The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1

por Sapkota, Gopal P.
Publicado 2013

The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways

por Herhaus, Lina, Sapkota, Gopal P.
Publicado 2014

The FAM83 family of proteins: from pseudo-PLDs to anchors for CK1 isoforms

por Bozatzi, Polyxeni, Sapkota, Gopal P.
Publicado 2018

Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity

por Fulcher, Luke J., Sapkota, Gopal P.
Publicado 2020

Advances in targeted degradation of endogenous proteins

por Röth, Sascha, Fulcher, Luke J., Sapkota, Gopal P.
Publicado 2019

IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling

por Dunbar, Karen, Macartney, Thomas J, Sapkota, Gopal P
Publicado 2020

Regulation of the transforming growth factor β pathway by reversible ubiquitylation

por Al-Salihi, Mazin A., Herhaus, Lina, Sapkota, Gopal P.
Publicado 2012

USP11 augments TGFβ signalling by deubiquitylating ALK5

por Al-Salihi, Mazin A., Herhaus, Lina, Macartney, Thomas, Sapkota, Gopal P.
Publicado 2012

OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3

por Herhaus, Lina, Al-Salihi, Mazin, Macartney, Thomas, Weidlich, Simone, Sapkota, Gopal P.
Publicado 2013

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9

por Rojas-Fernandez, Alejandro, Herhaus, Lina, Macartney, Thomas, Lachaud, Christophe, Hay, Ronald T., Sapkota, Gopal P.
Publicado 2015

Targeting endogenous proteins for degradation through the affinity-directed protein missile system

por Fulcher, Luke J., Hutchinson, Luke D., Macartney, Thomas J., Turnbull, Craig, Sapkota, Gopal P.
Publicado 2017

An affinity-directed protein missile system for targeted proteolysis

por Fulcher, Luke J., Macartney, Thomas, Bozatzi, Polyxeni, Hornberger, Annika, Rojas-Fernandez, Alejandro, Sapkota, Gopal P.
Publicado 2016

FAM83F regulates canonical Wnt signalling through an interaction with CK1α

por Dunbar, Karen, Jones, Rebecca A, Dingwell, Kevin, Macartney, Thomas J, Smith, James C, Sapkota, Gopal P
Publicado 2020

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling

por Vogt, Janis, Dingwell, Kevin S., Herhaus, Lina, Gourlay, Robert, Macartney, Thomas, Campbell, David, Smith, James C., Sapkota, Gopal P.
Publicado 2014

Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System

por Röth, Sascha, Macartney, Thomas J., Konopacka, Agnieszka, Chan, Kwok-Ho, Zhou, Houjiang, Queisser, Markus A., Sapkota, Gopal P.
Publicado 2020

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses

por Hutchinson, Luke D., Darling, Nicola J., Nicolaou, Stephanos, Gori, Ilaria, Squair, Daniel R., Cohen, Philip, Hill, Caroline S., Sapkota, Gopal P.
Publicado 2020

Brd4‐Brd2 isoform switching coordinates pluripotent exit and Smad2‐dependent lineage specification

por Fernandez‐Alonso, Rosalia, Davidson, Lindsay, Hukelmann, Jens, Zengerle, Michael, Prescott, Alan R, Lamond, Angus, Ciulli, Alessio, Sapkota, Gopal P, Findlay, Greg M
Publicado 2017

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

por Ramachandran, Anassuya, Vizán, Pedro, Das, Debipriya, Chakravarty, Probir, Vogt, Janis, Rogers, Katherine W, Müller, Patrick, Hinck, Andrew P, Sapkota, Gopal P, Hill, Caroline S
Publicado 2018

Characterisation of the biochemical and cellular roles of native and pathogenic amelogenesis imperfecta mutants of FAM83H

por Tachie-Menson, Theresa, Gázquez-Gutiérrez, Ana, Fulcher, Luke J., Macartney, Thomas J., Wood, Nicola T., Varghese, Joby, Gourlay, Robert, Soares, Renata F., Sapkota, Gopal P.
Publicado 2020

Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System

por Simpson, Luke M., Macartney, Thomas J., Nardin, Alice, Fulcher, Luke J., Röth, Sascha, Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Ganley, Ian G., Sapkota, Gopal P.
Publicado 2020