The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition

por Sacco, Michael Dominic, Hu, Yanmei, Gongora, Maura Verenice, Meilleur, Flora, Kemp, Michael Trent, Zhang, Xiujun, Wang, Jun, Chen, Yu
Publicado 2022

GpsB Coordinates Cell Division and Cell Surface Decoration by Wall Teichoic Acids in Staphylococcus aureus

por Hammond, Lauren R., Sacco, Michael D., Khan, Sebastian J., Spanoudis, Catherine, Hough-Neidig, Abigail, Chen, Yu, Eswara, Prahathees J.
Publicado 2022

Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir

por Xia, Zilei, Sacco, Michael, Hu, Yanmei, Ma, Chunlong, Meng, Xiangzhi, Zhang, Fushun, Szeto, Tommy, Xiang, Yan, Chen, Yu, Wang, Jun
Publicado 2021

Interdependent YpsA- and YfhS-Mediated Cell Division and Cell Size Phenotypes in Bacillus subtilis

por Brzozowski, Robert S., Tomlinson, Brooke R., Sacco, Michael D., Chen, Judy J., Ali, Anika N., Chen, Yu, Shaw, Lindsey N., Eswara, Prahathees J.
Publicado 2020

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

por Ma, Chunlong, Sacco, Michael D., Hurst, Brett, Townsend, Julia A., Hu, Yanmei, Szeto, Tommy, Zhang, Xiujun, Tarbet, Bart, Marty, Michael T., Chen, Yu, Wang, Jun
Publicado 2020

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

por Ma, Chunlong, Sacco, Michael Dominic, Hurst, Brett, Townsend, Julia Alma, Hu, Yanmei, Szeto, Tommy, Zhang, Xiujun, Tarbet, Bart, Marty, Michael Thomas, Chen, Yu, Wang, Jun
Publicado 2020

Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography

por Kroeck, Kyle G., Sacco, Michael D., Smith, Emmanuel W., Zhang, Xiujun, Shoun, Daniel, Akhtar, Afroza, Darch, Sophie E., Cohen, Frederick, Andrews, Logan D., Knox, John E., Chen, Yu
Publicado 2019

Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay

por Xia, Zilei, Sacco, Michael Dominic, Ma, Chunlong, Townsend, Julia Alma, Kitamura, Naoya, Hu, Yanmei, Ba, Mandy, Szeto, Tommy, Zhang, Xiujun, Meng, Xiangzhi, Zhang, Fushun, Xiang, Yan, Marty, Michael Thomas, Chen, Yu, Wang, Jun
Publicado 2021

Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L

por Sacco, Michael Dominic, Ma, Chunlong, Lagarias, Panagiotis, Gao, Ang, Townsend, Julia Alma, Meng, Xiangzhi, Dube, Peter, Zhang, Xiujun, Hu, Yanmei, Kitamura, Naoya, Hurst, Brett, Tarbet, Bart, Marty, Michael Thomas, Kolocouris, Antonios, Xiang, Yan, Chen, Yu, Wang, Jun
Publicado 2020

Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M(pro) and cathepsin L

por Sacco, Michael Dominic, Ma, Chunlong, Lagarias, Panagiotis, Gao, Ang, Townsend, Julia Alma, Meng, Xiangzhi, Dube, Peter, Zhang, Xiujun, Hu, Yanmei, Kitamura, Naoya, Hurst, Brett, Tarbet, Bart, Marty, Michael Thomas, Kolocouris, Antonios, Xiang, Yan, Chen, Yu, Wang, Jun
Publicado 2020

Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay

por Ma, Chunlong, Sacco, Michael Dominic, Xia, Zilei, Lambrinidis, George, Townsend, Julia Alma, Hu, Yanmei, Meng, Xiangzhi, Szeto, Tommy, Ba, Mandy, Zhang, Xiujun, Gongora, Maura, Zhang, Fushun, Marty, Michael Thomas, Xiang, Yan, Kolocouris, Antonios, Chen, Yu, Wang, Jun
Publicado 2021

A unique class of Zn(2+)-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

por Sacco, Michael D., Wang, Shaohui, Adapa, Swamy R., Zhang, Xiujun, Lewandowski, Eric M., Gongora, Maura V., Keramisanou, Dimitra, Atlas, Zachary D., Townsend, Julia A., Gatdula, Jean R., Morgan, Ryan T., Hammond, Lauren R., Marty, Michael T., Wang, Jun, Eswara, Prahathees J., Gelis, Ioannis, Jiang, Rays H. Y., Sun, Xingmin, Chen, Yu
Publicado 2022

Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β-Lactamases

por Durand-Réville, Thomas F., Comita-Prevoir, Janelle, Zhang, Jing, Wu, Xiaoyun, May-Dracka, Tricia L., Romero, Jan Antoinette C., Wu, Frank, Chen, April, Shapiro, Adam B., Carter, Nicole M., McLeod, Sarah M., Giacobbe, Robert A., Verheijen, Jeroen C., Lahiri, Sushmita D., Sacco, Michael D., Chen, Yu, O’Donnell, John P., Miller, Alita A., Mueller, John P., Tommasi, Rubén A.
Publicado 2020