Microclusters as T Cell Signaling Hubs: Structure, Kinetics, and Regulation

por Balagopalan, Lakshmi, Raychaudhuri, Kumarkrishna, Samelson, Lawrence E.
Publicado 2021

Cytoskeletal forces during signaling activation in Jurkat T-cells

por Hui, King Lam, Balagopalan, Lakshmi, Samelson, Lawrence E., Upadhyaya, Arpita
Publicado 2015

Cish attenuates proximal TCR-signaling and CD8+ T cell immunity

por Palmer, Douglas, Guittard, Geoffery, Patel, Shashank, Samelson, Lawrence E, Restifo, Nicholas P
Publicado 2014

TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps

por Yi, Jason, Balagopalan, Lakshmi, Nguyen, Tiffany, McIntire, Katherine M., Samelson, Lawrence E.
Publicado 2019

Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7

por Dios-Esponera, Ana, Melis, Nicolas, Subramanian, Bhagawat C., Weigert, Roberto, Samelson, Lawrence E.
Publicado 2019

ZAP-70 Association with T Cell Receptor ζ (TCRζ): Fluorescence Imaging of Dynamic Changes upon Cellular Stimulation

por Sloan-Lancaster, Joanne, Presley, John, Ellenberg, Jan, Yamazaki, Tetsuo, Lippincott-Schwartz, Jennifer, Samelson, Lawrence E.
Publicado 1998

Association of the Adaptor Molecule Lat with Cd4 and Cd8 Coreceptors Identifies a New Coreceptor Function in T Cell Receptor Signal Transduction

por Bosselut, Rémy, Zhang, Weiguo, Ashe, Jennifer M., Kopacz, Jeffrey L., Samelson, Lawrence E., Singer, Alfred
Publicado 1999

madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy

por Yi, Jason, Manna, Asit, Barr, Valarie A., Hong, Jennifer, Neuman, Keir C., Samelson, Lawrence E.
Publicado 2016

Knock-in Mutation of the Distal Four Tyrosines of Linker for Activation of T Cells Blocks Murine T Cell Development

por Sommers, Connie L., Menon, Rashmi K., Grinberg, Alexander, Zhang, Weiguo, Samelson, Lawrence E., Love, Paul E.
Publicado 2001

Hierarchical nanostructure and synergy of multimolecular signalling complexes

por Sherman, Eilon, Barr, Valarie A., Merrill, Robert K., Regan, Carole K., Sommers, Connie L., Samelson, Lawrence E.
Publicado 2016

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

por Balagopalan, Lakshmi, Yi, Jason, Nguyen, Tiffany, McIntire, Katherine M., Harned, Adam S., Narayan, Kedar, Samelson, Lawrence E.
Publicado 2018

The Four Distal Tyrosines Are Required for LAT-dependent Signaling in FcɛRI-mediated Mast Cell Activation

por Saitoh, Shin-ichiroh, Odom, Sandra, Gomez, Gregorio, Sommers, Connie L., Young, Howard A., Rivera, Juan, Samelson, Lawrence E.
Publicado 2003

Regulation of ZAP-70 Intracellular Localization: Visualization with the Green Fluorescent Protein

por Sloan-Lancaster, Joanne, Zhang, Weiguo, Presley, John, Williams, Brandi L., Abraham, Robert T., Lippincott-Schwartz, Jennifer, Samelson, Lawrence E.
Publicado 1997

Inactivation of c-Cbl Reverses Neonatal Lethality and T Cell Developmental Arrest of SLP-76–deficient Mice

por Chiang, Y. Jeffrey, Sommers, Connie L., Jordan, Martha S., Gu, Hua, Samelson, Lawrence E., Koretzky, Gary A., Hodes, Richard J.
Publicado 2004

In vitro reconstitution reveals cooperative mechanisms of adapter protein-mediated activation of phospholipase C-γ1 in T cells

por Wada, Junya, Rathnayake, Udumbara, Jenkins, Lisa M., Singh, Avinash, Mohammadi, Moosa, Appella, Ettore, Randazzo, Paul A., Samelson, Lawrence E.
Publicado 2022

Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8(+) T Cell Expansion and Differentiation

por Dimitriou, Ioannis D., Lee, Korris, Akpan, Itoro, Lind, Evan F., Barr, Valarie A., Ohashi, Pamela S., Samelson, Lawrence E., Rottapel, Robert
Publicado 2018

Bypassing ubiquitination enables LAT recycling to the cell surface and enhanced signaling in T cells

por Balagopalan, Lakshmi, Malik, Hiba, McIntire, Katherine M., Garvey, Joseph A., Nguyen, Tiffany, Rodriguez-Peña, Ana B., Samelson, Lawrence E.
Publicado 2020

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

por Bunnell, Stephen C., Hong, David I., Kardon, Julia R., Yamazaki, Tetsuo, McGlade, C. Jane, Barr, Valarie A., Samelson, Lawrence E.
Publicado 2002

miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways

por Rouquette-Jazdanian, Alexandre K., Kortum, Robert L., Li, Wenmei, Merrill, Robert K., Nguyen, Phan H., Samelson, Lawrence E., Sommers, Connie L.
Publicado 2015

The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8(+) T cells

por Guittard, Geoffrey, Dios-Esponera, Ana, Palmer, Douglas C., Akpan, Itoro, Barr, Valarie A., Manna, Asit, Restifo, Nicholas P., Samelson, Lawrence E.
Publicado 2018