Asymmetric synthesis of host-directed inhibitors of myxoviruses

por Moore, Terry W, Sana, Kasinath, Yan, Dan, Thepchatri, Pahk, Ndungu, John M, Saindane, Manohar T, Lockwood, Mark A, Natchus, Michael G, Liotta, Dennis C, Plemper, Richard K, Snyder, James P, Sun, Aiming
Publicado 2013

ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens

por Squires, Katherine E., Mayers, Douglas L., Bluemling, Gregory R., Kolykhalov, Alexander A., Guthrie, David B., Reddy, Prabhakar, Mitchell, Debbie G., Saindane, Manohar T., Sticher, Zachary M., Edpuganti, Vindhya, De La Rosa, Abel
Publicado 2020

SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

por Lieber, Carolin M., Cox, Robert M., Sourimant, Julien, Wolf, Josef D., Juergens, Kate, Phung, Quynh, Saindane, Manohar T., Smith, Meghan K., Sticher, Zachary M., Kalykhalov, Alexander A., Natchus, Michael G., Painter, George R., Sakamoto, Kaori, Greninger, Alexander L., Plemper, Richard K.
Publicado 2022

Small-Molecule Antiviral β-d-N(4)-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

por Agostini, Maria L., Pruijssers, Andrea J., Chappell, James D., Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L., Bluemling, Gregory R., Lockwood, Mark A., Sheahan, Timothy P., Sims, Amy C., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George R., Baric, Ralph S., Denison, Mark R.
Publicado 2019

4’-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

por Lieber, Carolin M., Aggarwal, Megha, Yoon, Jeong-Joong, Cox, Robert M., Kang, Hae-Ji, Sourimant, Julien, Toots, Mart, Johnson, Scott K., Jones, Cheryl A., Sticher, Zachary M., Kolykhalov, Alexander A., Saindane, Manohar T., Tompkins, Stephen M., Planz, Oliver, Painter, George R., Natchus, Michael G., Sakamoto, Kaori, Plemper, Richard K.
Publicado 2023

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

por Sheahan, Timothy P., Sims, Amy C., Zhou, Shuntai, Graham, Rachel L., Pruijssers, Andrea J., Agostini, Maria L., Leist, Sarah R., Schäfer, Alexandra, Dinnon, Kenneth H., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., George, Amelia S., Hill, Collin S., Montgomery, Stephanie A., Brown, Ariane J., Bluemling, Gregory R., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George, Harcourt, Jennifer, Tamin, Azaibi, Thornburg, Natalie J., Swanstrom, Ronald, Denison, Mark R., Baric, Ralph S.
Publicado 2020