In Silico Prediction of the Metabolic Resistance of Vitamin D Analogs against CYP3A4 Metabolizing Enzyme

por Żołek, Teresa, Yasuda, Kaori, Brown, Geoffrey, Sakaki, Toshiyuki, Kutner, Andrzej
Publicado 2022

Mammalian Cytochrome P450-Dependent Metabolism of Polychlorinated Dibenzo-p-dioxins and Coplanar Polychlorinated Biphenyls

por Inui, Hideyuki, Itoh, Toshimasa, Yamamoto, Keiko, Ikushiro, Shin-Ichi, Sakaki, Toshiyuki
Publicado 2014

Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D(3) Analogues and Their Stability to hCYP24A1-Dependent Catabolism

por Kawagoe, Fumihiro, Mototani, Sayuri, Yasuda, Kaori, Mano, Hiroki, Sakaki, Toshiyuki, Kittaka, Atsushi
Publicado 2021

The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D(3) and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities

por Mototani, Sayuri, Kawagoe, Fumihiro, Yasuda, Kaori, Mano, Hiroki, Sakaki, Toshiyuki, Kittaka, Atsushi
Publicado 2022

Biological Evaluation of Double Point Modified Analogues of 1,25-Dihydroxyvitamin D(2) as Potential Anti-Leukemic Agents

por Corcoran, Aoife, Nadkarni, Sharmin, Yasuda, Kaori, Sakaki, Toshiyuki, Brown, Geoffrey, Kutner, Andrzej, Marcinkowska, Ewa
Publicado 2016

Synthesis and CYP24A1-Dependent Metabolism of 23-Fluorinated Vitamin D(3) Analogues

por Kawagoe, Fumihiro, Yasuda, Kaori, Mototani, Sayuri, Sugiyama, Toru, Uesugi, Motonari, Sakaki, Toshiyuki, Kittaka, Atsushi
Publicado 2019

Development of In Vitro and In Vivo Evaluation Systems for Vitamin D Derivatives and Their Application to Drug Discovery

por Yasuda, Kaori, Nishikawa, Miyu, Mano, Hiroki, Takano, Masashi, Kittaka, Atsushi, Ikushiro, Shinichi, Sakaki, Toshiyuki
Publicado 2021

Influence of sesamin on CYP2C-mediated diclofenac metabolism: in vitro and in vivo analysis

por Yasuda, Kaori, Ueno, Sera, Ueda, Erika, Nishikawa, Miyu, Takeda, Kie, Kamakura, Masaki, Ikushiro, Shinichi, Sakaki, Toshiyuki
Publicado 2015

Avian Cytochrome P450 (CYP) 1-3 Family Genes: Isoforms, Evolutionary Relationships, and mRNA Expression in Chicken Liver

por Watanabe, Kensuke P., Kawai, Yusuke K., Ikenaka, Yoshinori, Kawata, Minami, Ikushiro, Shin-Ichi, Sakaki, Toshiyuki, Ishizuka, Mayumi
Publicado 2013

Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D(2) Derivatives Modified at the Side Chain and the...

por Milczarek, Magdalena, Chodyński, Michał, Pietraszek, Anita, Stachowicz-Suhs, Martyna, Yasuda, Kaori, Sakaki, Toshiyuki, Wietrzyk, Joanna, Kutner, Andrzej
Publicado 2020

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice

por Hirota, Yoshihisa, Nakagawa, Kimie, Isomoto, Keigo, Sakaki, Toshiyuki, Kubodera, Noboru, Kamao, Maya, Osakabe, Naomi, Suhara, Yoshitomo, Okano, Toshio
Publicado 2018

Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats

por Nishikawa, Miyu, Murose, Naruhiro, Mano, Hiroki, Yasuda, Kaori, Isogai, Yasuhiro, Kittaka, Atsushi, Takano, Masashi, Ikushiro, Shinichi, Sakaki, Toshiyuki
Publicado 2022

Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D(3) and Identification of Their Metabolites

por Mizumoto, Yuka, Sakamoto, Ryota, Iijima, Kazuto, Nakaya, Naoto, Odagi, Minami, Tera, Masayuki, Hirokawa, Takatsugu, Sakaki, Toshiyuki, Yasuda, Kaori, Nagasawa, Kazuo
Publicado 2023

Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector

por Kise, Satoko, Iijima, Ayano, Nagao, Chika, Okada, Tadashi, Nishikawa, Miyu, Ikushiro, Shinichi, Nakanishi, Tomoko, Sato, Shigeto, Yasuda, Kaori, Sakaki, Toshiyuki
Publicado 2023

Human hepatic metabolism of the anti-osteoporosis drug eldecalcitol involves sterol C4-methyl oxidase

por Yasuda, Kaori, Iwanaga, Yuasa, Ogawa, Kazuaki, Mano, Hiroki, Ueno, Sera, Kimoto, Shutaro, Ohta, Miho, Kamakura, Masaki, Ikushiro, Shinichi, Sakaki, Toshiyuki
Publicado 2015

Microbial production of novel sulphated alkaloids for drug discovery

por Matsumura, Eitaro, Nakagawa, Akira, Tomabechi, Yusuke, Ikushiro, Shinichi, Sakaki, Toshiyuki, Katayama, Takane, Yamamoto, Kenji, Kumagai, Hidehiko, Sato, Fumihiko, Minami, Hiromichi
Publicado 2018

Preparation of a Major Metabolite of Iguratimod and Simultaneous Assay of Iguratimod and Its Metabolite by HPLC in Rat Plasma

por Han, Jun-ping, Zhu, Zhen-han, Wu, Yue-zhang, Qian, Wen, Li, Zhi-yu, Nishikawa, Miyu, Sakaki, Toshiyuki, Yang, Chang-qing
Publicado 2019

Characterization of Rickets Type II Model Rats to Reveal Functions of Vitamin D and Vitamin D Receptor

por Iwai, Yuichiro, Iijima, Ayano, Kise, Satoko, Nagao, Chika, Senda, Yuto, Yabu, Kana, Mano, Hiroki, Nishikawa, Miyu, Ikushiro, Shinichi, Yasuda, Kaori, Sakaki, Toshiyuki
Publicado 2023

Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system

por Yasuda, Kaori, Nishikawa, Miyu, Okamoto, Kairi, Horibe, Kyohei, Mano, Hiroki, Yamaguchi, Mana, Okon, Risa, Nakagawa, Kimie, Tsugawa, Naoko, Okano, Toshio, Kawagoe, Fumihiro, Kittaka, Atsushi, Ikushiro, Shinichi, Sakaki, Toshiyuki
Publicado 2021

Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions

por Nishikawa, Miyu, Yasuda, Kaori, Takamatsu, Masashi, Abe, Keisuke, Okamoto, Kairi, Horibe, Kyohei, Mano, Hiroki, Nakagawa, Kimie, Tsugawa, Naoko, Hirota, Yoshihisa, Horie, Tetsuhiro, Hinoi, Eiichi, Okano, Toshio, Ikushiro, Shinichi, Sakaki, Toshiyuki
Publicado 2020