Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells

por Samson, Andre L., Ho, Bosco, Au, Amanda E., Schoenwaelder, Simone M., Smyth, Mark J., Bottomley, Stephen P., Kleifeld, Oded, Medcalf, Robert L.
Publicado 2016

Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling

por Meng, Yanxiang, Horne, Christopher R., Samson, Andre L., Dagley, Laura F., Young, Samuel N., Sandow, Jarrod J., Czabotar, Peter E., Murphy, James M.
Publicado 2022

Development of a carotid artery thrombolysis stroke model in mice

por Maclean, Jessica A. A., Tomkins, Amelia J., Sturgeon, Sharelle A., Hofma, Benjamin R., Alwis, Imala, Samson, Andre L., Schoenwaelder, Simone M., Jackson, Shaun P.
Publicado 2022

Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin

por Borg, Rachael J., Samson, Andre L., Au, Amanda E.-L., Scholzen, Anja, Fuchsberger, Martina, Kong, Ying Y., Freeman, Roxann, Mifsud, Nicole A., Plebanski, Magdalena, Medcalf, Robert L.
Publicado 2015

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

por Samson, Andre L., Ju, Lining, Ah Kim, Hyun, Zhang, Shenpeng R., Lee, Jessica A. A., Sturgeon, Sharelle A., Sobey, Christopher G., Jackson, Shaun P., Schoenwaelder, Simone M.
Publicado 2015

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

por Meng, Yanxiang, Davies, Katherine A., Fitzgibbon, Cheree, Young, Samuel N., Garnish, Sarah E., Horne, Christopher R., Luo, Cindy, Garnier, Jean-Marc, Liang, Lung-Yu, Cowan, Angus D., Samson, Andre L., Lessene, Guillaume, Sandow, Jarrod J., Czabotar, Peter E., Murphy, James M.
Publicado 2021

The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

por Jacobsen, Annette V., Pierotti, Catia L., Lowes, Kym N., Au, Amanda E., Zhang, Ying, Etemadi, Nima, Fitzgibbon, Cheree, Kersten, Wilhelmus J. A., Samson, André L., van Delft, Mark F., Huang, David C. S., Sabroux, Hélène Jousset, Lessene, Guillaume, Silke, John, Murphy, James M.
Publicado 2022

Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death

por Liu, Lin, Sandow, Jarrod J., Leslie Pedrioli, Deena M., Samson, Andre L., Silke, Natasha, Kratina, Tobias, Ambrose, Rebecca L., Doerflinger, Marcel, Hu, Zhaoqing, Morrish, Emma, Chau, Diep, Kueh, Andrew J., Fitzibbon, Cheree, Pellegrini, Marc, Pearson, Jaclyn S., Hottiger, Michael O., Webb, Andrew I., Lalaoui, Najoua, Silke, John
Publicado 2022

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

por Garnish, Sarah E., Meng, Yanxiang, Koide, Akiko, Sandow, Jarrod J., Denbaum, Eric, Jacobsen, Annette V., Yeung, Wayland, Samson, Andre L., Horne, Christopher R., Fitzgibbon, Cheree, Young, Samuel N., Smith, Phoebe P. C., Webb, Andrew I., Petrie, Emma J., Hildebrand, Joanne M., Kannan, Natarajan, Czabotar, Peter E., Koide, Shohei, Murphy, James M.
Publicado 2021

Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria

por Bader, Stefanie M., Preston, Simon P., Saliba, Katie, Lipszyc, Adam, Grant, Zoe L., Mackiewicz, Liana, Baldi, Andrew, Hempel, Anne, Clark, Michelle P., Peiris, Thanushi, Clow, William, Bjelic, Jan, Stutz, Michael D., Arandjelovic, Philip, Teale, Jack, Du, Fashuo, Coultas, Leigh, Murphy, James M., Allison, Cody C., Pellegrini, Marc, Samson, Andre L.
Publicado 2022

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

por Tovey Crutchfield, Emma C., Garnish, Sarah E., Day, Jessica, Anderton, Holly, Chiou, Shene, Hempel, Anne, Hall, Cathrine, Patel, Komal M., Gangatirkar, Pradnya, Martin, Katherine R., Li Wai Suen, Connie S. N., Garnham, Alexandra L., Kueh, Andrew J., Wicks, Ian P., Silke, John, Nachbur, Ueli, Samson, Andre L., Murphy, James M., Hildebrand, Joanne M.
Publicado 2023

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

por Frank, Daniel, Garnish, Sarah E., Sandow, Jarrod J., Weir, Ashley, Liu, Lin, Clayer, Elise, Meza, Lizeth, Rashidi, Maryam, Cobbold, Simon A., Scutts, Simon R., Doerflinger, Marcel, Anderton, Holly, Lawlor, Kate E., Lalaoui, Najoua, Kueh, Andrew J., Eng, Vik Ven, Ambrose, Rebecca L., Herold, Marco J., Samson, Andre L., Feltham, Rebecca, Murphy, James M., Ebert, Gregor, Pearson, Jaclyn S., Vince, James E.
Publicado 2022

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

por Samson, Andre L., Zhang, Ying, Geoghegan, Niall D., Gavin, Xavier J., Davies, Katherine A., Mlodzianoski, Michael J., Whitehead, Lachlan W., Frank, Daniel, Garnish, Sarah E., Fitzgibbon, Cheree, Hempel, Anne, Young, Samuel N., Jacobsen, Annette V., Cawthorne, Wayne, Petrie, Emma J., Faux, Maree C., Shield-Artin, Kristy, Lalaoui, Najoua, Hildebrand, Joanne M., Silke, John, Rogers, Kelly L., Lessene, Guillaume, Hawkins, Edwin D., Murphy, James M.
Publicado 2020

VDAC2 enables BAX to mediate apoptosis and limit tumor development

por Chin, Hui San, Li, Mark X., Tan, Iris K. L., Ninnis, Robert L., Reljic, Boris, Scicluna, Kristen, Dagley, Laura F., Sandow, Jarrod J., Kelly, Gemma L., Samson, Andre L., Chappaz, Stephane, Khaw, Seong L., Chang, Catherine, Morokoff, Andrew, Brinkmann, Kerstin, Webb, Andrew, Hockings, Colin, Hall, Cathrine M., Kueh, Andrew J., Ryan, Michael T., Kluck, Ruth M., Bouillet, Philippe, Herold, Marco J., Gray, Daniel H. D., Huang, David C. S., van Delft, Mark F., Dewson, Grant
Publicado 2018

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

por Yu, Chien-Hsiung, Davidson, Sophia, Harapas, Cassandra R., Hilton, James B., Mlodzianoski, Michael J., Laohamonthonkul, Pawat, Louis, Cynthia, Low, Ronnie Ren Jie, Moecking, Jonas, De Nardo, Dominic, Balka, Katherine R., Calleja, Dale J., Moghaddas, Fiona, Ni, Erya, McLean, Catriona A., Samson, Andre L., Tyebji, Shiraz, Tonkin, Christopher J., Bye, Christopher R., Turner, Bradley J., Pepin, Genevieve, Gantier, Michael P., Rogers, Kelly L., McArthur, Kate, Crouch, Peter J., Masters, Seth L.
Publicado 2020

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

por Garnish, Sarah E., Martin, Katherine R., Kauppi, Maria, Jackson, Victoria E., Ambrose, Rebecca, Eng, Vik Ven, Chiou, Shene, Meng, Yanxiang, Frank, Daniel, Tovey Crutchfield, Emma C., Patel, Komal M., Jacobsen, Annette V., Atkin-Smith, Georgia K., Di Rago, Ladina, Doerflinger, Marcel, Horne, Christopher R., Hall, Cathrine, Young, Samuel N., Cook, Matthew, Athanasopoulos, Vicki, Vinuesa, Carola G., Lawlor, Kate E., Wicks, Ian P., Ebert, Gregor, Ng, Ashley P., Slade, Charlotte A., Pearson, Jaclyn S., Samson, André L., Silke, John, Murphy, James M., Hildebrand, Joanne M.
Publicado 2023