Physiological Brain Activity Causes DNA Double Strand Breaks in Neurons — Exacerbation by Amyloid-β

por Suberbielle, Elsa, Sanchez, Pascal E., Kravitz, Alexxai V., Wang, Xin, Ho, Kaitlyn, Eilertson, Kirsten, Devidze, Nino, Kreitzer, Anatol C., Mucke, Lennart
Publicado 2013

Tau Reduction Prevents Disease in a Mouse Model of Dravet Syndrome

por Gheyara, Ania L, Ponnusamy, Ravikumar, Djukic, Biljana, Craft, Ryan J, Ho, Kaitlyn, Guo, Weikun, Finucane, Mariel M, Sanchez, Pascal E, Mucke, Lennart
Publicado 2014

Standardized Environmental Enrichment Supports Enhanced Brain Plasticity in Healthy Rats and Prevents Cognitive Impairment in Epileptic Rats

por Fares, Raafat P., Belmeguenai, Amor, Sanchez, Pascal E., Kouchi, Hayet Y., Bodennec, Jacques, Morales, Anne, Georges, Béatrice, Bonnet, Chantal, Bouvard, Sandrine, Sloviter, Robert S., Bezin, Laurent
Publicado 2013

Network dysfunction in α‐synuclein transgenic mice and human Lewy body dementia

por Morris, Meaghan, Sanchez, Pascal E., Verret, Laure, Beagle, Alexander J., Guo, Weikun, Dubal, Dena, Ranasinghe, Kamalini G., Koyama, Akihiko, Ho, Kaitlyn, Yu, Gui‐Qiu, Vossel, Keith A., Mucke, Lennart
Publicado 2015

Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer’s disease mutations but not by...

por Johnson, Erik C. B., Ho, Kaitlyn, Yu, Gui-Qiu, Das, Melanie, Sanchez, Pascal E., Djukic, Biljana, Lopez, Isabel, Yu, Xinxing, Gill, Michael, Zhang, Weiping, Paz, Jeanne T., Palop, Jorge J., Mucke, Lennart
Publicado 2020

Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome

por Arguello, Annie, Meisner, René, Thomsen, Elliot R., Nguyen, Hoang N., Ravi, Ritesh, Simms, Jeffrey, Lo, Iris, Speckart, Jessica, Holtzman, Julia, Gill, Thomas M., Chan, Darren, Cheng, Yuhsiang, Chiu, Chi-Lu, Dugas, Jason C., Fang, Meng, Lopez, Isabel A., Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Zhu, Yuda, Bhalla, Akhil, Henne, Kirk R., Henry, Anastasia G., Delucchi, Anthony, Costanzo, Simona, Harris, Jeffrey M., Diaz, Dolores, Scearce-Levie, Kimberly, Sanchez, Pascal E.
Publicado 2021

Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme

por Arguello, Annie, Mahon, Cathal S., Calvert, Meredith E.K., Chan, Darren, Dugas, Jason C., Pizzo, Michelle E., Thomsen, Elliot R., Chau, Roni, Damo, Lorna A., Duque, Joseph, Fang, Meng, Giese, Tina, Kim, Do Jin, Liang, Nicholas, Nguyen, Hoang N., Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Ullman, Julie C., Wang, Junhua, Dennis, Mark S., Diaz, Dolores, Gunasekaran, Kannan, Henne, Kirk R., Lewcock, Joseph W., Sanchez, Pascal E., Troyer, Matthew D., Harris, Jeffrey M., Scearce-Levie, Kimberly, Shan, Lu, Watts, Ryan J., Thorne, Robert G., Henry, Anastasia G., Kariolis, Mihalis S.
Publicado 2022

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

por Xia, Dan, Lianoglou, Steve, Sandmann, Thomas, Calvert, Meredith, Suh, Jung H., Thomsen, Elliot, Dugas, Jason, Pizzo, Michelle E., DeVos, Sarah L., Earr, Timothy K., Lin, Chia-Ching, Davis, Sonnet, Ha, Connie, Leung, Amy Wing-Sze, Nguyen, Hoang, Chau, Roni, Yulyaningsih, Ernie, Lopez, Isabel, Solanoy, Hilda, Masoud, Shababa T., Liang, Chun-chi, Lin, Karin, Astarita, Giuseppe, Khoury, Nathalie, Zuchero, Joy Yu, Thorne, Robert G., Shen, Kevin, Miller, Stephanie, Palop, Jorge J., Garceau, Dylan, Sasner, Michael, Whitesell, Jennifer D., Harris, Julie A., Hummel, Selina, Gnörich, Johannes, Wind, Karin, Kunze, Lea, Zatcepin, Artem, Brendel, Matthias, Willem, Michael, Haass, Christian, Barnett, Daniel, Zimmer, Till S., Orr, Anna G., Scearce-Levie, Kimberly, Lewcock, Joseph W., Di Paolo, Gilbert, Sanchez, Pascal E.
Publicado 2022

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

por van Lengerich, Bettina, Zhan, Lihong, Xia, Dan, Chan, Darren, Joy, David, Park, Joshua I., Tatarakis, David, Calvert, Meredith, Hummel, Selina, Lianoglou, Steve, Pizzo, Michelle E., Prorok, Rachel, Thomsen, Elliot, Bartos, Laura M., Beumers, Philipp, Capell, Anja, Davis, Sonnet S., de Weerd, Lis, Dugas, Jason C., Duque, Joseph, Earr, Timothy, Gadkar, Kapil, Giese, Tina, Gill, Audrey, Gnörich, Johannes, Ha, Connie, Kannuswamy, Malavika, Kim, Do Jin, Kunte, Sebastian T., Kunze, Lea H., Lac, Diana, Lechtenberg, Kendra, Leung, Amy Wing-Sze, Liang, Chun-Chi, Lopez, Isabel, McQuade, Paul, Modi, Anuja, Torres, Vanessa O., Nguyen, Hoang N., Pesämaa, Ida, Propson, Nicholas, Reich, Marvin, Robles-Colmenares, Yaneth, Schlepckow, Kai, Slemann, Luna, Solanoy, Hilda, Suh, Jung H., Thorne, Robert G., Vieira, Chandler, Wind-Mark, Karin, Xiong, Ken, Zuchero, Y. Joy Yu, Diaz, Dolo, Dennis, Mark S., Huang, Fen, Scearce-Levie, Kimberly, Watts, Ryan J., Haass, Christian, Lewcock, Joseph W., Di Paolo, Gilbert, Brendel, Matthias, Sanchez, Pascal E., Monroe, Kathryn M.
Publicado 2023