The Average Body Surface Area of Adult Cancer Patients in the UK: A Multicentre Retrospective Study

por Sacco, Joseph J., Botten, Joanne, Macbeth, Fergus, Bagust, Adrian, Clark, Peter
Publicado 2010

The Chick Embryo Xenograft Model for Malignant Pleural Mesothelioma: A Cost and Time Efficient 3Rs Model for Drug Target Evaluation

por Barnett, Sarah E., Herrmann, Anne, Shaw, Liam, Gash, Elisabeth N., Poptani, Harish, Sacco, Joseph J., Coulson, Judy M.
Publicado 2022

Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development

por Figueiredo, Carlos R, Kalirai, Helen, Sacco, Joseph J, Azevedo, Ricardo A, Duckworth, Andrew, Slupsky, Joseph R, Coulson, Judy M, Coupland, Sarah E
Publicado 2020

The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity

por Fielding, Andrew B., Concannon, Matthew, Darling, Sarah, Rusilowicz-Jones, Emma V., Sacco, Joseph J., Prior, Ian A., Clague, Michael J., Urbé, Sylvie, Coulson, Judy M.
Publicado 2018

Talimogene laherparepvec upregulates immune-cell populations in non-injected lesions: findings from a phase II, multicenter, open-label study in patients with stage IIIB–IVM1c mela...

por Malvehy, Josep, Samoylenko, Igor, Schadendorf, Dirk, Gutzmer, Ralf, Grob, Jean-Jacques, Sacco, Joseph J, Gorski, Kevin S, Anderson, Abraham, Pickett, Cheryl A, Liu, Kate, Gogas, Helen
Publicado 2021

Sensitivity and Specificity of Different Prognostic Systems in Guiding Surveillance for Metastases in Uveal Melanoma

por Robinson, Helena, Eleuteri, Antonio, Sacco, Joseph J., Hussain, Rumana, Heimann, Heinrich, Taktak, Azzam F. G., Damato, Bertil, Thompson, Alexander J., Allen, Thomas, Kalirai, Helen, Coupland, Sarah E.
Publicado 2023

Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors

por Sacco, Joseph J., Kenyani, Jenna, Butt, Zohra, Carter, Rachel, Chew, Hui Yi, Cheeseman, Liam P., Darling, Sarah, Denny, Michael, Urbé, Sylvie, Clague, Michael J., Coulson, Judy M.
Publicado 2015

Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma

por Farquhar, Neil, Thornton, Sophie, Coupland, Sarah E, Coulson, Judy M, Sacco, Joseph J, Krishna, Yamini, Heimann, Heinrich, Taktak, Azzam, Cebulla, Colleen M, Abdel‐Rahman, Mohamed H, Kalirai, Helen
Publicado 2017

Phase I Study of Safety, Tolerability, and Efficacy of Tebentafusp Using a Step-Up Dosing Regimen and Expansion in Patients With Metastatic Uveal Melanoma

por Carvajal, Richard D., Nathan, Paul, Sacco, Joseph J., Orloff, Marlana, Hernandez-Aya, Leonel F., Yang, Jessica, Luke, Jason J., Butler, Marcus O., Stanhope, Sarah, Collins, Laura, McAlpine, Cheryl, Holland, Chris, Abdullah, Shaad E., Sato, Takami
Publicado 2022

Gene expression profiling in bladder cancer identifies potential therapeutic targets

por Hussain, Syed A., Palmer, Daniel H., Syn, Wing-Kin, Sacco, Joseph J., Greensmith, Richard M.D., Elmetwali, Taha, Aachi, Vijay, Lloyd, Bryony H., Jithesh, Puthen V., Arrand, John, Barton, Darren, Ansari, Jawaher, Sibson, D. Ross, James, Nicholas D.
Publicado 2017

BAP1 Loss Is Associated with Higher ASS1 Expression in Epithelioid Mesothelioma: Implications for Therapeutic Stratification

por Barnett, Sarah E., Kenyani, Jenna, Tripari, Martina, Butt, Zohra, Grosman, Rudi, Querques, Francesca, Shaw, Liam, Silva, Luisa C., Goate, Zoe, Marciniak, Stefan J., Rassl, Doris M., Jackson, Richard, Lian, Lu-Yun, Szlosarek, Peter W., Sacco, Joseph J., Coulson, Judy M.
Publicado 2023

Su1185 IMMUNE CHECKPOINT INHIBITOR-RELATED COLITIS ASSESSMENT AND PROGNOSIS: CAN UCEIS, MAYO AND NANCY INDEX SCORING POINT THE WAY?

por Cheung, Vincent T., Gupta, Tarun, Olsson-Brown, Anna C., Subramanian, Sreedhar, Sasson, Sarah C., Heseltine, Jonathan, Fryer, Eve, Collantes-Bellido, Elena, Sacco, Joseph J., Pirmohamed, Munir, Simmons, Alison, Klenerman, Paul, Fairfax, Benjamin P., Payne, Miranda J., Middleton, Mark R., Brain, Oliver
Publicado 2020

Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck

por Carter, Rachel J., Milani, Mateus, Butterworth, Michael, Alotibi, Ahoud, Harper, Nicholas, Yedida, Govindaraju, Greaves, Georgia, Al-Zebeeby, Aoula, Jorgensen, Andrea L., Schache, Andrew G., Risk, Janet M., Shaw, Richard J., Jones, Terry M., Sacco, Joseph J., Hurlstone, Adam, Cohen, Gerald M., Varadarajan, Shankar
Publicado 2019

Checkpoint-blocker-induced autoimmunity is associated with favourable outcome in metastatic melanoma and distinct T-cell expression profiles

por Ye, Weiyu, Olsson-Brown, Anna, Watson, Robert A., Cheung, Vincent T. F., Morgan, Robert D., Nassiri, Isar, Cooper, Rosalin, Taylor, Chelsea A., Akbani, Umair, Brain, Oliver, Matin, Rubeta N., Coupe, Nicholas, Middleton, Mark R., Coles, Mark, Sacco, Joseph J., Payne, Miranda J., Fairfax, Benjamin P.
Publicado 2021

Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?

por Cheung, Vincent Ting Fung, Gupta, Tarun, Olsson-Brown, Anna, Subramanian, Sreedhar, Sasson, Sarah Christina, Heseltine, Jonathan, Fryer, Eve, Collantes, Elena, Sacco, Joseph J., Pirmohamed, Munir, Simmons, Alison, Klenerman, Paul, Tuthill, Mark, Protheroe, Andrew S., Chitnis, Meenali, Fairfax, Benjamin Peter, Payne, Miranda Jane, Middleton, Mark Ross, Brain, Oliver
Publicado 2020

Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features, and clinical outcome

por Kenawy, Nihal, Kalirai, Helen, Sacco, Joseph J., Lake, Sarah L., Heegaard, Steffen, Larsen, Ann‐Cathrine, Finger, Paul T., Milman, Tatyana, Chin, Kimberly, Mosci, Carlo, Lanza, Francesco, Moulin, Alexandre, Schmitt, Caroline A., Caujolle, Jean Pierre, Maschi, Célia, Marinkovic, Marina, Taktak, Azzam F., Heimann, Heinrich, Damato, Bertil E., Coupland, Sarah E.
Publicado 2019

Clinical and molecular response to tebentafusp in previously treated patients with metastatic uveal melanoma: a phase 2 trial

por Carvajal, Richard D., Butler, Marcus O., Shoushtari, Alexander N., Hassel, Jessica C., Ikeguchi, Alexandra, Hernandez-Aya, Leonel, Nathan, Paul, Hamid, Omid, Piulats, Josep M., Rioth, Matthew, Johnson, Douglas B., Luke, Jason J., Espinosa, Enrique, Leyvraz, Serge, Collins, Laura, Goodall, Howard M., Ranade, Koustubh, Holland, Chris, Abdullah, Shaad E., Sacco, Joseph J., Sato, Takami
Publicado 2022

Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma

por Visconti, Alessia, Rossi, Niccolò, Deriš, Helena, Lee, Karla A, Hanić, Maja, Trbojević-Akmačić, Irena, Thomas, Andrew M., Bolte, Laura A., Björk, Johannes R., Hooiveld-Noeken, Jahlisa S., Board, Ruth, Harland, Mark, Newton-Bishop, Julia, Harries, Mark, Sacco, Joseph J., Lorigan, Paul, Shaw, Heather M., de Vries, Elisabeth G.E., Fehrmann, Rudolf S.N., Weersma, Rinse K., Spector, Tim D., Nathan, Paul, Hospers, Geke A. P., Sasieni, Peter, Bataille, Veronique, Lauc, Gordan, Falchi, Mario
Publicado 2023

Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs

por Eschweiler, Simon, Ramírez-Suástegui, Ciro, Li, Yingcong, King, Emma, Chudley, Lindsey, Thomas, Jaya, Wood, Oliver, von Witzleben, Adrian, Jeffrey, Danielle, McCann, Katy, Simon, Hayley, Mondal, Monalisa, Wang, Alice, Dicker, Martina, Lopez-Guadamillas, Elena, Chou, Ting-Fang, Dobbs, Nicola A., Essame, Louisa, Acton, Gary, Kelly, Fiona, Halbert, Gavin, Sacco, Joseph J., Schache, Andrew Graeme, Shaw, Richard, McCaul, James Anthony, Paterson, Claire, Davies, Joseph H., Brennan, Peter A., Singh, Rabindra P., Loadman, Paul M., Wilson, William, Hackshaw, Allan, Seumois, Gregory, Okkenhaug, Klaus, Thomas, Gareth J., Jones, Terry M., Ay, Ferhat, Friberg, Greg, Kronenberg, Mitchell, Vanhaesebroeck, Bart, Vijayanand, Pandurangan, Ottensmeier, Christian H.
Publicado 2022