A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics

por Lee, Ho-Joon, Kremer, Daniel M., Sajjakulnukit, Peter, Zhang, Li, Lyssiotis, Costas A.
Publicado 2019

Auditory metabolomics, an approach to identify acute molecular effects of noise trauma

por Ji, Lingchao, Lee, Ho-Joon, Wan, Guoqiang, Wang, Guo-Peng, Zhang, Li, Sajjakulnukit, Peter, Schacht, Jochen, Lyssiotis, Costas A., Corfas, Gabriel
Publicado 2019

Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis

por Wubben, Thomas J., Pawar, Mercy, Weh, Eric, Smith, Andrew, Sajjakulnukit, Peter, Zhang, Li, Dai, Lipeng, Hager, Heather, Pai, Manjunath P., Lyssiotis, Costas A., Besirli, Cagri G.
Publicado 2020

DDRE-28. MECHANISTIC AND THERAPEUTIC LINKS BETWEEN PURINE BIOSYNTHESIS AND DNA DAMAGE IN GLIOBLASTOMA

por Scott, Andrew, Zhou, Weihua, Wilder-Romans, Kari, Feng, Jiane, Wu, Zhe, Andren, Anthony, Zhang, Li, Sajjakulnukit, Peter, Kachman, Maureen, Umemura, Yoshie, Schmitt, Melanie, Qi, Nathan, Lawrence, Theodore, Lyssiotis, Costas, Wahl, Daniel
Publicado 2021

Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF–PI3K pathway

por Boyer, Seth, Lee, Ho-Joon, Steele, Nina, Zhang, Li, Sajjakulnukit, Peter, Andren, Anthony, Ward, Matthew H, Singh, Rima, Basrur, Venkatesha, Zhang, Yaqing, Nesvizhskii, Alexey I, Pasca di Magliano, Marina, Halbrook, Christopher J, Lyssiotis, Costas A
Publicado 2022

De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression

por Tangudu, Naveen Kumar, Buj, Raquel, Wang, Hui, Wang, Jiefei, Cole, Aidan R., Uboveja, Apoorva, Fang, Richard, Amalric, Amandine, Sajjakulnukit, Peter, Lyons, Maureen A., Cooper, Kristine, Hempel, Nadine, Snyder, Nathaniel W., Lyssiotis, Costas A., Chandran, Uma R., Aird, Katherine M.
Publicado 2023

Adaptive rewiring of purine metabolism promotes treatment resistance in H3K27M-mutant diffuse midline glioma

por Peterson, Erik R., Sajjakulnukit, Peter, Scott, Andrew J., Heaslip, Caleb, Andren, Anthony, Wilder-Romans, Kari, Zhou, Weihua, Palavalasa, Sravya, Korimerla, Navyateja, Lin, Angelica, Obrien, Alexandra, Kothari, Ayesha, Zhao, Zitong, Zhang, Li, Morgan, Meredith A., Venneti, Sriram, Koschmann, Carl, Jabado, Nada, Lyssiotis, Costas A., Castro, Maria G., Wahl, Daniel R.
Publicado 2023

Hyaluronic acid fuels pancreatic cancer cell growth

por Kim, Peter K, Halbrook, Christopher J, Kerk, Samuel A, Radyk, Megan, Wisner, Stephanie, Kremer, Daniel M, Sajjakulnukit, Peter, Andren, Anthony, Hou, Sean W, Trivedi, Ayush, Thurston, Galloway, Anand, Abhinav, Yan, Liang, Salamanca-Cardona, Lucia, Welling, Samuel D, Zhang, Li, Pratt, Matthew R, Keshari, Kayvan R, Ying, Haoqiang, Lyssiotis, Costas A
Publicado 2021

Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance

por Nwosu, Zeribe Chike, Piorońska, Weronika, Battello, Nadia, Zimmer, Andreas David, Dewidar, Bedair, Han, Mei, Pereira, Sharon, Blagojevic, Biljana, Castven, Darko, Charlestin, Verodia, Holenya, Pavlo, Lochead, Julia, De La Torre, Carolina, Gretz, Norbert, Sajjakulnukit, Peter, Zhang, Li, Ward, Matthew H., Marquardt, Jens U., di Magliano, Marina Pasca, Lyssiotis, Costas A., Sleeman, Jonathan, Wölfl, Stefan, Ebert, Matthias Philip, Meyer, Christoph, Hofmann, Ute, Dooley, Steven
Publicado 2020

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

por Bian, Yingjie, Li, Wei, Kremer, Daniel M., Sajjakulnukit, Peter, Li, Shasha, Crespo, Joel, Nwosu, Zeribe C., Zhang, Li, Czerwonka, Arkadiusz, Pawłowska, Anna, Xia, Houjun, Li, Jing, Liao, Peng, Yu, Jiali, Vatan, Linda, Szeliga, Wojciech, Wei, Shuang, Grove, Sara, Liu, J. Rebecca, McLean, Karen, Cieslik, Marcin, Chinnaiyan, Arul M., Zgodziński, Witold, Wallner, Grzegorz, Wertel, Iwona, Okła, Karolina, Kryczek, Ilona, Lyssiotis, Costas A., Zou, Weiping
Publicado 2020

DDRE-24. TARGETING PURINE METABOLISM TO OVERCOME GLIOBLASTOMA THERAPY RESISTANCE

por Zhou, Weihua, Yao, Yangyang, Scott, Andrew, Wilder-Romans, Kari, Dresser, Joseph, Werner, Christian, Sun, Hanshi, Pratt, Drew, Sajjakulnukit, Peter, Zaho, Shuang, Davis, Mary, Nelson, Barbara, Halbrook, Christopher, Zhang, Li, Gatto, Francesco, Srinivasan, Sudharsan, Jairath, Neil, Correa, Luis, Umemura, Yoshie, Walker, Angela, Kachman, Maureen, Qi, Nathan, Sarkaria, Jann, Xiong, Jianping, Morgan, Meredith, Rehemtulla, Alnawaz, Castro, Maria, Lowenstein, Pedro, Chandrasekaran, Sriram, Lawrence, Theodore, Lyssiotis, Costas, Wahl, Daniel
Publicado 2021

Uridine-derived ribose fuels glucose-restricted pancreatic cancer

por Nwosu, Zeribe C., Ward, Matthew H., Sajjakulnukit, Peter, Poudel, Pawan, Ragulan, Chanthirika, Kasperek, Steven, Radyk, Megan, Sutton, Damien, Menjivar, Rosa E., Andren, Anthony, Apiz-Saab, Juan J., Tolstyka, Zachary, Brown, Kristee, Lee, Ho-Joon, Dzierozynski, Lindsey N., He, Xi, PS, Hari, Ugras, Julia, Nyamundanda, Gift, Zhang, Li, Halbrook, Christopher J., Carpenter, Eileen S., Shi, Jiaqi, Shriver, Leah P., Patti, Gary J., Muir, Alexander, Pasca di Magliano, Marina, Sadanandam, Anguraj, Lyssiotis, Costas A.
Publicado 2023

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

por Zhou, Weihua, Yao, Yangyang, Scott, Andrew J., Wilder-Romans, Kari, Dresser, Joseph J., Werner, Christian K., Sun, Hanshi, Pratt, Drew, Sajjakulnukit, Peter, Zhao, Shuang G., Davis, Mary, Nelson, Barbara S., Halbrook, Christopher J., Zhang, Li, Gatto, Francesco, Umemura, Yoshie, Walker, Angela K., Kachman, Maureen, Sarkaria, Jann N., Xiong, Jianping, Morgan, Meredith A., Rehemtualla, Alnawaz, Castro, Maria G., Lowenstein, Pedro, Chandrasekaran, Sriram, Lawrence, Theodore S., Lyssiotis, Costas A., Wahl, Daniel R.
Publicado 2020

Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

por Xu, Jianing, Reznik, Ed, Lee, Ho-Joon, Gundem, Gunes, Jonsson, Philip, Sarungbam, Judy, Bialik, Anna, Sanchez-Vega, Francisco, Creighton, Chad J, Hoekstra, Jake, Zhang, Li, Sajjakulnukit, Peter, Kremer, Daniel, Tolstyka, Zachary, Casuscelli, Jozefina, Stirdivant, Steve, Tang, Jie, Schultz, Nikolaus, Jeng, Paul, Dong, Yiyu, Su, Wenjing, Cheng, Emily H, Russo, Paul, Coleman, Jonathan A, Papaemmanuil, Elli, Chen, Ying-Bei, Reuter, Victor E, Sander, Chris, Kennedy, Scott R, Hsieh, James J, Lyssiotis, Costas A, Tickoo, Satish K, Hakimi, A Ari
Publicado 2019

Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

por Kerk, Samuel A, Lin, Lin, Myers, Amy L, Sutton, Damien J, Andren, Anthony, Sajjakulnukit, Peter, Zhang, Li, Zhang, Yaqing, Jiménez, Jennifer A, Nelson, Barbara S, Chen, Brandon, Robinson, Anthony, Thurston, Galloway, Kemp, Samantha B, Steele, Nina G, Hoffman, Megan T, Wen, Hui-Ju, Long, Daniel, Ackenhusen, Sarah E, Ramos, Johanna, Gao, Xiaohua, Nwosu, Zeribe C, Galban, Stefanie, Halbrook, Christopher J, Lombard, David B, Piwnica-Worms, David R, Ying, Haoqiang, Pasca di Magliano, Marina, Crawford, Howard C, Shah, Yatrik M, Lyssiotis, Costas A
Publicado 2022

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

por Halbrook, Christopher J., Thurston, Galloway, Boyer, Seth, Anaraki, Cecily, Jiménez, Jennifer A., McCarthy, Amy, Steele, Nina G., Kerk, Samuel A., Hong, Hanna S., Lin, Lin, Law, Fiona V., Felton, Catherine, Scipioni, Lorenzo, Sajjakulnukit, Peter, Andren, Anthony, Beutel, Alica K., Singh, Rima, Nelson, Barbara S., Van Den Bergh, Fran, Krall, Abigail S., Mullen, Peter J., Zhang, Li, Batra, Sandeep, Morton, Jennifer P., Stanger, Ben Z., Christofk, Heather R., Digman, Michelle A., Beard, Daniel A., Viale, Andrea, Zhang, Ji, Crawford, Howard C., Pasca di Magliano, Marina, Jorgensen, Claus, Lyssiotis, Costas A.
Publicado 2022

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

por Kremer, Daniel M., Nelson, Barbara S., Lin, Lin, Yarosz, Emily L., Halbrook, Christopher J., Kerk, Samuel A., Sajjakulnukit, Peter, Myers, Amy, Thurston, Galloway, Hou, Sean W., Carpenter, Eileen S., Andren, Anthony C., Nwosu, Zeribe C., Cusmano, Nicholas, Wisner, Stephanie, Mbah, Nneka E., Shan, Mengrou, Das, Nupur K., Magnuson, Brian, Little, Andrew C., Savani, Milan R., Ramos, Johanna, Gao, Tina, Sastra, Stephen A., Palermo, Carmine F., Badgley, Michael A., Zhang, Li, Asara, John M., McBrayer, Samuel K., di Magliano, Marina Pasca, Crawford, Howard C., Shah, Yatrik M., Olive, Kenneth P., Lyssiotis, Costas A.
Publicado 2021

GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity

por Watson, Dionysios C., Bayik, Defne, Storevik, Simon, Moreino, Shannon Sherwin, Sprowls, Samuel A., Han, Jianhua, Augustsson, Mina Thue, Lauko, Adam, Sravya, Palavalasa, Røsland, Gro Vatne, Troike, Katie, Tronstad, Karl Johan, Wang, Sabrina, Sarnow, Katharina, Kay, Kristen, Lunavat, Taral R., Silver, Daniel J., Dayal, Sahil, Joseph, Justin Vareecal, Mulkearns-Hubert, Erin, Ystaas, Lars Andreas Rømo, Deshpande, Gauravi, Guyon, Joris, Zhou, Yadi, Magaut, Capucine R., Seder, Juliana, Neises, Laura, Williford, Sarah E., Meiser, Johannes, Scott, Andrew J., Sajjakulnukit, Peter, Mears, Jason A., Bjerkvig, Rolf, Chakraborty, Abhishek, Daubon, Thomas, Cheng, Feixiong, Lyssiotis, Costas A., Wahl, Daniel R., Hjelmeland, Anita B., Hossain, Jubayer A., Miletic, Hrvoje, Lathia, Justin D.
Publicado 2023

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

por Venneti, Sriram, Kawakibi, Abed Rahman, Ji, Sunjong, Waszak, Sebastian M., Sweha, Stefan R., Mota, Mateus, Pun, Matthew, Deogharkar, Akash, Chung, Chan, Tarapore, Rohinton S., Ramage, Samuel, Chi, Andrew, Wen, Patrick Y., Arrillaga-Romany, Isabel, Batchelor, Tracy T., Butowski, Nicholas A., Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca A., de Groot, John, Mehta, Minesh, Hall, Matthew D., Daghistani, Doured, Cloughesy, Timothy F., Ellingson, Benjamin M., Beccaria, Kevin, Varlet, Pascale, Kim, Michelle M., Umemura, Yoshie, Garton, Hugh, Franson, Andrea, Schwartz, Jonathan, Jain, Rajan, Kachman, Maureen, Baum, Heidi, Burant, Charles F., Mottl, Sophie L., Cartaxo, Rodrigo T., John, Vishal, Messinger, Dana, Qin, Tingting, Peterson, Erik, Sajjakulnukit, Peter, Ravi, Karthik, Waugh, Alyssa, Walling, Dustin, Ding, Yujie, Xia, Ziyun, Schwendeman, Anna, Hawes, Debra, Yang, Fusheng, Judkins, Alexander R., Wahl, Daniel, Lyssiotis, Costas A., de la Nava, Daniel, Alonso, Marta M., Eze, Augustine, Spitzer, Jasper, Schmidt, Susanne V., Duchatel, Ryan J., Dun, Matthew D., Cain, Jason E., Jiang, Li, Stopka, Sylwia A., Baquer, Gerard, Regan, Michael S., Filbin, Mariella G., Agar, Nathalie Y.R., Zhao, Lili, Kumar-Sinha, Chandan, Mody, Rajen, Chinnaiyan, Arul, Kurokawa, Ryo, Pratt, Drew, Yadav, Viveka N., Grill, Jacques, Kline, Cassie, Mueller, Sabine, Resnick, Adam, Nazarian, Javad, Allen, Joshua E., Odia, Yazmin, Gardner, Sharon L., Koschmann, Carl
Publicado 2023