Neutrophil extracellular traps: from antimicrobial innate immunity to the development of chemotherapy-induced peripheral neuropathy

por Koike, Haruki, Iguchi, Yohei, Sahashi, Kentaro, Katsuno, Masahisa
Publicado 2023

Preclinical progression of neurodegenerative diseases

por Katsuno, Masahisa, Sahashi, Kentaro, Iguchi, Yohei, Hashizume, Atsushi
Publicado 2018

Significance of Oligomeric and Fibrillar Species in Amyloidosis: Insights into Pathophysiology and Treatment

por Koike, Haruki, Iguchi, Yohei, Sahashi, Kentaro, Katsuno, Masahisa
Publicado 2021

Nucleic Acid-Based Therapeutic Approach for Spinal and Bulbar Muscular Atrophy and Related Neurological Disorders

por Hirunagi, Tomoki, Sahashi, Kentaro, Meilleur, Katherine G., Katsuno, Masahisa
Publicado 2022

Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy

por Ogura, Yosuke, Sahashi, Kentaro, Hirunagi, Tomoki, Iida, Madoka, Miyata, Takaki, Katsuno, Masahisa
Publicado 2022

Motor neuron cell-nonautonomous rescue of spinal muscular atrophy phenotypes in mild and severe transgenic mouse models

por Hua, Yimin, Liu, Ying Hsiu, Sahashi, Kentaro, Rigo, Frank, Bennett, C. Frank, Krainer, Adrian R.
Publicado 2015

The Japan Registry for Adult Subjects of Spinal Muscular Atrophy (jREACT-SMA): Protocol for a Longitudinal Observational Study

por Sahashi, Kentaro, Hashizume, Atsushi, Kuwatsuka, Yachiyo, Chinen, Madoka, Saotome-Nakamura, Ai, Ando, Masahiko, Katsuno, Masahisa
Publicado 2022

Peripheral SMN restoration is essential for long-term rescue of a severe SMA mouse model

por Hua, Yimin, Sahashi, Kentaro, Rigo, Frank, Hung, Gene, Horev, Guy, Bennett, C. Frank, Krainer, Adrian R.
Publicado 2011

In vitro and in silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5′ splice sites

por Sahashi, Kentaro, Masuda, Akio, Matsuura, Tohru, Shinmi, Jun, Zhang, Zhujun, Takeshima, Yasuhiro, Matsuo, Masafumi, Sobue, Gen, Ohno, Kinji
Publicado 2007

Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice

por Sinha, Rahul, Kim, Young Jin, Nomakuchi, Tomoki, Sahashi, Kentaro, Hua, Yimin, Rigo, Frank, Bennett, C Frank, Krainer, Adrian R
Publicado 2018

DNA methylation inhibitor attenuates polyglutamine‐induced neurodegeneration by regulating Hes5

por Kondo, Naohide, Tohnai, Genki, Sahashi, Kentaro, Iida, Madoka, Kataoka, Mayumi, Nakatsuji, Hideaki, Tsutsumi, Yutaka, Hashizume, Atsushi, Adachi, Hiroaki, Koike, Haruki, Shinjo, Keiko, Kondo, Yutaka, Sobue, Gen, Katsuno, Masahisa
Publicado 2019

Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS

por Hirunagi, Tomoki, Sahashi, Kentaro, Tachikawa, Kiyoshi, Leu, Angel I., Nguyen, Michelle, Mukthavaram, Rajesh, Karmali, Priya P., Chivukula, Padmanabh, Tohnai, Genki, Iida, Madoka, Onodera, Kazunari, Ohyama, Manabu, Okada, Yohei, Okano, Hideyuki, Katsuno, Masahisa
Publicado 2021

Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice

por Takeuchi, Toshihide, Maeta, Kazuhiro, Ding, Xin, Oe, Yukako, Takeda, Akiko, Inoue, Mana, Nagano, Seiichi, Fujihara, Tsuyoshi, Matsuda, Seiji, Ishigaki, Shinsuke, Sahashi, Kentaro, Minakawa, Eiko N., Mochizuki, Hideki, Neya, Masahiro, Sobue, Gen, Nagai, Yoshitaka
Publicado 2023

Pathological impact of SMN2 mis-splicing in adult SMA mice

por Sahashi, Kentaro, Ling, Karen K Y, Hua, Yimin, Wilkinson, John Erby, Nomakuchi, Tomoki, Rigo, Frank, Hung, Gene, Xu, David, Jiang, Ya-Ping, Lin, Richard Z, Ko, Chien-Ping, Bennett, C Frank, Krainer, Adrian R
Publicado 2013

Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy

por Iida, Madoka, Sahashi, Kentaro, Kondo, Naohide, Nakatsuji, Hideaki, Tohnai, Genki, Tsutsumi, Yutaka, Noda, Seiya, Murakami, Ayuka, Onodera, Kazunari, Okada, Yohei, Nakatochi, Masahiro, Tsukagoshi Okabe, Yuka, Shimizu, Shinobu, Mizuno, Masaaki, Adachi, Hiroaki, Okano, Hideyuki, Sobue, Gen, Katsuno, Masahisa
Publicado 2019

The SYNGAP1 3′UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK

por Yokoi, Satoshi, Ito, Takuji, Sahashi, Kentaro, Nakatochi, Masahiro, Nakamura, Ryoichi, Tohnai, Genki, Fujioka, Yusuke, Ishigaki, Shinsuke, Udagawa, Tsuyoshi, Izumi, Yuishin, Morita, Mitsuya, Kano, Osamu, Oda, Masaya, Sone, Takefumi, Okano, Hideyuki, Atsuta, Naoki, Katsuno, Masahisa, Okada, Yohei, Sobue, Gen
Publicado 2022

Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology

por Tsujikawa, Koyo, Hamanaka, Kohei, Riku, Yuichi, Hattori, Yuki, Hara, Norikazu, Iguchi, Yohei, Ishigaki, Shinsuke, Hashizume, Atsushi, Miyatake, Satoko, Mitsuhashi, Satomi, Miyazaki, Yu, Kataoka, Mayumi, Jiayi, Li, Yasui, Keizo, Kuru, Satoshi, Koike, Haruki, Kobayashi, Kenta, Sahara, Naruhiko, Ozaki, Norio, Yoshida, Mari, Kakita, Akiyoshi, Saito, Yuko, Iwasaki, Yasushi, Miyashita, Akinori, Iwatsubo, Takeshi, Ikeuchi, Takeshi, Miyata, Takaki, Sobue, Gen, Matsumoto, Naomichi, Sahashi, Kentaro, Katsuno, Masahisa
Publicado 2022