Targeting the CDK6 Dependence of Ph+ Acute Lymphoblastic Leukemia

por Porazzi, Patrizia, De Dominici, Marco, Salvino, Joseph, Calabretta, Bruno
Publicado 2021

Targeting cancer metabolism in the era of precision oncology

por Stine, Zachary E., Schug, Zachary T., Salvino, Joseph M., Dang, Chi V.
Publicado 2021

Functional Characterization of the Dopaminergic Psychostimulant Sydnocarb as an Allosteric Modulator of the Human Dopamine Transporter

por Aggarwal, Shaili, Cheng, Mary Hongying, Salvino, Joseph M., Bahar, Ivet, Mortensen, Ole Valente
Publicado 2021

Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation

por Cui, Yange, Wang, Luyang, Ding, Qingbao, Shin, Jihae, Cassel, Joel, Liu, Qin, Salvino, Joseph M., Tian, Bin
Publicado 2023

Use of hyphenated analytical techniques to identify the bioactive constituents of Gunnera perpensa L., a South African medicinal plant, which potently inhibit SARS-CoV-2 spike glyc...

por Invernizzi, Luke, Moyo, Phanankosi, Cassel, Joel, Isaacs, Freddie J., Salvino, Joseph M., Montaner, Luis J., Tietjen, Ian, Maharaj, Vinesh
Publicado 2022

Small molecule perturbation of the CAND1-Cullin1-ubiquitin cycle stabilizes p53 and triggers Epstein-Barr virus reactivation

por Tikhmyanova, Nadezhda, Tutton, Steve, Martin, Kayla A., Lu, Fang, Kossenkov, Andrew V., Paparoidamis, Nicholas, Kenney, Shannon, Salvino, Joseph M., Lieberman, Paul M.
Publicado 2017

Preclinical platforms to study therapeutic efficacy of human γδ T cells

por Ou, Lingling, Wang, Huaishan, Huang, Hui, Zhou, Zhiyan, Lin, Qiang, Guo, Yeye, Mitchell, Tara, Huang, Alexander C., Karakousis, Giorgos, Schuchter, Lynn, Amaravadi, Ravi, Guo, Wei, Salvino, Joseph, Herlyn, Meenhard, Xu, Xiaowei
Publicado 2022

The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants

por Tietjen, Ian, Cassel, Joel, Register, Emery T., Zhou, Xiang Yang, Messick, Troy E., Keeney, Frederick, Lu, Lily D., Beattie, Karren D., Rali, Topul, Tebas, Pablo, Ertl, Hildegund C. J., Salvino, Joseph M., Davis, Rohan A., Montaner, Luis J.
Publicado 2021

HSP70 Inhibition Blocks Adaptive Resistance and Synergizes with MEK Inhibition for the Treatment of NRAS-Mutant Melanoma

por Parris, Joshua L.D., Barnoud, Thibaut, Leu, Julia I.-Ju, Leung, Jessica C., Ma, Weili, Kirven, Nicole A., Poli, Adi Naryana Reddy, Kossenkov, Andrew V., Liu, Qin, Salvino, Joseph M., George, Donna L., Weeraratna, Ashani T., Chen, Qing, Murphy, Maureen E.
Publicado 2021

IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance

por Singh, Kumar Sachin, Sharma, Rishabh, Reddy, Poli Adi Narayana, Vonteddu, Prashanthi, Good, Madeline, Sundarrajan, Anjana, Choi, Hyeree, Muthumani, Kar, Kossenkov, Andrew, Goldman, Aaron R., Tang, Hsin-Yao, Totrov, Maxim, Cassel, Joel, Murphy, Maureen E., Somasundaram, Rajasekharan, Herlyn, Meenhard, Salvino, Joseph M., Dotiwala, Farokh
Publicado 2021

Metabolic control of BRISC-SHMT2 assembly regulates immune signaling

por Walden, Miriam, Tian, Lei, Ross, Rebecca, Sykora, Upasana M., Byrne, Dominic P., Hesketh, Emma L., Masandi, Safi K., Cassel, Joel, George, Rachel, Ault, James R., El Oualid, Farid, Pawłowski, Krzysztof, Salvino, Joseph M., Eyers, Patrick A., Ranson, Neil A., Del Galdo, Francesco, Greenberg, Roger A., Zeqiraj, Elton
Publicado 2019

Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability

por Ghosh, Jagadish C., Perego, Michela, Agarwal, Ekta, Bertolini, Irene, Wang, Yuan, Goldman, Aaron R., Tang, Hsin-Yao, Kossenkov, Andrew V., Landis, Catherine J., Languino, Lucia R., Plow, Edward F., Morotti, Annamaria, Ottobrini, Luisa, Locatelli, Marco, Speicher, David W., Caino, M. Cecilia, Cassel, Joel, Salvino, Joseph M., Robert, Marie E., Vaira, Valentina, Altieri, Dario C.
Publicado 2022

Increased glucose availability sensitizes pancreatic cancer to chemotherapy

por Vaziri-Gohar, Ali, Hue, Jonathan J., Abbas, Ata, Graor, Hallie J., Hajihassani, Omid, Zarei, Mehrdad, Titomihelakis, George, Feczko, John, Rathore, Moeez, Chelstowska, Sylwia, Loftus, Alexander W., Wang, Rui, Zarei, Mahsa, Goudarzi, Maryam, Zhang, Renliang, Willard, Belinda, Zhang, Li, Kresak, Adam, Willis, Joseph E., Wang, Gi-Ming, Tatsuoka, Curtis, Salvino, Joseph M., Bederman, Ilya, Brunengraber, Henri, Lyssiotis, Costas A., Brody, Jonathan R., Winter, Jordan M.
Publicado 2023

Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

por Vaziri-Gohar, Ali, Cassel, Joel, Mohammed, Farheen S., Zarei, Mehrdad, Hue, Jonathan J., Hajihassani, Omid, Graor, Hallie J., Srikanth, Yellamelli V. V., Karim, Saadia A., Abbas, Ata, Prendergast, Erin, Chen, Vanessa, Katayama, Erryk S., Dukleska, Katerina, Khokhar, Imran, Andren, Anthony, Zhang, Li, Wu, Chunying, Erokwu, Bernadette, Flask, Chris A., Zarei, Mahsa, Wang, Rui, Rothermel, Luke D., Romani, Andrea M. P., Bowers, Jessica, Getts, Robert, Tatsuoka, Curtis, Morton, Jennifer P., Bederman, Ilya, Brunengraber, Henri, Lyssiotis, Costas A., Salvino, Joseph M., Brody, Jonathan R., Winter, Jordan M.
Publicado 2022

Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance

por Liu, Jianglan, Rebecca, Vito W., Kossenkov, Andrew V., Connelly, Thomas, Liu, Qin, Gutierrez, Alexis, Xiao, Min, Li, Ling, Zhang, Gao, Samarkina, Anastasia, Zayasbazan, Delaine, Zhang, Jie, Cheng, Chaoran, Wei, Zhi, Alicea, Gretchen M., Fukunaga-Kalabis, Mizuho, Krepler, Clemens, Aza-Blanc, Pedro, Yang, Chih-Cheng, Delvadia, Bela, Tong, Cynthia, Huang, Ye, Delvadia, Maya, Morias, Alice S., Sproesser, Katrin, Brafford, Patricia, Wang, Joshua X., Beqiri, Marilda, Somasundaram, Rajasekharan, Vultur, Adina, Hristova, Denitsa M., Wu, Lawrence W., Lu, Yiling, Mills, Gordon B., Xu, Wei, Karakousis, Giorgos C., Xu, Xiaowei, Schuchter, Lynn M., Mitchell, Tara C., Amaravadi, Ravi K., Kwong, Lawrence N., Frederick, Dennie T., Boland, Genevieve M., Salvino, Joseph M., Speicher, David W., Flaherty, Keith T., Ronai, Ze'ev A., Herlyn, Meenhard
Publicado 2021