Targeting the PI3K/AKT pathway: a potential new weapon in the global fight against SARS-CoV-2?

por Santamaria, Salvatore
Publicado 2021

ADAMTS proteases in cardiovascular physiology and disease

por Santamaria, Salvatore, de Groot, Rens
Publicado 2020

The Role of ADAMTS Proteoglycanases in Thoracic Aortic Disease

por Kemberi, Marsioleda, Salmasi, Yousuf, Santamaria, Salvatore
Publicado 2023

Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition

por Cuffaro, Doretta, Ciccone, Lidia, Rossello, Armando, Nuti, Elisa, Santamaria, Salvatore
Publicado 2022

Proteomic discovery of substrates of the cardiovascular protease ADAMTS7

por Colige, Alain, Monseur, Christine, Crawley, James T. B., Santamaria, Salvatore, de Groot, Rens
Publicado 2019

The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity

por Minns, Alexander Frederick, Qi, Yawei, Yamamoto, Kazuhiro, Lee, Karen, Ahnström, Josefin, Santamaria, Salvatore
Publicado 2023

Editorial: ADAM, ADAMTS and astacin proteases: Challenges and breakthroughs in the -Omics era-Volume II

por Kwok, Hang Fai, Yamamoto, Kazuhiro, de Groot, Rens, Scilabra, Simone Dario, Santamaria, Salvatore
Publicado 2023

Editorial: ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era

por Yamamoto, Kazuhiro, de Groot, Rens, Scilabra, Simone Dario, Kwok, Hang Fai, Santamaria, Salvatore
Publicado 2021

Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8

por Santamaria, Salvatore, Martin, Daniel R., Dong, Xiangyi, Yamamoto, Kazuhiro, Apte, Suneel S., Ahnström, Josefin
Publicado 2021

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1

por Santamaria, Salvatore, Fedorov, Oleg, McCafferty, John, Murphy, Gillian, Dudhia, Jayesh, Nagase, Hideaki, Yamamoto, Kazuhiro
Publicado 2017

Inhibition of Shedding of Low‐Density Lipoprotein Receptor–Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis

por Yamamoto, Kazuhiro, Santamaria, Salvatore, Botkjaer, Kenneth A., Dudhia, Jayesh, Troeberg, Linda, Itoh, Yoshifumi, Murphy, Gillian, Nagase, Hideaki
Publicado 2017

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)

por Santamaria, Salvatore, Yamamoto, Kazuhiro, Botkjaer, Kenneth, Tape, Christopher, Dyson, Michael R., McCafferty, John, Murphy, Gillian, Nagase, Hideaki
Publicado 2015

Factor V has an anticoagulant cofactor activity that targets the early phase of coagulation

por Santamaria, Salvatore, Reglińska-Matveyev, Natalia, Gierula, Magdalena, Camire, Rodney M., Crawley, James T. B., Lane, David A., Ahnström, Josefin
Publicado 2017

Exosites in Hypervariable Loops of ADAMTS Spacer Domains control Substrate Recognition and Proteolysis

por Santamaria, Salvatore, Yamamoto, Kazuhiro, Teraz-Orosz, Adrienn, Koch, Christopher, Apte, Suneel S., de Groot, Rens, Lane, David A., Ahnström, Josefin
Publicado 2019

The roles of factor Va and protein S in formation of the activated protein C/protein S/factor Va inactivation complex

por Gierula, Magdalena, Salles‐Crawley, Isabelle I., Santamaria, Salvatore, Teraz‐Orosz, Adrienn, Crawley, James T. B., Lane, David A., Ahnström, Josefin
Publicado 2019

Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

por Santamaria, Salvatore, Cuffaro, Doretta, Nuti, Elisa, Ciccone, Lidia, Tuccinardi, Tiziano, Liva, Francesca, D’Andrea, Felicia, de Groot, Rens, Rossello, Armando, Ahnström, Josefin
Publicado 2021

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

por Yamamoto, Kazuhiro, Okano, Hiroshi, Miyagawa, Wakako, Visse, Robert, Shitomi, Yasuyuki, Santamaria, Salvatore, Dudhia, Jayesh, Troeberg, Linda, Strickland, Dudley K., Hirohata, Satoshi, Nagase, Hideaki
Publicado 2016

Laminin G1 residues of protein S mediate its TFPI cofactor function and are competitively regulated by C4BP

por Teraz-Orosz, Adrienn, Gierula, Magdalena, Petri, Anastasis, Jones, David, Keniyopoullos, Renos, Folgado, Patricia Badia, Santamaria, Salvatore, Crawley, James T. B., Lane, David A., Ahnström, Josefin
Publicado 2022

Development of a fluorogenic ADAMTS-7 substrate

por Santamaria, Salvatore, Buemi, Frederic, Nuti, Elisa, Cuffaro, Doretta, De Vita, Elena, Tuccinardi, Tiziano, Rossello, Armando, Howell, Steven, Mehmood, Shahid, Snijders, Ambrosius P., de Groot, Rens
Publicado 2021

Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

por Botkjaer, Kenneth A., Kwok, Hang Fai, Terp, Mikkel G., Karatt-Vellatt, Aneesh, Santamaria, Salvatore, McCafferty, John, Andreasen, Peter A., Itoh, Yoshifumi, Ditzel, Henrik J., Murphy, Gillian
Publicado 2016