Nitric oxide released from JS-K induces cell death by mitotic catastrophe as part of necrosis in glioblastoma multiforme

por Günzle, Jessica, Osterberg, Nadja, Saavedra, Joseph E, Weyerbrock, Astrid
Publicado 2016

Direct Reaction of Amides with Nitric Oxide To Form Diazeniumdiolates

por Holland, Ryan J., Klose, John R., Deschamps, Jeffrey R., Cao, Zhao, Keefer, Larry K., Saavedra, Joseph E.
Publicado 2014

Aminolysis of an N-Diazeniumdiolated Amidine as an Approach to Diazeniumdiolated Ammonia

por Biswas, Debanjan, Hrabie, Joseph A., Saavedra, Joseph E., Cao, Zhao, Keefer, Larry K., Ivanic, Joseph, Holland, Ryan J.
Publicado 2014

TIMP-2 mediates the anti-invasive effects of the nitric oxide-releasing prodrug JS-K in breast cancer cells

por Simeone, Ann-Marie, McMurtry, Vanity, Nieves-Alicea, René, Saavedra, Joseph E, Keefer, Larry K, Johnson, Marcella M, Tari, Ana M
Publicado 2008

Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance()

por Maciag, Anna E., Holland, Ryan J., Robert Cheng, Y.-S., Rodriguez, Luis G., Saavedra, Joseph E., Anderson, Lucy M., Keefer, Larry K.
Publicado 2013

ATF3 reduces migration capacity by regulation of matrix metalloproteinases via NFκB and STAT3 inhibition in glioblastoma

por Guenzle, Jessica, Wolf, Louisa J, Garrelfs, Nicklas W C, Goeldner, Jonathan M, Osterberg, Nadja, Schindler, Cora R, Saavedra, Joseph E, Weyerbrock, Astrid
Publicado 2017

Structure-based design of anticancer prodrug PABA/NO

por Ji, Xinhua, Pal, Ajai, Kalathur, Ravi, Hu, Xun, Gu, Yijun, Saavedra, Joseph E, Buzard, Gregory S, Srinivasan, Aloka, Keefer, Larry K, Singh, Shivendra V
Publicado 2009

Dual Mechanisms of HNO Generation by a Nitroxyl Prodrug of the Diazeniumdiolate (NONOate) Class

por Andrei, Daniela, Salmon, Debra J., Donzelli, Sonia, Wahab, Azadeh, Klose, John R., Citro, Michael L., Saavedra, Joseph E., Wink, David A., Miranda, Katrina M., Keefer, Larry K.
Publicado 2010

Nitric Oxide (NO) Releasing Poly ADP-ribose Polymerase 1 (PARP-1) Inhibitors Targeted to Glutathione S-Transferase P1-Overexpressing Cancer Cells

por Maciag, Anna E., Holland, Ryan J., Kim, Youseung, Kumari, Vandana, Luthers, Christina E., Sehareen, Waheed S., Biswas, Debanjan, Morris, Nicole L., Ji, Xinhua, Anderson, Lucy M., Saavedra, Joseph E., Keefer, Larry K.
Publicado 2014

Hydrolytic Reactivity Trends among Potential Prodrugs of the O(2)-Glycosylated Diazeniumdiolate Family. Targeting Nitric Oxide to Macrophages for Antileishmanial Activity

por Valdez, Carlos A., Saavedra, Joseph E., Showalter, Brett M., Davies, Keith M., Wilde, Thomas C., Citro, Michael L., Barchi, Joseph J., Deschamps, Jeffrey R., Parrish, Damon, El-Gayar, Stefan, Schleicher, Ulrike, Bogdan, Christian, Keefer, Larry K.
Publicado 2008