Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology

por Tong, Wenyong, Maira, Mario, Gagnon, Martin, Saragovi, H. Uri
Publicado 2015

UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans

por Papaluca, Arturo, Wagner, J. Richard, Saragovi, H. Uri, Ramotar, Dindial
Publicado 2018

Combinatorial Assembly of Small Molecules into Bivalent Antagonists of TrkC or TrkA Receptors

por Brahimi, Fouad, Ko, Eunhwa, Malakhov, Andrey, Burgess, Kevin, Saragovi, H. Uri
Publicado 2014

Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy

por Bartish, Margarita, del Rincón, Sonia V., Rudd, Christopher E., Saragovi, H. Uri
Publicado 2020

Effective chimeric antigen receptor T cells against SARS-CoV-2

por Guo, Xueyang, Kazanova, Alexandra, Thurmond, Stephanie, Saragovi, H. Uri, Rudd, Christopher E.
Publicado 2021

Signaling pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells

por Thomas, Michael S, Zhang, WenRu, Jordan, Paivi M, Saragovi, H Uri, Taglialatela, Giulio
Publicado 2005

In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death

por Galán, Alba, Jmaeff, Sean, Barcelona, Pablo F., Brahimi, Fouad, Sarunic, Marinko V., Saragovi, H. Uri
Publicado 2017

The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy

por Barcelona, Pablo F., Galan, Alba, Nedev, Hinyu, Jian, Yifan, Sarunic, Marinko V., Saragovi, H. Uri
Publicado 2018

Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies

por Xhima, Kristiana, Markham-Coultes, Kelly, Hahn Kofoed, Rikke, Saragovi, H Uri, Hynynen, Kullervo, Aubert, Isabelle
Publicado 2021

BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hear...

por Szobota, Stephanie, Mathur, Pranav D., Siegel, Sairey, Black, KristenAnn, Saragovi, H. Uri, Foster, Alan C.
Publicado 2019

Raft-Dependent Endocytosis of Autocrine Motility Factor/Phosphoglucose Isomerase: A Potential Drug Delivery Route for Tumor Cells

por Kojic, Liliana D., Wiseman, Sam M., Ghaidi, Fariba, Joshi, Bharat, Nedev, Hinyu, Saragovi, H. Uri, Nabi, Ivan R.
Publicado 2008

Pro370Leu MYOC gene mutation in a large Chinese family with juvenile-onset open angle glaucoma: correlation between genotype and phenotype

por Zhuo, Ye-Hong, Wei, Yan-Tao, Bai, Yu-Jing, Duan, Shan, Lin, Ming-Kai, Saragovi, H. Uri, Ge, Jian
Publicado 2008

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation

por Josephy-Hernandez, Sylvia, Pirvulescu, Iulia, Maira, Mario, Aboulkassim, Tahar, Wong, Tak Pan, McKinney, R. Anne, Saragovi, H. Uri
Publicado 2019

p75(NTR) antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa

por Platón-Corchado, María, Barcelona, Pablo F, Jmaeff, Sean, Marchena, Miguel, Hernández-Pinto, Alberto M, Hernández-Sánchez, Catalina, Saragovi, H Uri, de la Rosa, Enrique J
Publicado 2017

A kinase-deficient TrkC receptor isoform activates Arf6–Rac1 signaling through the scaffold protein tamalin

por Esteban, Pedro F., Yoon, Hye-Young, Becker, Jodi, Dorsey, Susan G., Caprari, Paola, Palko, Mary Ellen, Coppola, Vincenzo, Saragovi, H. Uri, Randazzo, Paul A., Tessarollo, Lino
Publicado 2006

Neuronal Injury External to the Retina Rapidly Activates Retinal Glia, Followed by Elevation of Markers for Cell Cycle Re-Entry and Death in Retinal Ganglion Cells

por Galan, Alba, Dergham, Pauline, Escoll, Pedro, de-la-Hera, Antonio, D'Onofrio, Philippe M., Magharious, Mark M., Koeberle, Paulo D., Frade, José María, Saragovi, H. Uri
Publicado 2014

Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands

por Brahimi, Fouad, Galan, Alba, Jmaeff, Sean, Barcelona, Pablo F., De Jay, Nicolas, Dejgaard, Kurt, Young, Jason C., Kleinman, Claudia L., Thomas, David Y., Saragovi, H. Uri
Publicado 2020

The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS

por Brahimi, Fouad, Maira, Mario, Barcelona, Pablo F., Galan, Alba, Aboulkassim, Tahar, Teske, Katrina, Rogers, Mary-Louise, Bertram, Lisa, Wang, Jing, Yousefi, Masoud, Rush, Robert, Fabian, Marc, Cashman, Neil, Saragovi, H. Uri
Publicado 2016

GD2 and GD3 gangliosides as diagnostic biomarkers for all stages and subtypes of epithelial ovarian cancer

por Galan, Alba, Papaluca, Arturo, Nejatie, Ali, Matanes, Emad, Brahimi, Fouad, Tong, Wenyong, Hachim, Ibrahim Yaseen, Yasmeen, Amber, Carmona, Euridice, Klein, Kathleen Oros, Billes, Sonja, Dawod, Ahmed E., Gawande, Prasad, Jeter, Anna Milik, Mes-Masson, Anne-Marie, Greenwood, Celia M. T., Gotlieb, Walter H., Saragovi, H. Uri
Publicado 2023

Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism.

por García-Silva, Susana, Benito-Martín, Alberto, Nogués, Laura, Hernández-Barranco, Alberto, Mazariegos, Marina S., Santos, Vanesa, Hergueta-Redondo, Marta, Ximénez-Embún, Pilar, Kataru, Raghu P., Lopez, Ana Amor, Merino, Cristina, Sánchez-Redondo, Sara, Graña-Castro, Osvaldo, Matei, Irina, Nicolás-Avila, José Ángel, Torres-Ruiz, Raúl, Rodríguez-Perales, Sandra, Martínez, Lola, Pérez-Martínez, Manuel, Mata, Gadea, Szumera-Ciećkiewicz, Anna, Kalinowska, Iwona, Saltari, Annalisa, Martínez-Gómez, Julia M., Hogan, Sabrina A., Saragovi, H. Uri, Ortega, Sagrario, Garcia-Martin, Carmen, Boskovic, Jasminka, Levesque, Mitchell P., Rutkowski, Piotr, Hidalgo, Andrés, Muñoz, Javier, Megías, Diego, Mehrara, Babak J., Lyden, David, Peinado, Héctor
Publicado 2021