An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy

por Cowles, Sarah C., Sheen, Allison, Santollani, Luciano, Lutz, Emi A., Lax, Brianna M., Palmeri, Joseph R., Freeman, Gordon J., Wittrup, K. Dane
Publicado 2022

Tregs constrain CD8(+) T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy

por Palmeri, Joseph R., Lax, Brianna M., Peters, Joshua M., Duhamel, Lauren, Stinson, Jordan A., Santollani, Luciano, Lutz, Emi A., Pinney, William, Bryson, Bryan D., Wittrup, K. Dane
Publicado 2023

Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity

por Agarwal, Yash, Milling, Lauren E., Chang, Jason Y.H., Santollani, Luciano, Sheen, Allison, Lutz, Emi A., Tabet, Anthony, Stinson, Jordan, Ni, Kaiyuan, Rodrigues, Kristen A., Moyer, Tyson J., Melo, Mariane B., Irvine, Darrell J., Wittrup, K. Dane
Publicado 2022