Genetic screens in isogenic mammalian cell lines without single cell cloning

por DeWeirdt, Peter C., Sangree, Annabel K., Hanna, Ruth E., Sanson, Kendall R., Hegde, Mudra, Strand, Christine, Persky, Nicole S., Doench, John G.
Publicado 2020

Efficient gene knockout and genetic interactions: the IN4MER CRISPR/Cas12a multiplex knockout platform

por Anvar, Nazanin Esmaeili, Lin, Chenchu, Ma, Xingdi, Wilson, Lori L., Steger, Ryan, Sangree, Annabel K., Colic, Medina, Wang, Sidney H., Doench, John G., Hart, Traver
Publicado 2023

Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2

por Sangree, Annabel K., Griffith, Audrey L., Szegletes, Zsofia M., Roy, Priyanka, DeWeirdt, Peter C., Hegde, Mudra, McGee, Abby V., Hanna, Ruth E., Doench, John G.
Publicado 2022

Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells

por Lenoir, W. Frank, Morgado, Micaela, DeWeirdt, Peter C., McLaughlin, Megan, Griffith, Audrey L., Sangree, Annabel K., Feeley, Marissa N., Esmaeili Anvar, Nazanin, Kim, Eiru, Bertolet, Lori L., Colic, Medina, Dede, Merve, Doench, John G., Hart, Traver
Publicado 2021

Optimization of AsCas12a for combinatorial genetic screens in human cells

por DeWeirdt, Peter C, Sanson, Kendall R, Sangree, Annabel K, Hegde, Mudra, Hanna, Ruth E, Feeley, Marissa N, Griffith, Audrey L, Teng, Teng, Borys, Samantha M, Strand, Christine, Joung, J Keith, Kleinstiver, Benjamin P, Pan, Xuewen, Huang, Alan, Doench, John G
Publicado 2020