinases, proliferative and epithelial-to-mesenchymal markers in breast cancers

por Rivera-Rivera, Yainyrette, Vargas, Geraldine, Jaiswal, Neha, Núñez-Marrero, Angel, Li, Jiannong, Chen, Dung-Tsa, Eschrich, Steven, Rosa, Marilin, Johnson, Joseph O., Dutil, Julie, Chellappan, Srikumar P., Saavedra, Harold I.
Publicado 2022