Use of Tox21 Screening Data to Evaluate the COVID-19 Drug Candidates for Their Potential Toxic Effects and Related Pathways

por Sakamuru, Srilatha, Huang, Ruili, Xia, Menghang
Publicado 2022

HTS-Compatible β-Lactamase Transcriptional Reporter Gene Assay for Interrogating the Heat Shock Response Pathway

por Hancock, Michael K, Xia, Menghang, Frey, Elizabeth S, Sakamuru, Srilatha, Bi, Kun
Publicado 2009

Identification of Angiogenesis Inhibitors Using a Co-culture Cell Model in a High-Content and High-Throughput Screening Platform

por Li, Shuaizhang, Hsu, Chia-Wen, Sakamuru, Srilatha, Zou, Chaozhong, Huang, Ruili, Xia, Menghang
Publicado 2017

Identification of Compounds for Butyrylcholinesterase Inhibition

por Li, Shuaizhang, Li, Andrew J., Travers, Jameson, Xu, Tuan, Sakamuru, Srilatha, Klumpp-Thomas, Carleen, Huang, Ruili, Xia, Menghang
Publicado 2021

Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles

por Huang, Ruili, Xia, Menghang, Sakamuru, Srilatha, Zhao, Jinghua, Lynch, Caitlin, Zhao, Tongan, Zhu, Hu, Austin, Christopher P., Simeonov, Anton
Publicado 2018

Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays

por Lynch, Caitlin, Zhao, Jinghua, Sakamuru, Srilatha, Zhang, Li, Huang, Ruili, Witt, Kristine L., Merrick, B. Alex, Teng, Christina T., Xia, Menghang
Publicado 2019

High-Throughput Screening to Predict Chemical-Assay Interference

por Borrel, Alexandre, Huang, Ruili, Sakamuru, Srilatha, Xia, Menghang, Simeonov, Anton, Mansouri, Kamel, Houck, Keith A., Judson, Richard S., Kleinstreuer, Nicole C.
Publicado 2020

Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization

por Huang, Ruili, Xia, Menghang, Sakamuru, Srilatha, Zhao, Jinghua, Shahane, Sampada A., Attene-Ramos, Matias, Zhao, Tongan, Austin, Christopher P., Simeonov, Anton
Publicado 2016

Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wil...

por Vazquez-Ortiz, Guelaguetza, Chisholm, Cristine, Xu, Xiaoling, Lahusen, Tyler J, Li, Cuiling, Sakamuru, Srilatha, Huang, Ruili, Thomas, Craig J, Xia, Menghang, Deng, Chuxia
Publicado 2014

Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics

por Zhu, Hu, Chen, Catherine Z., Sakamuru, Srilatha, Zhao, Jinghua, Ngan, Deborah K., Simeonov, Anton, Hall, Mathew D., Xia, Menghang, Zheng, Wei, Huang, Ruili
Publicado 2021

Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform

por Kabir, Md, Padilha, Elias C., Shah, Pranav, Huang, Ruili, Sakamuru, Srilatha, Gonzalez, Eric, Ye, Lin, Hu, Xin, Henderson, Mark J., Xia, Menghang, Xu, Xin
Publicado 2022

Identification of small molecule compounds that inhibit the HIF-1 signaling pathway

por Xia, Menghang, Bi, Kun, Huang, Ruili, Cho, Ming-Hsuang, Sakamuru, Srilatha, Miller, Susanne C, Li, Hua, Sun, Yi, Printen, John, Austin, Christopher P, Inglese, James
Publicado 2009

Identification of repurposed small molecule drugs for chordoma therapy

por Xia, Menghang, Huang, Ruili, Sakamuru, Srilatha, Alcorta, David, Cho, Ming-Hsuang, Lee, Dae-Hee, Park, Deric M, Kelley, Michael J, Sommer, Josh, Austin, Christopher P
Publicado 2013

Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors

por Huang, Ruili, Xia, Menghang, Cho, Ming-Hsuang, Sakamuru, Srilatha, Shinn, Paul, Houck, Keith A., Dix, David J., Judson, Richard S., Witt, Kristine L., Kavlock, Robert J., Tice, Raymond R., Austin, Christopher P.
Publicado 2011

Development and Validation of a Computational Model for Androgen Receptor Activity

por Kleinstreuer, Nicole C., Ceger, Patricia, Watt, Eric D., Martin, Matthew, Houck, Keith, Browne, Patience, Thomas, Russell S., Casey, Warren M., Dix, David J., Allen, David, Sakamuru, Srilatha, Xia, Menghang, Huang, Ruili, Judson, Richard
Publicado 2016

Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library

por Paul-Friedman, Katie, Martin, Matt, Crofton, Kevin M., Hsu, Chia-Wen, Sakamuru, Srilatha, Zhao, Jinghua, Xia, Menghang, Huang, Ruili, Stavreva, Diana A., Soni, Vikas, Varticovski, Lyuba, Raziuddin, Razi, Hager, Gordon L., Houck, Keith A.
Publicado 2019

Methylene blue is a potent and broad-spectrum inhibitor against Zika virus in vitro and in vivo

por Li, Zhong, Lang, Yuekun, Sakamuru, Srilatha, Samrat, Subodh, Trudeau, Nicole, Kuo, Lili, Rugenstein, Natasha, Tharappel, Anil, D'Brant, Lianna, Koetzner, Cheri A., Hu, Saiyang, Zhang, Jing, Huang, Ruili, Kramer, Laura D., Butler, David, Xia, Menghang, Li, Hongmin
Publicado 2020

Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition

por Li, Shuaizhang, Zhao, Jinghua, Huang, Ruili, Travers, Jameson, Klumpp-Thomas, Carleen, Yu, Wenbo, MacKerell, Alexander D., Sakamuru, Srilatha, Ooka, Masato, Xue, Fengtian, Sipes, Nisha S., Hsieh, Jui-Hua, Ryan, Kristen, Simeonov, Anton, Santillo, Michael F., Xia, Menghang
Publicado 2021

Population-Based in Vitro Hazard and Concentration–Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study

por Abdo, Nour, Xia, Menghang, Brown, Chad C., Kosyk, Oksana, Huang, Ruili, Sakamuru, Srilatha, Zhou, Yi-Hui, Jack, John R., Gallins, Paul, Xia, Kai, Li, Yun, Chiu, Weihsueh A., Motsinger-Reif, Alison A., Austin, Christopher P., Tice, Raymond R., Rusyn, Ivan, Wright, Fred A.
Publicado 2015

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

por Huang, Ruili, Sakamuru, Srilatha, Martin, Matt T., Reif, David M., Judson, Richard S., Houck, Keith A., Casey, Warren, Hsieh, Jui-Hua, Shockley, Keith R., Ceger, Patricia, Fostel, Jennifer, Witt, Kristine L., Tong, Weida, Rotroff, Daniel M., Zhao, Tongan, Shinn, Paul, Simeonov, Anton, Dix, David J., Austin, Christopher P., Kavlock, Robert J., Tice, Raymond R., Xia, Menghang
Publicado 2014