Murine Models of Lysosomal Storage Diseases Exhibit Differences in Brain Protein Aggregation and Neuroinflammation

por Clarke, Jennifer, Kayatekin, Can, Viel, Catherine, Shihabuddin, Lamya, Sardi, Sergio Pablo
Publicado 2021

Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies

por Menon, Sindhu, Armstrong, Sabrina, Hamzeh, Amir, Visanji, Naomi P., Sardi, Sergio Pablo, Tandon, Anurag
Publicado 2022

No evidence for substrate accumulation in Parkinson brains with GBA mutations

por Gegg, Matthew E., Sweet, Lindsay, Wang, Bing H., Shihabuddin, Lamya S., Sardi, Sergio Pablo, Schapira, Anthony H.V.
Publicado 2015

Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation

por Bae, Eun-Jin, Yang, Na Young, Lee, Cheolsoon, Lee, He-Jin, Kim, Seokjoong, Sardi, Sergio Pablo, Lee, Seung-Jae
Publicado 2015

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration

por Davis, Marie Y., Trinh, Kien, Thomas, Ruth E., Yu, Selina, Germanos, Alexandre A., Whitley, Brittany N., Sardi, Sergio Pablo, Montine, Thomas J., Pallanck, Leo J.
Publicado 2016

Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations

por Li, Hongyu, Ham, Ahrom, Ma, Thong Chi, Kuo, Sheng-Han, Kanter, Ellen, Kim, Donghoon, Ko, Han Seok, Quan, Yi, Sardi, Sergio Pablo, Li, Aiqun, Arancio, Ottavio, Kang, Un Jung, Sulzer, David, Tang, Guomei
Publicado 2018

Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson’s disease enrolled in PPMI

por Huh, Young Eun, Park, Hyejung, Chiang, Ming Sum Ruby, Tuncali, Idil, Liu, Ganqiang, Locascio, Joseph J., Shirvan, Julia, Hutten, Samantha J., Rotunno, Melissa S., Viel, Catherine, Shihabuddin, Lamya S., Wang, Bing, Sardi, Sergio Pablo, Scherzer, Clemens R.
Publicado 2021

Longitudinal Measurements of Glucocerebrosidase activity in Parkinson’s patients

por Alcalay, Roy N., Wolf, Pavlina, Chiang, Ming Sum Ruby, Helesicova, Karolina, Zhang, Xiaokui Kate, Merchant, Kalpana, Hutten, Samantha J., Scherzer, Clemens, Caspell‐Garcia, Chelsea, Blauwendraat, Cornelis, Foroud, Tatiana, Nudelman, Kelly, Gan‐Or, Ziv, Simuni, Tanya, Chahine, Lana M., Levy, Oren, Zheng, Dandi, Li, Gen, Sardi, Sergio Pablo
Publicado 2020

Safety, Pharmacokinetics, and Pharmacodynamics of Oral Venglustat in Patients with Parkinson’s Disease and a GBA Mutation: Results from Part 1 of the Randomized, Double-Blinded, Pl...

por Peterschmitt, M. Judith, Saiki, Hidemoto, Hatano, Taku, Gasser, Thomas, Isaacson, Stuart H., Gaemers, Sebastiaan J.M., Minini, Pascal, Saubadu, Stéphane, Sharma, Jyoti, Walbillic, Samantha, Alcalay, Roy N., Cutter, Gary, Hattori, Nobutaka, Höglinger, Günter U., Marek, Kenneth, Schapira, Anthony H.V., Scherzer, Clemens R., Simuni, Tanya, Giladi, Nir, Sardi, Sergio Pablo, Fischer, Tanya Z.
Publicado 2022