Impact of CNS Diseases on Drug Delivery to Brain Extracellular and Intracellular Target Sites in Human: A “WHAT-IF” Simulation Study

por Saleh, Mohammed A. A., de Lange, Elizabeth C. M.
Publicado 2021

The Extension of the LeiCNS-PK3.0 Model in Combination with the “Handshake” Approach to Understand Brain Tumor Pathophysiology

por Hirasawa, Makoto, Saleh, Mohammed A. A., de Lange, Elizabeth C. M.
Publicado 2022

Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC(50) Values in Aging and Alzheimer’s Disease, Using the Physiologically Based LeiCNS-PK3.0 Model

por Saleh, Mohammed A. A., Bloemberg, Julia S., Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C. M.
Publicado 2022

Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations

por Saleh, Mohammed A. A., Loo, Chi Fong, Elassaiss-Schaap, Jeroen, De Lange, Elizabeth C. M.
Publicado 2021

The PBPK LeiCNS-PK3.0 framework predicts Nirmatrelvir (but not Remdesivir or Molnupiravir) to achieve effective concentrations against SARS-CoV-2 in human brain cells

por Saleh, Mohammed A.A., Hirasawa, Makoto, Sun, Ming, Gülave, Berfin, Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C.M.
Publicado 2023

Biomarker‐Guided Individualization of Antibiotic Therapy

por Aulin, Linda B.S., de Lange, Dylan W., Saleh, Mohammed A.A., van der Graaf, Piet H., Völler, Swantje, van Hasselt, J.G. Coen
Publicado 2021

Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations

por Aulin, Linda B. S., Tandar, Sebastian T., van Zijp, Torben, van Ballegooie, Etienne, van der Graaf, Piet H., Saleh, Mohammed A. A., Välitalo, Pyry, van Hasselt, J. G. Coen
Publicado 2022