Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues

por Hassan, Muhammad Murtaza, Li, Yen-Der, Ma, Michelle W., Teng, Mingxing, Byun, Woong Sub, Puvar, Kedar, Lumpkin, Ryan, Sandoval, Brittany, Rutter, Justine C., Jin, Cyrus Y., Wang, Michelle Y., Xu, Shawn, Schmoker, Anna M., Cheong, Hakyung, Groendyke, Brian J., Qi, Jun, Fischer, Eric S., Ebert, Benjamin L., Gray, Nathanael S.
Publicado 2023

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

por Li, Yen-Der, Ma, Michelle W., Hassan, Muhammad Murtaza, Hunkeler, Moritz, Teng, Mingxing, Puvar, Kedar, Lumpkin, Ryan, Sandoval, Brittany, Jin, Cyrus Y., Ficarro, Scott B., Wang, Michelle Y., Xu, Shawn, Groendyke, Brian J., Sigua, Logan H., Tavares, Isidoro, Zou, Charles, Tsai, Jonathan M., Park, Paul M. C., Yoon, Hojong, Majewski, Felix C., Marto, Jarrod A., Qi, Jun, Nowak, Radosław P., Donovan, Katherine A., Słabicki, Mikołaj, Gray, Nathanael S., Fischer, Eric S., Ebert, Benjamin L.
Publicado 2023

Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells

por Sellar, Rob S., Sperling, Adam S., Słabicki, Mikołaj, Gasser, Jessica A., McConkey, Marie E., Donovan, Katherine A., Mageed, Nada, Adams, Dylan N., Zou, Charles, Miller, Peter G., Dutta, Ravi K., Boettcher, Steffen, Lin, Amy E., Sandoval, Brittany, Quevedo Barrios, Vanessa A., Kovalcik, Veronica, Koeppel, Jonas, Henderson, Elizabeth K., Fink, Emma C., Yang, Lu, Chan, Anthony, Pokharel, Sheela Pangeni, Bergstrom, Erik J., Burt, Rajan, Udeshi, Namrata D., Carr, Steven A., Fischer, Eric S., Chen, Chun-Wei, Ebert, Benjamin L.
Publicado 2022

Association of clonal hematopoiesis with chronic obstructive pulmonary disease

por Miller, Peter G., Qiao, Dandi, Rojas-Quintero, Joselyn, Honigberg, Michael C., Sperling, Adam S., Gibson, Christopher J., Bick, Alexander G., Niroula, Abhishek, McConkey, Marie E., Sandoval, Brittany, Miller, Brian C., Shi, Weiwei, Viswanathan, Kaushik, Leventhal, Matthew, Werner, Lillian, Moll, Matthew, Cade, Brian E., Barr, R. Graham, Correa, Adolfo, Cupples, L. Adrienne, Gharib, Sina A., Jain, Deepti, Gogarten, Stephanie M., Lange, Leslie A., London, Stephanie J., Manichaikul, Ani, O’Connor, George T., Oelsner, Elizabeth C., Redline, Susan, Rich, Stephen S., Rotter, Jerome I., Ramachandran, Vasan, Yu, Bing, Sholl, Lynette, Neuberg, Donna, Jaiswal, Siddhartha, Levy, Bruce D., Owen, Caroline A., Natarajan, Pradeep, Silverman, Edwin K., van Galen, Peter, Tesfaigzi, Yohannes, Cho, Michael H., Ebert, Benjamin L.
Publicado 2022