Synthetic lethality in KRas-driven cancer cells created by glutamine deprivation

por Mukhopadhyay, Suman, Saqcena, Mahesh, Foster, David A.
Publicado 2015

Amino Acids and mTOR Mediate Distinct Metabolic Checkpoints in Mammalian G1 Cell Cycle

por Saqcena, Mahesh, Menon, Deepak, Patel, Deven, Mukhopadhyay, Suman, Chow, Victor, Foster, David A.
Publicado 2013

Blocking anaplerotic entry of glutamine to TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs

por Saqcena, Mahesh, Mukhopadhyay, Suman, Hosny, Carol, Alhamed, Arwa, Chatterjee, Amrita, Foster, David A.
Publicado 2014

Cooperative Genomic Lesions in HRAS-Mutant Cancers Predict Resistance to Farnesyltransferase Inhibitors

por Nigam, Aradhya, Krishnamoorthy, Gnana, Chatila, Walid, Berman, Katherine, Saqcena, Mahesh, Walch, Henry, Ho, Alan, Schultz, Nikolaus, Fagin, James, Untch, Brian
Publicado 2023

Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

por Parisi, Federica, Riccardo, Sara, Daniel, Margaret, Saqcena, Mahesh, Kundu, Nandini, Pession, Annalisa, Grifoni, Daniela, Stocker, Hugo, Tabak, Esteban, Bellosta, Paola
Publicado 2011

Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors

por Garcia-Rendueles, Maria E. R., Krishnamoorthy, Gnana, Saqcena, Mahesh, Acuña-Ruiz, Adrian, Revilla, Giovanna, de Stanchina, Elisa, Knauf, Jeffrey A., Lester, Rona, Xu, Bin, Ghossein, Ronald A., Fagin, James A.
Publicado 2022

Co-inhibition of SMAD and MAPK signaling enhances (124)I uptake in BRAF-mutant thyroid cancers

por Luckett, Kathleen A, Cracchiolo, Jennifer R, Krishnamoorthy, Gnana P, Leandro-Garcia, Luis Javier, Nagarajah, James, Saqcena, Mahesh, Lester, Rona, Im, Soo Y, Zhao, Zhen, Lowe, Scott W, de Stanchina, Elisa, Sherman, Eric J, Ho, Alan L, Leach, Steven D, Knauf, Jeffrey A, Fagin, James A
Publicado 2021