Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation

por Gopal, Keshav, Karwi, Qutuba G., Tabatabaei Dakhili, Seyed Amirhossein, Wagg, Cory S., Zhang, Liyan, Sun, Qiuyu, Saed, Christina T., Panidarapu, Sai, Perfetti, Riccardo, Ramasamy, Ravichandran, Ussher, John R., Lopaschuk, Gary D.
Publicado 2023

Stimulating myocardial pyruvate dehydrogenase activity fails to alleviate cardiac abnormalities in a mouse model of human Barth syndrome

por Greenwell, Amanda A., Tabatabaei Dakhili, Seyed Amirhossein, Gopal, Keshav, Saed, Christina T., Chan, Jordan S. F., Kazungu Mugabo, Nick, Zhabyeyev, Pavel, Eaton, Farah, Kruger, Jennifer, Oudit, Gavin Y., Ussher, John R.
Publicado 2022

Loss of muscle PDH induces lactic acidosis and adaptive anaplerotic compensation via pyruvate-alanine cycling and glutaminolysis

por Gopal, Keshav, Abdualkader, Abdualrahman Mohammed, Li, Xiaobei, Greenwell, Amanda A., Karwi, Qutuba G., Altamimi, Tariq R., Saed, Christina, Uddin, Golam M., Darwesh, Ahmed M., Jamieson, K. Lockhart, Kim, Ryekjang, Eaton, Farah, Seubert, John M., Lopaschuk, Gary D., Ussher, John R., Al Batran, Rami
Publicado 2023