Optimization of a siRNA Carrier Modified with a pH-Sensitive Cationic Lipid and a Cyclic RGD Peptide for Efficiently Targeting Tumor Endothelial Cells

por Hada, Tomoya, Sakurai, Yu, Harashima, Hideyoshi
Publicado 2015

Targeting Tumor Endothelial Cells with Nanoparticles

por Sakurai, Yu, Akita, Hidetaka, Harashima, Hideyoshi
Publicado 2019

Optimization of Sentinel Lymph Node Imaging Methodology Using Anionic Liposome and Hyaluronidase

por Sakurai, Yu, Suzuoki, Miho, Gomi, Masaki, Tanaka, Hiroki, Akita, Hidetaka
Publicado 2021

Effective Therapy Using a Liposomal siRNA that Targets the Tumor Vasculature in a Model Murine Breast Cancer with Lung Metastasis

por Sakurai, Yu, Hada, Tomoya, Kato, Akari, Hagino, Yuta, Mizumura, Wataru, Harashima, Hideyoshi
Publicado 2018

Development of Sentinel LN Imaging with a Combination of HAase Based on a Comprehensive Analysis of the Intra-lymphatic Kinetics of LPs

por Gomi, Masaki, Sakurai, Yu, Okada, Takaharu, Miura, Naoya, Tanaka, Hiroki, Akita, Hidetaka
Publicado 2021

Silencing of VEGFR2 by RGD-Modified Lipid Nanoparticles Enhanced the Efficacy of Anti-PD-1 Antibody by Accelerating Vascular Normalization and Infiltration of T Cells in Tumors

por Cho, Riki, Sakurai, Yu, Jones, Haleigh Sakura, Akita, Hidetaka, Hisaka, Akihiro, Hatakeyama, Hiroto
Publicado 2020

Development of an Alcohol Dilution–Lyophilization Method for the Preparation of mRNA-LNPs with Improved Storage Stability

por Shirane, Daiki, Tanaka, Hiroki, Sakurai, Yu, Taneichi, Sakura, Nakai, Yuta, Tange, Kota, Ishii, Itsuko, Akita, Hidetaka
Publicado 2023

Improvement of mRNA Delivery Efficiency to a T Cell Line by Modulating PEG-Lipid Content and Phospholipid Components of Lipid Nanoparticles

por Tanaka, Hiroki, Miyama, Ryo, Sakurai, Yu, Tamagawa, Shinya, Nakai, Yuta, Tange, Kota, Yoshioka, Hiroki, Akita, Hidetaka
Publicado 2021

Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes

por Hayashi, Yasuhiro, Suemitsu, Erina, Kajimoto, Kazuaki, Sato, Yusuke, Akhter, Afsana, Sakurai, Yu, Hatakeyama, Hiroto, Hyodo, Mamoru, Kaji, Noritada, Baba, Yoshinobu, Harashima, Hideyoshi
Publicado 2014

Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material

por Tanaka, Hiroki, Takata, Nae, Sakurai, Yu, Yoshida, Tokuyuki, Inoue, Takao, Tamagawa, Shinya, Nakai, Yuta, Tange, Kota, Yoshioka, Hiroki, Maeki, Masatoshi, Tokeshi, Manabu, Akita, Hidetaka
Publicado 2021

Tolerogenic Lipid Nanoparticles for Delivering Self-Antigen mRNA for the Treatment of Experimental Autoimmune Encephalomyelitis

por Gomi, Masaki, Nakayama, Yuka, Sakurai, Yu, Oyama, Ryotaro, Iwasaki, Koki, Doi, Mizuki, Liu, Yi, Hori, Mizuho, Watanabe, Himeka, Hashimoto, Kohei, Tanaka, Hiroki, Tange, Kota, Nakai, Yuta, Akita, Hidetaka
Publicado 2023

pH-Responsive Lipid Nanoparticles Achieve Efficient mRNA Transfection in Brain Capillary Endothelial Cells

por Sakurai, Yu, Watanabe, Himeka, Nishio, Kazuma, Hashimoto, Kohei, Harada, Atsuki, Gomi, Masaki, Suzuki, Masayoshi, Oyama, Ryotaro, Handa, Takumi, Sato, Risa, Takeuchi, Hina, Taira, Ryoga, Tezuka, Kenta, Tange, Kota, Nakai, Yuta, Akita, Hidetaka, Uchida, Yasuo
Publicado 2022

An Ionizable Lipid Material with a Vitamin E Scaffold as an mRNA Vaccine Platform for Efficient Cytotoxic T Cell Responses

por Oyama, Ryotaro, Ishigame, Harumichi, Tanaka, Hiroki, Tateshita, Naho, Itazawa, Moeko, Imai, Ryosuke, Nishiumi, Naomasa, Kishikawa, Jun-ichi, Kato, Takayuki, Anindita, Jessica, Nishikawa, Yoshifumi, Maeki, Masatoshi, Tokeshi, Manabu, Tange, Kota, Nakai, Yuta, Sakurai, Yu, Okada, Takaharu, Akita, Hidetaka
Publicado 2023

Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell‐specific liposomal siRNA delivery system

por Maishi, Nako, Sakurai, Yu, Hatakeyama, Hiroto, Umeyama, Yui, Nakamura, Takashi, Endo, Rikito, Alam, Mohammad Towfik, Li, Cong, Annan, Dorcas Akuba‐Muhyia, Kikuchi, Hiroshi, Morimoto, Hirofumi, Morimoto, Masahiro, Akiyama, Kosuke, Ohga, Noritaka, Hida, Yasuhiro, Harashima, Hideyoshi, Hida, Kyoko
Publicado 2022