Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage

por Gutierrez-Martinez, Paula, Hogdal, Leah, Nagai, Manavi, Kruta, Miriama, Singh, Rumani, Sarosiek, Kristopher, Nussenzweig, Andre, Beerman, Isabel, Letai, Anthony, Rossi, Derrick J.
Publicado 2018

Safer-by-design flame-sprayed silicon dioxide nanoparticles: the role of silanol content on ROS generation, surface activity and cytotoxicity

por Rubio, Laura, Pyrgiotakis, Georgios, Beltran-Huarac, Juan, Zhang, Yipei, Gaurav, Joshi, Deloid, Glen, Spyrogianni, Anastasia, Sarosiek, Kristopher A., Bello, Dhimiter, Demokritou, Philip
Publicado 2019

p53 controls choice between apoptotic and non-apoptotic death following DNA damage

por Honeywell, Megan E., Isidor, Marie S., Harper, Nicholas W., Fontana, Rachel E., Cruz-Gordillo, Peter, Porto, Sydney A., Fraser, Cameron S., Sarosiek, Kristopher A., Guertin, David A., Spinelli, Jessica B., Lee, Michael J.
Publicado 2023

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity

por Inde, Zintis, Yapp, Clarence, Joshi, Gaurav N., Spetz, Johan, Fraser, Cameron, Deskin, Brian, Ghelfi, Elisa, Sodhi, Chhinder, Hackam, David J., Kobzik, Lester, Croker, Ben A., Brownfield, Douglas, Jia, Hongpeng, Sarosiek, Kristopher A.
Publicado 2020

Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy–induced toxicities

por Spetz, Johan K. E., Florido, Mary H. C., Fraser, Cameron S., Qin, Xingping, Choiniere, Jonathan, Yu, Stacey J., Singh, Rumani, Friesen, Max, Rubin, Lee L., Salem, Joe-Elie, Moslehi, Javid J., Sarosiek, Kristopher A.
Publicado 2022

Small molecule SJ572946 activates BAK to initiate apoptosis

por Sekar, Giridhar, Singh, Geetika, Qin, Xingping, Guibao, Cristina D., Schwam, Brittany, Inde, Zintis, Grace, Christy R., Zhang, Weixing, Slavish, P. Jake, Lin, Wenwei, Chen, Taosheng, Lee, Richard E., Rankovic, Zoran, Sarosiek, Kristopher, Moldoveanu, Tudor
Publicado 2022

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

por McNamara, Molly C., Hosios, Aaron M., Torrence, Margaret E., Zhao, Ting, Fraser, Cameron, Wilkinson, Meghan, Kwiatkowski, David J., Henske, Elizabeth P., Wu, Chin-Lee, Sarosiek, Kristopher A., Valvezan, Alexander J., Manning, Brendan D.
Publicado 2022

Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics

por Fraser, Cameron S., Spetz, Johan K. E., Qin, Xingping, Presser, Adam, Choiniere, Jonathan, Li, Chendi, Yu, Stacey, Blevins, Frances, Hata, Aaron N., Miller, Jeffrey W., Bradshaw, Gary A., Kalocsay, Marian, Sanchorawala, Vaishali, Sarosiek, Shayna, Sarosiek, Kristopher A.
Publicado 2022

BCL-X(L) directly modulates RAS signalling to favour cancer cell stemness

por Carné Trécesson, Sophie de, Souazé, Frédérique, Basseville, Agnès, Bernard, Anne-Charlotte, Pécot, Jessie, Lopez, Jonathan, Bessou, Margaux, Sarosiek, Kristopher A., Letai, Anthony, Barillé-Nion, Sophie, Valo, Isabelle, Coqueret, Olivier, Guette, Catherine, Campone, Mario, Gautier, Fabien, Juin, Philippe Paul
Publicado 2017

In situ architecture of Opa1-dependent mitochondrial cristae remodeling

por Fry, Michelle Y., Navarro, Paula P., Hakim, Pusparanee, Ananda, Virly Y., Qin, Xingping, Landoni, Juan C., Rath, Sneha, Inde, Zintis, Lugo, Camila Makhlouta, Luce, Bridget E., Ge, Yifan, McDonald, Julie L., Ali, Ilzat, Ha, Leillani L., Kleinstiver, Benjamin P., Chan, David C., Sarosiek, Kristopher A., Chao, Luke H.
Publicado 2023

Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

por Singh, Rumani, Yu, Stacey, Osman, Marwa, Inde, Zintis, Fraser, Cameron, Cleveland, Abigail H., Almanzar, Nicole, Lim, Chuan Bian, Joshi, Gaurav N., Spetz, Johan, Qin, Xingping, Toprani, Sneh M., Nagel, Zachary, Hocking, Matthew C., Cormack, Robert A., Yock, Torunn I., Miller, Jeffrey W., Yuan, Zhi-Min, Gershon, Timothy, Sarosiek, Kristopher A.
Publicado 2023

Tuning ultrasmall theranostic nanoparticles for MRI contrast and radiation dose amplification

por Brown, Needa, Rocchi, Paul, Carmès, Léna, Guthier, Romy, Iyer, Meghna, Seban, Léa, Morris, Toby, Bennett, Stephanie, Lavelle, Michael, Penailillo, Johany, Carrasco, Ruben, Williams, Chris, Huynh, Elizabeth, Han, Zhaohui, Kaza, Evangelia, Doussineau, Tristan, Toprani, Sneh M., Qin, Xingping, Nagel, Zachary D., Sarosiek, Kristopher A., Hagège, Agnès, Dufort, Sandrine, Bort, Guillaume, Lux, François, Tillement, Olivier, Berbeco, Ross
Publicado 2023

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity

por Inde, Zintis, Croker, Ben A., Yapp, Clarence, Joshi, Gaurav N., Spetz, Johan, Fraser, Cameron, Qin, Xingping, Xu, Le, Deskin, Brian, Ghelfi, Elisa, Webb, Gabrielle, Carlin, Aaron F., Zhu, Yanfang Peipei, Leibel, Sandra L., Garretson, Aaron F., Clark, Alex E., Duran, Jason M., Pretorius, Victor, Crotty-Alexander, Laura E., Li, Chendi, Lee, Jamie Casey, Sodhi, Chhinder, Hackam, David J., Sun, Xin, Hata, Aaron N., Kobzik, Lester, Miller, Jeffrey, Park, Jin-Ah, Brownfield, Douglas, Jia, Hongpeng, Sarosiek, Kristopher A.
Publicado 2021

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

por Burger, Jan A., Landau, Dan A., Taylor-Weiner, Amaro, Bozic, Ivana, Zhang, Huidan, Sarosiek, Kristopher, Wang, Lili, Stewart, Chip, Fan, Jean, Hoellenriegel, Julia, Sivina, Mariela, Dubuc, Adrian M., Fraser, Cameron, Han, Yulong, Li, Shuqiang, Livak, Kenneth J., Zou, Lihua, Wan, Youzhong, Konoplev, Sergej, Sougnez, Carrie, Brown, Jennifer R., Abruzzo, Lynne V., Carter, Scott L., Keating, Michael J., Davids, Matthew S., Wierda, William G., Cibulskis, Kristian, Zenz, Thorsten, Werner, Lillian, Cin, Paola Dal, Kharchencko, Peter, Neuberg, Donna, Kantarjian, Hagop, Lander, Eric, Gabriel, Stacey, O'Brien, Susan, Letai, Anthony, Weitz, David A., Nowak, Martin A., Getz, Gad, Wu, Catherine J.
Publicado 2016

Apoptotic cell death in disease—Current understanding of the NCCD 2023

por Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco E., Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K. -M., Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravichandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe S., Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strapazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, Gyorgy, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, Alexei, Villunger, Andreas, von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Huang-Tian, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibing, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, Galluzzi, Lorenzo
Publicado 2023