Drugging Sphingosine Kinases

por Santos, Webster L., Lynch, Kevin R.
Publicado 2014

Mechanism of sphingosine 1-phosphate clearance from blood

por Kharel, Yugesh, Huang, Tao, Salamon, Anita, Harris, Thurl E., Santos, Webster L., Lynch, Kevin R.
Publicado 2020

Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor...

por Adamiak, Mateusz, Chelvarajan, Lakshman, Lynch, Kevin R., Santos, Webster L., Abdel-Latif, Ahmed, Ratajczak, Mariusz Z.
Publicado 2017

Correction: Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem...

por Adamiak, Mateusz, Chelvarajan, Lakshman, Lynch, Kevin R., Santos, Webster L., Abdel-Latif, Ahmed, Ratajczak, Mariusz Z.
Publicado 2018

Regio‐ and Stereoselective Synthesis of 1,1‐Diborylalkenes via Brønsted Base‐Catalyzed Mixed Diboration of Alkynyl Esters and Amides with BpinBdan

por Liu, Xiaocui, Ming, Wenbo, Luo, Xiaoling, Friedrich, Alexandra, Maier, Jan, Radius, Udo, Santos, Webster L., Marder, Todd B.
Publicado 2020

A Novel Sphingosine Kinase Inhibitor Suppresses Chikungunya Virus Infection

por Oyewole, Opeoluwa O., Dunnavant, Kyle, Bhattarai, Shaurav, Kharel, Yugesh, Lynch, Kevin R., Santos, Webster L., Reid, St. Patrick
Publicado 2022

Discovery of Two Inhibitors of the Type IV Pilus Assembly ATPase PilB as Potential Antivirulence Compounds

por Dye, Keane J., Vogelaar, Nancy J., O’Hara, Megan, Sobrado, Pablo, Santos, Webster, Carlier, Paul R., Yang, Zhaomin
Publicado 2022

The impact of sphingosine kinase inhibitor-loaded nanoparticles on bioelectrical and biomechanical properties of cancer cells

por Babahosseini, Hesam, Srinivasaraghavan, Vaishnavi, Zhao, Zongmin, Gillam, Frank, Childress, Elizabeth, Strobl, Jeannine S., Santos, Webster L., Zhang, Chenming, Agah, Masoud
Publicado 2015

Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues

por Pashikanti, Srinath, Foster, Daniel J., Kharel, Yugesh, Brown, Anne M., Bevan, David R., Lynch, Kevin R., Santos, Webster L.
Publicado 2022

Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke

por Cao, Rui, Li, Jun, Kharel, Yugesh, Zhang, Chenchu, Morris, Emily, Santos, Webster L., Lynch, Kevin R., Zuo, Zhiyi, Hu, Song
Publicado 2018

Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors

por Kharel, Yugesh, Agah, Sayeh, Huang, Tao, Mendelson, Anna J., Eletu, Oluwafunmilayo T., Barkey-Bircann, Peter, Gesualdi, James, Smith, Jeffrey S., Santos, Webster L., Lynch, Kevin R.
Publicado 2018

Extrachromosomal DNA amplicons in antimalarial‐resistant Plasmodium falciparum

por McDaniels, Jennifer M., Huckaby, Adam C., Carter, Sabrina A., Lingeman, Sabrina, Francis, Audrey, Congdon, Molly, Santos, Webster, Rathod, Pradipsinh K., Guler, Jennifer L.
Publicado 2020

Transition Metal‐Free Regio‐ and Stereo‐Selective trans Hydroboration of 1,3‐Diynes: A Phosphine‐Catalyzed Access to (E)‐1‐Boryl‐1,3‐Enynes

por Jos, Swetha, Szwetkowski, Connor, Slebodnick, Carla, Ricker, Robert, Chan, Ka Lok, Chan, Wing Chun, Radius, Udo, Lin, Zhenyang, Marder, Todd B., Santos, Webster L.
Publicado 2022

Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice

por Chen, Sing-Young, Beretta, Martina, Olzomer, Ellen M., Shah, Divya P., Wong, Derek Y.H., Alexopoulos, Stephanie J., Aleksovska, Isabella, Salamoun, Joseph M., Garcia, Christopher J., Cochran, Blake J., Rye, Kerry-Anne, Smith, Greg C., Byrne, Frances L., Morris, Margaret J., Santos, Webster L., Cantley, James, Hoehn, Kyle L.
Publicado 2023

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

por Alexopoulos, Stephanie J., Chen, Sing-Young, Brandon, Amanda E., Salamoun, Joseph M., Byrne, Frances L., Garcia, Christopher J., Beretta, Martina, Olzomer, Ellen M., Shah, Divya P., Philp, Ashleigh M., Hargett, Stefan R., Lawrence, Robert T., Lee, Brendan, Sligar, James, Carrive, Pascal, Tucker, Simon P., Philp, Andrew, Lackner, Carolin, Turner, Nigel, Cooney, Gregory J., Santos, Webster L., Hoehn, Kyle L.
Publicado 2020

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress

por Byrne, Frances L., Olzomer, Ellen M., Marriott, Gabriella R., Quek, Lake-Ee, Katen, Alice, Su, Jacky, Nelson, Marin E., Hart-Smith, Gene, Larance, Mark, Sebesfi, Veronica F., Cuff, Jeff, Martyn, Gabriella E., Childress, Elizabeth, Alexopoulos, Stephanie J., Poon, Ivan K., Faux, Maree C., Burgess, Antony W., Reid, Glen, McCarroll, Joshua A., Santos, Webster L., Quinlan, Kate GR., Turner, Nigel, Fazakerley, Daniel J., Kumar, Naresh, Hoehn, Kyle L.
Publicado 2019