Alkylation induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins

por Bugni, James M., Meira, Lisiane B., Samson, Leona D.
Publicado 2008

Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response

por Beharry, Andrew A., Nagel, Zachary D., Samson, Leona D., Kool, Eric T.
Publicado 2016

The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury

por Yu, Amy Marie, Calvo, Jennifer A., Muthupalani, Suresh, Samson, Leona D.
Publicado 2016

Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae

por Mazumder, Aprotim, Pesudo, Laia Quiros, McRee, Siobhan, Bathe, Mark, Samson, Leona D.
Publicado 2013

Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms

por Margulies, Carrie M., Chaim, Isaac Alexander, Mazumder, Aprotim, Criscione, June, Samson, Leona D.
Publicado 2017

Both base excision repair and O(6)-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis

por Wirtz, Stefan, Nagel, Georg, Eshkind, Leonid, Neurath, Markus F., Samson, Leona D., Kaina, Bernd
Publicado 2010

Identification of Novel Human Damage Response Proteins Targeted through Yeast Orthology

por Svensson, J. Peter, Fry, Rebecca C., Wang, Emma, Somoza, Luis A., Samson, Leona D.
Publicado 2012

PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration

por Allocca, Mariacarmela, Corrigan, Joshua J., Fake, Kimberly R., Calvo, Jennifer A., Samson, Leona D.
Publicado 2017

Microcolony Size Distribution Assay Enables High-Throughput Cell Survival Quantitation

por Ngo, Le P., Chan, Tze Khee, Ge, Jing, Samson, Leona D., Engelward, Bevin P.
Publicado 2019

Structural Basis for the Inhibition of Human Alkyladenine DNA Glycosylase (AAG) by 3,N(4)-Ethenocytosine-containing DNA

por Lingaraju, Gondichatnahalli M., Davis, C. Ainsley, Setser, Jeremy W., Samson, Leona D., Drennan, Catherine L.
Publicado 2011

Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA Glycosylase

por Setser, Jeremy W., Lingaraju, Gondichatnahalli M., Davis, C. Ainsley, Samson, Leona D., Drennan, Catherine L.
Publicado 2011

A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N(4)-ethenocytosine

por Chaim, Isaac A., Gardner, Alycia, Wu, Jie, Iyama, Teruaki, Wilson, David M., Samson, Leona D.
Publicado 2017

Anc1, a Protein Associated with Multiple Transcription Complexes, Is Involved in Postreplication Repair Pathway in S. cerevisiae

por Erlich, Rachel L., Fry, Rebecca C., Begley, Thomas J., Daee, Danielle L., Lahue, Robert S., Samson, Leona D.
Publicado 2008

Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance

por Svensson, J Peter, Pesudo, Laia Quirós, Fry, Rebecca C, Adeleye, Yeyejide A, Carmichael, Paul, Samson, Leona D
Publicado 2011

Genomic Phenotyping by Barcode Sequencing Broadly Distinguishes between Alkylating Agents, Oxidizing Agents, and Non-Genotoxic Agents, and Reveals a Role for Aromatic Amino Acids i...

por Svensson, J. Peter, Quirós Pesudo, Laia, McRee, Siobhan K., Adeleye, Yeyejide, Carmichael, Paul, Samson, Leona D.
Publicado 2013

The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA

por Fry, Rebecca C, DeMott, Michael S, Cosgrove, Joseph P, Begley, Thomas J, Samson, Leona D, Dedon, Peter C
Publicado 2006

Transcriptional Networks in S. cerevisiae Linked to an Accumulation of Base Excision Repair Intermediates

por Rusyn, Ivan, Fry, Rebecca C., Begley, Thomas J., Klapacz, Joanna, Svensson, J. Peter, Ambrose, Mark, Samson, Leona D.
Publicado 2007

Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress

por Tentner, Andrea R, Lee, Michael J, Ostheimer, Gerry J, Samson, Leona D, Lauffenburger, Douglas A, Yaffe, Michael B
Publicado 2012

Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner

por Calvo, Jennifer A., Allocca, Mariacarmela, Fake, Kimberly R., Muthupalani, Sureshkumar, Corrigan, Joshua J., Bronson, Roderick T., Samson, Leona D.
Publicado 2016

DNA Polymerases β and λ Mediate Overlapping and Independent Roles in Base Excision Repair in Mouse Embryonic Fibroblasts

por Braithwaite, Elena K., Kedar, Padmini S., Stumpo, Deborah J., Bertocci, Barbara, Freedman, Jonathan H., Samson, Leona D., Wilson, Samuel H.
Publicado 2010