Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates

por Simone, Davide, Penkava, Frank, Ridley, Anna, Sansom, Stephen, Al-Mossawi, M. Hussein, Bowness, Paul
Publicado 2021

IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors

por Swann, James W., Koneva, Lada A., Regan-Komito, Daniel, Sansom, Stephen N., Powrie, Fiona, Griseri, Thibault
Publicado 2020

The long non-coding RNA Dali is an epigenetic regulator of neural differentiation

por Chalei, Vladislava, Sansom, Stephen N, Kong, Lesheng, Lee, Sheena, Montiel, Juan F, Vance, Keith W, Ponting, Chris P
Publicado 2014

GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis

por Regan-Komito, Daniel, Swann, James W., Demetriou, Philippos, Cohen, E. Suzanne, Horwood, Nicole J., Sansom, Stephen N., Griseri, Thibault
Publicado 2020

RBFOX splicing factors contribute to a broad but selective recapitulation of peripheral tissue splicing patterns in the thymus

por Jansen, Kathrin, Shikama-Dorn, Noriko, Attar, Moustafa, Maio, Stefano, Lopopolo, Maria, Buck, David, Holländer, Georg A., Sansom, Stephen N.
Publicado 2021

The long non-coding RNA Paupar regulates the expression of both local and distal genes

por Vance, Keith W, Sansom, Stephen N, Lee, Sheena, Chalei, Vladislava, Kong, Lesheng, Cooper, Sarah E, Oliver, Peter L, Ponting, Chris P
Publicado 2014

Reversible Block of Mouse Neural Stem Cell Differentiation in the Absence of Dicer and MicroRNAs

por Andersson, Therese, Rahman, Sabhi, Sansom, Stephen N., Alsiö, Jessica M., Kaneda, Masahiro, Smith, James, O'Carroll, Donal, Tarakhovsky, Alexander, Livesey, Frederick J.
Publicado 2010

The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis

por Sansom, Stephen N., Griffiths, Dean S., Faedo, Andrea, Kleinjan, Dirk-Jan, Ruan, Youlin, Smith, James, van Heyningen, Veronica, Rubenstein, John L., Livesey, Frederick J.
Publicado 2009

Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

por Sansom, Stephen N., Shikama-Dorn, Noriko, Zhanybekova, Saule, Nusspaumer, Gretel, Macaulay, Iain C., Deadman, Mary E., Heger, Andreas, Ponting, Chris P., Holländer, Georg A.
Publicado 2014

Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia

por Mc Fie, Megan, Koneva, Lada, Collins, Isabella, Coveney, Clarissa R., Clube, Aisling M., Chanalaris, Anastasios, Vincent, Tonia L., Bezbradica, Jelena S., Sansom, Stephen N., Wann, Angus K. T.
Publicado 2020

CGAT: computational genomics analysis toolkit

por Sims, David, Ilott, Nicholas E., Sansom, Stephen N., Sudbery, Ian M., Johnson, Jethro S., Fawcett, Katherine A., Berlanga-Taylor, Antonio J., Luna-Valero, Sebastian, Ponting, Chris P., Heger, Andreas
Publicado 2014

Author Correction: Cellular census of human fibrosis defines functionally distinct stromal cell types and states

por Layton, Thomas B., Williams, Lynn, McCann, Fiona, Zhang, Mingjun, Fritzsche, Marco, Colin-York, Huw, Cabrita, Marisa, Ng, Michael T. H., Feldmann, Marc, Sansom, Stephen N., Furniss, Dominic, Xie, Weilin, Nanchahal, Jagdeep
Publicado 2020

Dynamic spatio‐temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla

por Mayer, Carlos E., Žuklys, Saulius, Zhanybekova, Saule, Ohigashi, Izumi, Teh, Hong‐Ying, Sansom, Stephen N., Shikama‐Dorn, Noriko, Hafen, Katrin, Macaulay, Iain C., Deadman, Mary E., Ponting, Chris P., Takahama, Yousuke, Holländer, Georg A.
Publicado 2016

IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells

por Mazet, Julie M., Mahale, Jagdish N., Tong, Orion, Watson, Robert A., Lechuga‐Vieco, Ana Victoria, Pirgova, Gabriela, Lau, Vivian W. C., Attar, Moustafa, Koneva, Lada A., Sansom, Stephen N., Fairfax, Benjamin P., Gérard, Audrey
Publicado 2023

Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis

por Seneviratne, Anusha N., Edsfeldt, Andreas, Cole, Jennifer E., Kassiteridi, Christina, Swart, Maarten, Park, Inhye, Green, Patricia, Khoyratty, Tariq, Saliba, David, Goddard, Michael E., Sansom, Stephen N., Goncalves, Isabel, Krams, Rob, Udalova, Irina A., Monaco, Claudia
Publicado 2017

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

por Haenseler, Walther, Sansom, Stephen N., Buchrieser, Julian, Newey, Sarah E., Moore, Craig S., Nicholls, Francesca J., Chintawar, Satyan, Schnell, Christian, Antel, Jack P., Allen, Nicholas D., Cader, M. Zameel, Wade-Martins, Richard, James, William S., Cowley, Sally A.
Publicado 2017

Pax6 Exerts Regional Control of Cortical Progenitor Proliferation via Direct Repression of Cdk6 and Hypophosphorylation of pRb

por Mi, Da, Carr, Catherine B., Georgala, Petrina A., Huang, Yu-Ting, Manuel, Martine N., Jeanes, Emily, Niisato, Emi, Sansom, Stephen N., Livesey, Frederick J., Theil, Thomas, Hasenpusch-Theil, Kerstin, Simpson, T. Ian, Mason, John O., Price, David J.
Publicado 2013

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

por Schulthess, Julie, Pandey, Sumeet, Capitani, Melania, Rue-Albrecht, Kevin C., Arnold, Isabelle, Franchini, Fanny, Chomka, Agnieszka, Ilott, Nicholas E., Johnston, Daniel G.W., Pires, Elisabete, McCullagh, James, Sansom, Stephen N., Arancibia-Cárcamo, Carolina V., Uhlig, Holm H., Powrie, Fiona
Publicado 2019

Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites

por MacLean, Andrew J., Richmond, Niamh, Koneva, Lada, Attar, Moustafa, Medina, Cesar A.P., Thornton, Emily E., Gomes, Ariane Cruz, El-Turabi, Aadil, Bachmann, Martin F., Rijal, Pramila, Tan, Tiong Kit, Townsend, Alain, Sansom, Stephen N., Bannard, Oliver, Arnon, Tal I.
Publicado 2022

Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury

por Cross, Amy R., de Andrea, Carlos E., Villalba-Esparza, María, Landecho, Manuel F., Cerundolo, Lucia, Weeratunga, Praveen, Etherington, Rachel E., Denney, Laura, Ogg, Graham, Ho, Ling-Pei, Roberts, Ian S.D., Hester, Joanna, Klenerman, Paul, Melero, Ignacio, Sansom, Stephen N., Issa, Fadi
Publicado 2023