Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS Cells

por Saito, Megumu K.
Publicado 2021

Induced pluripotent stem cells representing Nakajo-Nishimura syndrome

por Kanazawa, Nobuo, Honda-Ozaki, Fumiko, Saito, Megumu K.
Publicado 2019

Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition

por Kirino, Kosuke, Nakahata, Tatsutoshi, Taguchi, Tomoaki, Saito, Megumu K.
Publicado 2018

A concise in vitro model for evaluating interactions between macrophage and skeletal muscle cells during muscle regeneration

por Kase, Naoya, Kitagawa, Yohko, Ikenaka, Akihiro, Niwa, Akira, Saito, Megumu K.
Publicado 2023

ZEB2 and MEIS1 independently contribute to hematopoiesis via early hematopoietic enhancer activation

por Kitagawa, Yohko, Ikenaka, Akihiro, Sugimura, Ryohichi, Niwa, Akira, Saito, Megumu K.
Publicado 2023

Tofacitinib, a suppressor of NOD2 expression, is a potential treatment for Blau syndrome

por Ueki, Yoko, Takimoto-Ito, Riko, Saito, Megumu K., Tanizaki, Hideaki, Kambe, Naotomo
Publicado 2023

Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity

por Seki, Ryosuke, Ohta, Akira, Niwa, Akira, Sugimine, Yoshinori, Naito, Haruna, Nakahata, Tatsutoshi, Saito, Megumu K.
Publicado 2020

Correction: Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity

por Seki, Ryosuke, Ohta, Akira, Niwa, Akira, Sugimine, Yoshinori, Naito, Haruna, Nakahata, Tatsutoshi, Saito, Megumu K.
Publicado 2021

Induced Pluripotent Stem Cell-Derived Monocytes/Macrophages in Autoinflammatory Diseases

por Tanaka, Takayuki, Shiba, Takeshi, Honda, Yoshitaka, Izawa, Kazushi, Yasumi, Takahiro, Saito, Megumu K., Nishikomori, Ryuta
Publicado 2022

Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification

por Matsuo, Shiori, Nishinaka-Arai, Yoko, Kazuki, Yasuhiro, Oshimura, Mitsuo, Nakahata, Tatsutoshi, Niwa, Akira, Saito, Megumu K.
Publicado 2021

SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis

por Ikenaka, Akihiro, Kitagawa, Yohko, Yoshida, Michiko, Lin, Chuang-Yu, Niwa, Akira, Nakahata, Tatsutoshi, Saito, Megumu K
Publicado 2023

Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells

por Ono, Hiroaki, Ohta, Ryo, Kawasaki, Yuri, Niwa, Akira, Takada, Hidetoshi, Nakahata, Tatsutoshi, Ohga, Shouichi, Saito, Megumu K.
Publicado 2018

Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model

por Ichisima, Jose, Suzuki, Naoya M., Samata, Bumpei, Awaya, Tomonari, Takahashi, Jun, Hagiwara, Masatoshi, Nakahata, Tatsutoshi, Saito, Megumu K.
Publicado 2019

Potential Benefits of TNF Targeting Therapy in Blau Syndrome, a NOD2-Associated Systemic Autoinflammatory Granulomatosis

por Matsuda, Tomoko, Kambe, Naotomo, Takimoto-Ito, Riko, Ueki, Yoko, Nakamizo, Satoshi, Saito, Megumu K., Takei, Syuji, Kanazawa, Nobuo
Publicado 2022

A Novel Serum-Free Monolayer Culture for Orderly Hematopoietic Differentiation of Human Pluripotent Cells via Mesodermal Progenitors

por Niwa, Akira, Heike, Toshio, Umeda, Katsutsugu, Oshima, Koichi, Kato, Itaru, Sakai, Hiromi, Suemori, Hirofumi, Nakahata, Tatsutoshi, Saito, Megumu K.
Publicado 2011

Pluripotent stem cell‐based screening identifies CUDC‐907 as an effective compound for restoring the in vitro phenotype of Nakajo‐Nishimura syndrome

por Kase, Naoya, Terashima, Madoka, Ohta, Akira, Niwa, Akira, Honda‐Ozaki, Fumiko, Kawasaki, Yuri, Nakahata, Tatsutoshi, Kanazawa, Nobuo, Saito, Megumu K.
Publicado 2020

A disease-specific iPS cell resource for studying rare and intractable diseases

por Saito, Megumu K., Osawa, Mitsujiro, Tsuchida, Nao, Shiraishi, Kotaro, Niwa, Akira, Woltjen, Knut, Asaka, Isao, Ogata, Katsuhisa, Ito, Suminobu, Kobayashi, Shuzo, Yamanaka, Shinya
Publicado 2023

Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs

por Maekawa, Hirotsugu, Jin, Yonghui, Nishio, Megumi, Kawai, Shunsuke, Nagata, Sanae, Kamakura, Takeshi, Yoshitomi, Hiroyuki, Niwa, Akira, Saito, Megumu K., Matsuda, Shuichi, Toguchida, Junya
Publicado 2022

Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations

por Grajcarek, Janin, Monlong, Jean, Nishinaka-Arai, Yoko, Nakamura, Michiko, Nagai, Miki, Matsuo, Shiori, Lougheed, David, Sakurai, Hidetoshi, Saito, Megumu K., Bourque, Guillaume, Woltjen, Knut
Publicado 2019

N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy 21

por Toshikawa, Hiromitsu, Ikenaka, Akihiro, Li, Li, Nishinaka-Arai, Yoko, Niwa, Akira, Ashida, Akira, Kazuki, Yasuhiro, Nakahata, Tatsutoshi, Tamai, Hiroshi, Russell, David W., Saito, Megumu K.
Publicado 2021