Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

por Jiao, Haihan, Rutar, Matt, Fernando, Nilisha, Yednock, Ted, Sankaranarayanan, Sethu, Aggio-Bruce, Riemke, Provis, Jan, Natoli, Riccardo
Publicado 2018

Safety and Target Engagement of Complement C1q Inhibitor ANX007 in Neurodegenerative Eye Disease: Results from Phase I Studies in Glaucoma

por Sun, Yang, Wirta, David, Murahashi, Wendy, Mathur, Vidhu, Sankaranarayanan, Sethu, Taylor, Lori K., Yednock, Ted, Fong, Donald S., Goldberg, Jeffrey L.
Publicado 2023

The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA

por Vukojicic, Aleksandra, Delestrée, Nicolas, Fletcher, Emily V., Pagiazitis, John G., Sankaranarayanan, Sethu, Yednock, Ted A., Barres, Ben A., Mentis, George Z.
Publicado 2019

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy

por McGonigal, Rhona, Cunningham, Madeleine E., Yao, Denggao, Barrie, Jennifer A., Sankaranarayanan, Sethu, Fewou, Simon N., Furukawa, Koichi, Yednock, Ted A., Willison, Hugh J.
Publicado 2016

Pharmacokinetic and Target Engagement Measures of ANX007, an Anti-C1q Antibody Fragment, Following Intravitreal Administration in Nonhuman Primates

por Grover, Anita, Sankaranarayanan, Sethu, Mathur, Vidhu, Suri, Poojan, Qiu, Haiyan, Andrews-Zwilling, Yaisa, Mease, Kirsten, Taylor, Lori K., Cahir-McFarland, Ellen, Keswani, Sanjay, Yednock, Ted
Publicado 2023

Characterization of Novel CSF Tau and ptau Biomarkers for Alzheimer’s Disease

por Meredith Jr., Jere E., Sankaranarayanan, Sethu, Guss, Valerie, Lanzetti, Anthony J., Berisha, Flora, Neely, Robert J., Slemmon, J. Randall, Portelius, Erik, Zetterberg, Henrik, Blennow, Kaj, Soares, Holly, Ahlijanian, Michael, Albright, Charles F.
Publicado 2013

Viable mouse gene ablations that robustly alter brain Aβ levels are rare

por Toyn, Jeremy H, Lin, Xu-Alan, Thompson, Mark W, Guss, Valerie, Meredith, Jere E, Sankaranarayanan, Sethu, Barrezueta, Nestor, Corradi, John, Majumdar, Antara, Small, Daniel L, Hansard, Melissa, Lanthorn, Thomas, Westphal, Ryan S, Albright, Charles F
Publicado 2010

Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease

por Wes, Paul D., Easton, Amy, Corradi, John, Barten, Donna M., Devidze, Nino, DeCarr, Lynn B., Truong, Amy, He, Aiqing, Barrezueta, Nestor X., Polson, Craig, Bourin, Clotilde, Flynn, Marianne E., Keenan, Stefanie, Lidge, Regina, Meredith, Jere, Natale, Joanne, Sankaranarayanan, Sethu, Cadelina, Greg W., Albright, Charlie F., Cacace, Angela M.
Publicado 2014

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models

por Sankaranarayanan, Sethu, Barten, Donna M., Vana, Laurel, Devidze, Nino, Yang, Ling, Cadelina, Gregory, Hoque, Nina, DeCarr, Lynn, Keenan, Stefanie, Lin, Alan, Cao, Yang, Snyder, Bradley, Zhang, Bin, Nitla, Magdalena, Hirschfeld, Gregg, Barrezueta, Nestor, Polson, Craig, Wes, Paul, Rangan, Vangipuram S., Cacace, Angela, Albright, Charles F., Meredith, Jere, Trojanowski, John Q., Lee, Virginia M-Y., Brunden, Kurt R., Ahlijanian, Michael
Publicado 2015