Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer

por Huang, Can, Iovanna, Juan, Santofimia-Castaño, Patricia
Publicado 2021

NUPR1: A Critical Regulator of the Antioxidant System

por Huang, Can, Santofimia-Castaño, Patricia, Iovanna, Juan
Publicado 2021

Dissecting the Anticancer Mechanism of Trifluoperazine on Pancreatic Ductal Adenocarcinoma

por Huang, Can, Lan, Wenjun, Fraunhoffer, Nicolas, Meilerman, Analía, Iovanna, Juan, Santofimia-Castaño, Patricia
Publicado 2019

Targeting intrinsically disordered proteins involved in cancer

por Santofimia-Castaño, Patricia, Rizzuti, Bruno, Xia, Yi, Abian, Olga, Peng, Ling, Velázquez-Campoy, Adrián, Neira, José L., Iovanna, Juan
Publicado 2019

NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner

por Huang, Can, Santofimia-Castaño, Patricia, Liu, Xi, Xia, Yi, Peng, Ling, Gotorbe, Célia, Neira, Jose Luis, Tang, Daolin, Pouyssegur, Jacques, Iovanna, Juan
Publicado 2021

E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments

por Lan, Wenjun, Bian, Benjamin, Xia, Yi, Dou, Samir, Gayet, Odile, Bigonnet, Martin, Santofimia-Castaño, Patricia, Cong, Mei, Peng, Ling, Dusetti, Nelson, Iovanna, Juan
Publicado 2018

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

por Santofimia-Castaño, Patricia, Lan, Wenjun, Bintz, Jennifer, Gayet, Odile, Carrier, Alice, Lomberk, Gwen, Neira, José Luis, González, Antonio, Urrutia, Raul, Soubeyran, Philippe, Iovanna, Juan
Publicado 2018

Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function

por Rizzuti, Bruno, Lan, Wenjun, Santofimia-Castaño, Patricia, Zhou, Zhengwei, Velázquez-Campoy, Adrián, Abián, Olga, Peng, Ling, Neira, José L., Xia, Yi, Iovanna, Juan L.
Publicado 2021

NUPR1 protects against hyperPARylation-dependent cell death

por Santofimia-Castaño, Patricia, Huang, Can, Liu, Xi, Xia, Yi, Audebert, Stephane, Camoin, Luc, Peng, Ling, Lomberk, Gwen, Urrutia, Raul, Soubeyran, Philippe, Neira, Jose Luis, Iovanna, Juan
Publicado 2022

Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma

por Santofimia-Castaño, Patricia, Xia, Yi, Peng, Ling, Velázquez-Campoy, Adrián, Abián, Olga, Lan, Wenjun, Lomberk, Gwen, Urrutia, Raul, Rizzuti, Bruno, Soubeyran, Philippe, Neira, José Luis, Iovanna, Juan
Publicado 2019

ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

por Lan, Wenjun, Santofimia-Castaño, Patricia, Swayden, Mirna, Xia, Yi, Zhou, Zhengwei, Audebert, Stephane, Camoin, Luc, Huang, Can, Peng, Ling, Jiménez-Alesanco, Ana, Velázquez-Campoy, Adrián, Abián, Olga, Lomberk, Gwen, Urrutia, Raul, Rizzuti, Bruno, Geli, Vincent, Soubeyran, Philippe, Neira, José L., Iovanna, Juan
Publicado 2020

Melatonin controls cell proliferation and modulates mitochondrial physiology in pancreatic stellate cells

por Estaras, Matias, Ortiz-Placin, Candido, Castillejo-Rufo, Alba, Fernandez-Bermejo, Miguel, Blanco, Gerardo, Mateos, Jose M., Vara, Daniel, Gonzalez-Cordero, Pedro L., Chamizo, Sandra, Lopez, Diego, Rojas, Adela, Jaen, Isabel, de Armas, Noelia, Salido, Gines M., Iovanna, Juan L., Santofimia-Castaño, Patricia, Gonzalez, Antonio
Publicado 2022

Melatonin modulates red-ox state and decreases viability of rat pancreatic stellate cells

por Gonzalez, Antonio, Estaras, Matias, Martinez-Morcillo, Salome, Martinez, Remigio, García, Alfredo, Estévez, Mario, Santofimia-Castaño, Patricia, Tapia, Jose A., Moreno, Noelia, Pérez-López, Marcos, Míguez, María P., Blanco-Fernández, Gerardo, Lopez-Guerra, Diego, Fernandez-Bermejo, Miguel, Mateos, Jose M., Vara, Daniel, Roncero, Vicente, Salido, Gines M.
Publicado 2020