Long non-coding RNA HIF1A-As2 and MYC form a double-positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung cancer

por Yang, Kaixin, Zhang, Wenyang, Zhong, Linghui, Xiao, Yinan, Sahoo, Sudhakar, Fassan, Matteo, Zeng, Kang, Magee, Peter, Garofalo, Michela, Shi, Lei
Publicado 2023

Hypoxia Is Associated with Increased Immune Infiltrates and Both Anti-Tumour and Immune Suppressive Signalling in Muscle-Invasive Bladder Cancer

por Smith, Vicky, Lee, Dave, Reardon, Mark, Shabbir, Rekaya, Sahoo, Sudhakar, Hoskin, Peter, Choudhury, Ananya, Illidge, Timothy, West, Catharine M. L.
Publicado 2023

PDGFR-modulated miR-23b cluster and miR-125a-5p suppress lung tumorigenesis by targeting multiple components of KRAS and NF-kB pathways

por Naidu, Srivatsava, Shi, Lei, Magee, Peter, Middleton, Justin D., Laganá, Alessandro, Sahoo, Sudhakar, Leong, Hui Sun, Galvin, Melanie, Frese, Kristopher, Dive, Caroline, Guzzardo, Vincenza, Fassan, Matteo, Garofalo, Michela
Publicado 2017

KRAS induces lung tumorigenesis through microRNAs modulation

por Shi, Lei, Middleton, Justin, Jeon, Young-Jun, Magee, Peter, Veneziano, Dario, Laganà, Alessandro, Leong, Hui-Sun, Sahoo, Sudhakar, Fassan, Matteo, Booton, Richard, Shah, Rajesh, Crosbie, Philip A. J., Garofalo, Michela
Publicado 2018

Vulnerability of drug‐resistant EML4‐ALK rearranged lung cancer to transcriptional inhibition

por Paliouras, Athanasios R, Buzzetti, Marta, Shi, Lei, Donaldson, Ian J, Magee, Peter, Sahoo, Sudhakar, Leong, Hui‐Sun, Fassan, Matteo, Carter, Matthew, Di Leva, Gianpiero, Krebs, Matthew G, Blackhall, Fiona, Lovly, Christine M, Garofalo, Michela
Publicado 2020

Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown p...

por Torres-Ayuso, Pedro, Sahoo, Sudhakar, Ashton, Garry, An, Elvira, Simms, Nicole, Galvin, Melanie, Leong, Hui Sun, Frese, Kristopher K, Simpson, Kathryn, Cook, Natalie, Hughes, Andrew, Miller, Crispin J, Marais, Richard, Dive, Caroline, Krebs, Matthew G, Brognard, John
Publicado 2018

Analysis of circulating cell-free DNA identifies KRAS copy number gain and mutation as a novel prognostic marker in Pancreatic cancer

por Mohan, Sumitra, Ayub, Mahmood, Rothwell, Dominic G., Gulati, Sakshi, Kilerci, Bedirhan, Hollebecque, Antoine, Sun Leong, Hui, Smith, Nigel K., Sahoo, Sudhakar, Descamps, Tine, Zhou, Cong, Hubner, Richard A., McNamara, Mairéad G., Lamarca, Angela, Valle, Juan W., Dive, Caroline, Brady, Ged
Publicado 2019

Profiling of Circulating Free DNA Using Targeted and Genome-wide Sequencing in Patients with SCLC

por Mohan, Sumitra, Foy, Victoria, Ayub, Mahmood, Leong, Hui Sun, Schofield, Pieta, Sahoo, Sudhakar, Descamps, Tine, Kilerci, Bedirhan, Smith, Nigel K., Carter, Mathew, Priest, Lynsey, Zhou, Cong, Carr, T. Hedley, Miller, Crispin, Faivre-Finn, Corinne, Blackhall, Fiona, Rothwell, Dominic G., Dive, Caroline, Brady, Gerard
Publicado 2020

A KRAS-responsive long non-coding RNA controls microRNA processing

por Shi, Lei, Magee, Peter, Fassan, Matteo, Sahoo, Sudhakar, Leong, Hui Sun, Lee, Dave, Sellers, Robert, Brullé-Soumaré, Laura, Cairo, Stefano, Monteverde, Tiziana, Volinia, Stefano, Smith, Duncan D., Di Leva, Gianpiero, Galuppini, Francesca, Paliouras, Athanasios R., Zeng, Kang, O’Keefe, Raymond, Garofalo, Michela
Publicado 2021

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

por Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.
Publicado 2018

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade

por Bonavita, Eduardo, Bromley, Christian P., Jonsson, Gustav, Pelly, Victoria S., Sahoo, Sudhakar, Walwyn-Brown, Katherine, Mensurado, Sofia, Moeini, Agrin, Flanagan, Eimear, Bell, Charlotte R., Chiang, Shih-Chieh, Chikkanna-Gowda, C.P., Rogers, Neil, Silva-Santos, Bruno, Jaillon, Sebastien, Mantovani, Alberto, Reis e Sousa, Caetano, Guerra, Nadia, Davis, Daniel M., Zelenay, Santiago
Publicado 2020